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Select item 114641271.

Age‐dependent heat shock hormesis to HSF‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans

Dániel Kovács, János Barnabás Biró, Saqib Ahmed, Márton Kovács, Tímea Sigmond, Bernadette Hotzi, Máté Varga, Viktor Vázsony Vincze, Umar Mohammad, Tibor Vellai, János Barna

Aging Cell. 2024 Oct; 23(10): e14246. Published online 2024 Jun 19. doi: 10.1111/acel.14246

PMCID:: PMC11464127

Abstract Article PDF–1.9M

Select item 114058932.

Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy

Tripti Nair, Brandy A. Weathers, Nicole L. Stuhr, James D. Nhan, Sean P. Curran

Nat Commun. 2024; 15: 8129. Published online 2024 Sep 16. doi: 10.1038/s41467-024-52233-5

PMCID:: PMC11405893

Abstract Article PDF–3.1M

Select item 111269373.

Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation

Weisha Li, Rebecca L. McIntyre, Bauke V. Schomakers, Rashmi Kamble, Anne H.G. Luesink, Michel van Weeghel, Riekelt H. Houtkooper, Arwen W. Gao, Georges E. Janssens

iScience. 2024 Jun 21; 27(6): 109949. Published online 2024 May 8. doi: 10.1016/j.isci.2024.109949

PMCID:: PMC11126937

Abstract Article PDF–4.4M

Select item 111177594.

Sulforaphane Exposure Prevents Cadmium-Induced Toxicity and Mitochondrial Dysfunction in the Nematode Caenorhabditis elegans by Regulating the Insulin/Insulin-like Growth Factor Signaling (IIS) Pathway

Estefani Yaquelin Hernández-Cruz, Omar Emiliano Aparicio-Trejo, Dianelena Eugenio-Pérez, Elí Juárez-Peredo, Mariana Zurita-León, Víctor Julián Valdés, José Pedraza-Chaverri

Antioxidants (Basel) 2024 May; 13(5): 584. Published online 2024 May 9. doi: 10.3390/antiox13050584

PMCID:: PMC11117759

Abstract Article PDF–5.2M

Select item 110043425.

Phloretic acid requires the insulin/IGF-1 pathway and autophagy to enhance stress resistance and extend the lifespan of Caenorhabditis elegans

Bo Li, Li Dong, Wei Meng, Shi-Ying Xiong, Gui-Sheng Wu, Wen-Zhe Ma, Huai-Rong Luo

Front Pharmacol. 2024; 15: 1384227. Published online 2024 Mar 27. doi: 10.3389/fphar.2024.1384227

PMCID:: PMC11004342

Abstract Article PDF–3.0M

Select item 110039586.

An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress

Carlos A. Vergani-Junior, Raíssa De P. Moro, Silas Pinto, Evandro A. De-Souza, Henrique Camara, Deisi L. Braga, Guilherme Tonon-da-Silva, Thiago L. Knittel, Gabriel P. Ruiz, Raissa G. Ludwig, Katlin B. Massirer, William B. Mair, Marcelo A. Mori

Nat Commun. 2024; 15: 3070. Published online 2024 Apr 9. doi: 10.1038/s41467-024-47306-4

PMCID:: PMC11003958

Abstract Article PDF–1.9M

Select item 109593737.

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

Dingxia Feng, Long Qu, Jo Anne Powell-Coffman

PLoS One. 2024; 19(3): e0295093. Published online 2024 Mar 22. doi: 10.1371/journal.pone.0295093

PMCID:: PMC10959373

Abstract Article PDF–1.0M

Select item 109570888.

Proteasome inhibition triggers tissue-specific immune responses against different pathogens in C. elegans

Manish Grover, Spencer S. Gang, Emily R. Troemel, Michalis Barkoulas

PLoS Biol. 2024 Mar; 22(3): e3002543. Published online 2024 Mar 11. doi: 10.1371/journal.pbio.3002543

PMCID:: PMC10957088

Abstract Article PDF–2.9M

Select item 109449329.

Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes

Chris D. Turner, Carmen M. Ramos, Sean P. Curran

Front Aging. 2024; 5: 1369740. Published online 2024 Mar 4. doi: 10.3389/fragi.2024.1369740

PMCID:: PMC10944932

Abstract Article PDF–1.4M

Select item 1092858110.

SKN‐1/NRF2 upregulation by vitamin A is conserved from nematodes to mammals and is critical for lifespan extension in Caenorhabditis elegans

Chaweewan Sirakawin, Dongfa Lin, Ziyue Zhou, Xiaoxin Wang, Rhianne Kelleher, Shangyuan Huang, Weimiao Long, Andre Pires‐daSilva, Yu Liu, Jingjing Wang, Ilya A. Vinnikov

Aging Cell. 2024 Mar; 23(3): e14064. Published online 2023 Dec 15. doi: 10.1111/acel.14064

PMCID:: PMC10928581

Abstract Article PDF–4.5M

Select item 1088623111.

Butein Increases Resistance to Oxidative Stress and Lifespan with Positive Effects on the Risk of Age-Related Diseases in Caenorhabditis elegans

Seona Kim, Hyemin Yoon, Sang-Kyu Park

Antioxidants (Basel) 2024 Feb; 13(2): 155. Published online 2024 Jan 26. doi: 10.3390/antiox13020155

PMCID:: PMC10886231

Abstract Article PDF–3.0M

Select item 1086927712.

SKN-1 is indispensable for protection against Aβ-induced proteotoxicity by a selenopeptide derived from Cordyceps militaris

Mengfei Chen, Zhenjun Zhu, Shujian Wu, Aohuan Huang, Zhiqing Xie, Jie Cai, Rong Huang, Shubo Yu, Ming Liu, Jumei Zhang, Yuchung Tse, Qingping Wu, Juan Wang, Yu Ding

Redox Biol. 2024 Apr; 70: 103065. Published online 2024 Feb 5. doi: 10.1016/j.redox.2024.103065

PMCID:: PMC10869277

Abstract Article PDF–4.2M

Select item 1086120713.

Abalone peptide increases stress resilience and cost‐free longevity via SKN‐1‐governed transcriptional metabolic reprogramming in C. elegans

Qiangqiang Wang, Liangyi Wang, Ziliang Huang, Yue Xiao, Mao Liu, Huihui Liu, Yi Yu, Ming Liang, Ning Luo, Kunping Li, Ajay Mishra, Zebo Huang

Aging Cell. 2024 Feb; 23(2): e14046. Published online 2023 Nov 22. doi: 10.1111/acel.14046

PMCID:: PMC10861207

Abstract Article PDF–7.2M

Select item 1085048814.

Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance

Jing Yu, Xiaoyan Gao, Lijun Zhang, Hang Shi, Yingxuan Yan, Yongli Han, Chengyuan Wu, Ying Liu, Minglv Fang, Cheng Huang, Shengjie Fan

Sci Rep. 2024; 14: 3158. Published online 2024 Feb 7. doi: 10.1038/s41598-024-53374-9

PMCID:: PMC10850488

Abstract Article PDF–6.3M

Select item 1075630315.

Chris D. Turner, Nicole L. Stuhr, Carmen M. Ramos, Bennett T. Van Camp, Sean P. Curran

Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52): e2308565120. Published online 2023 Dec 19. doi: 10.1073/pnas.2308565120

PMCID:: PMC10756303

Abstract Article PDF–2.2M

Select item 1072161316.

On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging

Hope Dang, Raul Castro-Portuguez, Luis Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Emily A. Gardea, Leah M. Chang, Jonah Balsa, Niall Thorns, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, George L. Sutphin

Nat Commun. 2023; 14: 8338. Published online 2023 Dec 14. doi: 10.1038/s41467-023-43527-1

PMCID:: PMC10721613

Abstract Article PDF–1.2M

Select item 1065642617.

Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development

Chee Kiang Ewe, Erica M. Sommermann, Josh Kenchel, Sagen E. Flowers, Morris F. Maduro, Pradeep M. Joshi, Joel H. Rothman

Development. 2022 Jun 15; 149(12): dev200337. Published online 2022 Jun 27. doi: 10.1242/dev.200337

PMCID:: PMC10656426

Abstract Article

Select item 1064374218.

Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation

Carmen M. Ramos, Sean P. Curran

GeroScience. 2023 Dec; 45(6): 3359–3370. Published online 2023 Sep 26. doi: 10.1007/s11357-023-00937-9

PMCID:: PMC10643742

Abstract Article PDF–4.0M

Select item 1061019919.

Improvement of Locomotion Caused by Lactococcus lactis subsp. lactis in the Model Organism Caenorhabditis elegans

Mohammad Shaokat Ali, Shamima Ahmed, Shino Takeuchi, Takayuki Wada, Eriko Kage-Nakadai

Nutrients. 2023 Oct; 15(20): 4482. Published online 2023 Oct 23. doi: 10.3390/nu15204482

PMCID:: PMC10610199

Abstract Article PDF–3.9M

Select item 1055091720.

Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans

Kishoree K. Kumaree, Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Tewin Tencomnao, Chaiyavat Chaiyasut, Anchalee Prasansuklab

Sci Rep. 2023; 13: 16707. Published online 2023 Oct 4. doi: 10.1038/s41598-023-43846-9