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Select item 108282691.

In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes

Richard Venz, Anita Goyala, Abel Soto-Gamez, Tugce Yenice, Marco Demaria, Collin Y. Ewald

GeroScience. 2024 Apr; 46(2): 1499–1514. Published online 2023 Aug 29. doi: 10.1007/s11357-023-00909-z

PMCID:: PMC10828269

Abstract Article PDF–3.0M

Select item 106176262.

SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans

Valerie J. Robert, Matthieu Caron, Loic Gely, Annie Adrait, Victoria Pakulska, Yohann Couté, Manon Chevalier, Christian G. Riedel, Cecile Bedet, Francesca Palladino

Development. 2023 Nov 1; 150(21): dev201755. Published online 2023 Oct 17. doi: 10.1242/dev.201755

PMCID:: PMC10617626

Abstract Article

Select item 102957643.

RNA Sequencing of Pooled Samples Effectively Identifies Differentially Expressed Genes

Bokang Ko, Jeremy M. Van Raamsdonk

Biology (Basel) 2023 Jun; 12(6): 812. Published online 2023 Jun 2. doi: 10.3390/biology12060812

PMCID:: PMC10295764

Abstract Article PDF–2.2M

Select item 102562354.

A worm’s life: AMPK links muscle mitochondrial dynamics to physical fitness and healthy aging in Caenorhabditis elegans

Vihang A. Narkar

J Cardiovasc Aging. Author manuscript; available in PMC 2023 Jun 9.

Published in final edited form as: J Cardiovasc Aging. 2023; 3(3): 25. Published online 2023 May 4. doi: 10.20517/jca.2023.14

PMCID:: PMC10256235

Article PDF–237K

Select item 102286505.

Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants

Annika Traa, Hazel Shields, Abdelrahman AlOkda, Zenith D. Rudich, Bokang Ko, Jeremy M. Van Raamsdonk

Front Aging. 2023; 4: 1145198. Published online 2023 May 16. doi: 10.3389/fragi.2023.1145198

PMCID:: PMC10228650

Abstract Article PDF–2.2M

Select item 99262786.

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics

Juliane Cruz Campos, Luiz Henrique Marchesi Bozi, Barbara Krum, Luiz Roberto Grassmann Bechara, Nikolas Dresch Ferreira, Gabriel Santos Arini, Rudá Prestes Albuquerque, Annika Traa, Takafumi Ogawa, Alexander M. van der Bliek, Afshin Beheshti, Edward T. Chouchani, Jeremy M. Van Raamsdonk, T. Keith Blackwell, Julio Cesar Batista Ferreira

Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2): e2204750120. Published online 2023 Jan 3. doi: 10.1073/pnas.2204750120

PMCID:: PMC9926278

Abstract Article PDF–5.4M

Select item 97108737.

Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

Robyn Branicky, Ying Wang, Arman Khaki, Ju-Ling Liu, Maximilian Kramer-Drauberg, Siegfried Hekimi

Sci Adv. 2022 Dec; 8(48): eadc9851. Published online 2022 Nov 30. doi: 10.1126/sciadv.adc9851

PMCID:: PMC9710873

Abstract Article PDF–2.2M

Select item 95481818.

Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents

Alan D. Winter, Elissa Tjahjono, Leonardo J. Beltrán, Iain L. Johnstone, Neil J. Bulleid, Antony P. Page

BMC Biol. 2022; 20: 228. Published online 2022 Oct 8. doi: 10.1186/s12915-022-01415-y

PMCID:: PMC9548181

Abstract Article PDF–2.5M

Select item 94378489.

Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans

Murat Artan, Markus Hartl, Weiqiang Chen, Mario de Bono

J Biol Chem. 2022 Sep; 298(9): 102343. Published online 2022 Aug 3. doi: 10.1016/j.jbc.2022.102343

PMCID:: PMC9437848

Abstract Article PDF–2.0M

Select item 924922310.

ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans

Lina Zhao, Lorenz A. Fenk, Lars Nilsson, Niko Paresh Amin-Wetzel, Nelson Javier Ramirez-Suarez, Mario de Bono, Changchun Chen

PLoS Biol. 2022 Jun; 20(6): e3001684. Published online 2022 Jun 21. doi: 10.1371/journal.pbio.3001684

PMCID:: PMC9249223

Abstract Article PDF–3.5M

Select item 919683011.

MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications

Murat Artan, Jooyeon Sohn, Cheolju Lee, Seung-Yeol Park, Seung-Jae V. Lee

Autophagy. 2022; 18(5): 1208–1210. Published online 2022 Feb 19. doi: 10.1080/15548627.2022.2039523

PMCID:: PMC9196830

Abstract Article PDF–484K

Select item 912695412.

Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants

Namastheé Harris-Gauthier, Annika Traa, Abdelrahman AlOkda, Alibek Moldakozhayev, Ulrich Anglas, Sonja K. Soo, Jeremy M. Van Raamsdonk

Redox Biol. 2022 Jul; 53: 102335. Published online 2022 May 13. doi: 10.1016/j.redox.2022.102335

PMCID:: PMC9126954

Abstract Article PDF–8.9M

Select item 906607413.

CEST‐2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants

Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler‐Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gómez Martín, Fabio Bertan, Chester J J Wrobel, Frank C Schroeder, Dan Ehninger, Kristian Händler, Joachim L Schultze, Lukas Schreiber, Gerhild van Echten‐Deckert, Pierluigi Nicotera, Daniele Bano

EMBO Rep. 2022 May; 23(5): e52606. Published online 2022 Mar 17. doi: 10.15252/embr.202152606

PMCID:: PMC9066074

Abstract Article PDF–4.8M

Select item 896172814.

Mitonuclear Mismatch is Associated With Increased Male Frequency, Outcrossing, and Male Sperm Size in Experimentally-Evolved C. elegans

Brent W. Bever, Zachary P. Dietz, Jennifer A. Sullins, Ariana M. Montoya, Ulfar Bergthorsson, Vaishali Katju, Suzanne Estes

Front Genet. 2022; 13: 742272. Published online 2022 Mar 11. doi: 10.3389/fgene.2022.742272

PMCID:: PMC8961728

Abstract Article PDF–1.2M

Select item 885722615.

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald

Nat Commun. 2022; 13: 967. Published online 2022 Feb 18. doi: 10.1038/s41467-022-28599-9

PMCID:: PMC8857226

Abstract Article PDF–2.5M

Select item 864193116.

MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans

Yoonji Jung, Murat Artan, Nari Kim, Jeonghun Yeom, Ara B. Hwang, Dae-Eun Jeong, Özlem Altintas, Keunhee Seo, Mihwa Seo, Dongyeop Lee, Wooseon Hwang, Yujin Lee, Jooyeon Sohn, Eun Ji E. Kim, Sungeun Ju, Seong Kyu Han, Hyun-Jun Nam, Linnea Adams, Youngjae Ryu, Dong Jin Moon, Chanhee Kang, Joo-Yeon Yoo, Sang Ki Park, Chang Man Ha, Malene Hansen, Sanguk Kim, Cheolju Lee, Seung-Yeol Park, Seung-Jae V. Lee

Sci Adv. 2021 Dec; 7(49): eabj8156. Published online 2021 Dec 3. doi: 10.1126/sciadv.abj8156

PMCID:: PMC8641931

Abstract Article PDF–6.0M

Select item 848782817.

Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age-Related Diseases by Activating AMPK, DAF-16, and HSF-1

Wen-Yu Zeng, Lin Tan, Cong Han, Zhuo-Ya Zheng, Gui-Sheng Wu, Huai-Rong Luo, Su-Lian Li

Oxid Med Cell Longev. 2021; 2021: 7656834. Published online 2021 Sep 25. doi: 10.1155/2021/7656834

PMCID:: PMC8487828

Abstract Article PDF–2.4M

Select item 844679318.

Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling

Murat Artan, Stephen Barratt, Sean M. Flynn, Farida Begum, Mark Skehel, Armel Nicolas, Mario de Bono

J Biol Chem. 2021 Sep; 297(3): 101094. Published online 2021 Aug 18. doi: 10.1016/j.jbc.2021.101094

Correction in:: J Biol Chem. 2022 Jun; 298(6): 102081.

PMCID:: PMC8446793

Abstract Article PDF–1.6M

Select item 842868419.

Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans

Peter A. Kropp, Jing Wu, Michael Reidy, Sanjay Shrestha, Kyle Rhodehouse, Philippa Rogers, Michael N. Sack, Andy Golden

PLoS Genet. 2021 Aug; 17(8): e1009771. Published online 2021 Aug 27. doi: 10.1371/journal.pgen.1009771

PMCID:: PMC8428684

Abstract Article PDF–3.2M

Select item 833118320.

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

Patricia Giselle Cipriani, Olivia Bay, John Zinno, Michelle Gutwein, Hin Hark Gan, Vinay K Mayya, George Chung, Jia-Xuan Chen, Hala Fahs, Yu Guan, Thomas F Duchaine, Matthias Selbach, Fabio Piano, Kristin C Gunsalus

eLife. 2021; 10: e60833. Published online 2021 Jul 5. doi: 10.7554/eLife.60833

PMCID:: PMC8331183

Abstract Article PDF–8.5M

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