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Select item 107978061.

A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan

Manish Chamoli, Anand Rane, Anna Foulger, Shankar J. Chinta, Azar Asadi Shahmirzadi, Caroline Kumsta, Dhanya K. Nambiar, David Hall, Angelina Holcom, Suzanne Angeli, Minna Schmidt, Sharon Pitteri, Malene Hansen, Gordon J. Lithgow, Julie K. Andersen

Nat Aging. Author manuscript; available in PMC 2024 Jan 19.

Published in final edited form as: Nat Aging. 2023 Dec; 3(12): 1529–1543. Published online 2023 Nov 13. doi: 10.1038/s43587-023-00524-9

PMCID:: PMC10797806

Abstract Article PDF–3.4M

Select item 104574632.

CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans

Wan-Xin Zeng, Haowen Liu, Yue Hao, Kang-Ying Qian, Fu-Min Tian, Lei Li, Bin Yu, Xian-Ting Zeng, Shangbang Gao, Zhitao Hu, Xia-Jing Tong

J Cell Biol. 2023 Nov 6; 222(11): e202301117. Published online 2023 Aug 25. doi: 10.1083/jcb.202301117

PMCID:: PMC10457463

Abstract Article PDF–6.8M

Select item 104545693.

Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans

Ban-seok Kim, Alfredo V. Alcantara, Jr., Je-Hyun Moon, Atsushi Higashitani, Nahoko Higashitani, Timothy Etheridge, Nathaniel J. Szewczyk, Colleen S. Deane, Christopher J. Gaffney, Akira Higashibata, Toko Hashizume, Kyoung-hye Yoon, Jin I. Lee

Int J Mol Sci. 2023 Aug; 24(16): 12640. Published online 2023 Aug 10. doi: 10.3390/ijms241612640

PMCID:: PMC10454569

Abstract Article PDF–3.0M

Select item 103932964.

Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans

Rebeca Brocal-Ruiz, Ainara Esteve-Serrano, Carlos Mora-Martínez, Maria Luisa Franco-Rivadeneira, Peter Swoboda, Juan J Tena, Marçal Vilar, Nuria Flames

eLife. 2023; 12: e89702. Published online 2023 Jul 14. doi: 10.7554/eLife.89702

PMCID:: PMC10393296

Abstract Article PDF–10M

Select item 103536075.

Lycium barbarum glycopetide prolong lifespan and alleviate Parkinson’s disease in Caenorhabditis elegans

Jingming Zheng, Zhenhuan Luo, Kin Chiu, Yimin Li, Jing Yang, Qinghua Zhou, Kwok-Fai So, Qin-Li Wan

Front Aging Neurosci. 2023; 15: 1156265. Published online 2023 Jul 4. doi: 10.3389/fnagi.2023.1156265

PMCID:: PMC10353607

Abstract Article PDF–3.2M

Select item 103450906.

Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans

Fan Xu, Ruoyao Li, Erika D. von Gromoff, Friedel Drepper, Bettina Knapp, Bettina Warscheid, Ralf Baumeister, Wenjing Qi

Nat Commun. 2023; 14: 4176. Published online 2023 Jul 13. doi: 10.1038/s41467-023-39882-8

PMCID:: PMC10345090

Abstract Article PDF–8.1M

Select item 103130527.

Filarial DAF-12 sense the host serum to resume iL3 development during infection

Rémy Bétous, Anthony Emile, Hua Che, Eva Guchen, Didier Concordet, Thavy Long, Sandra Noack, Paul M. Selzer, Roger Prichard, Anne Lespine

PLoS Pathog. 2023 Jun; 19(6): e1011462. Published online 2023 Jun 20. doi: 10.1371/journal.ppat.1011462

PMCID:: PMC10313052

Abstract Article PDF–2.1M

Select item 102503858.

Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions

Shengjie Fan, Yingxuan Yan, Ying Xia, Zhenyu Zhou, Lingling Luo, Mengnan Zhu, Yongli Han, Deqiang Yao, Lijun Zhang, Minglv Fang, Lina Peng, Jing Yu, Ying Liu, Xiaoyan Gao, Huida Guan, Hongli Li, Changhong Wang, Xiaojun Wu, Huanhu Zhu, Yu Cao, Cheng Huang

Nat Commun. 2023; 14: 3368. Published online 2023 Jun 8. doi: 10.1038/s41467-023-39118-9

PMCID:: PMC10250385

Abstract Article PDF–3.8M

Select item 102402039.

Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans

Ana P Gómez‐Escribano, Carlos Mora‐Martínez, Marta Roca, Denise S Walker, Joaquín Panadero, Maria D Sequedo, Ratni Saini, Hans‐Joachim Knölker, Jose Blanca, Juan Burguera, Agustin Lahoz, Joaquin Cañizares, José M Millán, Nick O Burton, William R Schafer, Rafael P Vázquez‐Manrique

EMBO Rep. 2023 Jun; 24(6): e55556. Published online 2023 Apr 27. doi: 10.15252/embr.202255556

PMCID:: PMC10240203

Abstract Article PDF–1.5M

Select item 988544010.

Intracellular lipid surveillance by small G protein geranylgeranylation

Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald, Peter M. Douglas

Nature. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Nature. 2022 May; 605(7911): 736–740. Published online 2022 May 18. doi: 10.1038/s41586-022-04729-7

PMCID:: PMC9885440

Abstract Article PDF–4.2M

Select item 987915011.

Dauer fate in a Caenorhabditis elegans Boolean network model

Alekhya Kandoor, Janna Fierst

PeerJ. 2023; 11: e14713. Published online 2023 Jan 23. doi: 10.7717/peerj.14713

PMCID:: PMC9879150

Abstract Article PDF–791K

Select item 934884812.

Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B

Chad Steven Cockrum, Susan Strome

eLife. 2022; 11: e77951. Published online 2022 Aug 3. doi: 10.7554/eLife.77951

PMCID:: PMC9348848

Abstract Article PDF–2.7M

Select item 923309313.

A cilia-independent function of BBSome mediated by DLK MAPK signaling in C. elegans photosensation

Xinxing Zhang, Jinzhi Liu, Tong Pan, Alex Ward, Jianfeng Liu, X.Z. Shawn Xu

Dev Cell. Author manuscript; available in PMC 2023 Jun 20.

Published in final edited form as: Dev Cell. 2022 Jun 20; 57(12): 1545–1557.e4. Published online 2022 May 31. doi: 10.1016/j.devcel.2022.05.005

PMCID:: PMC9233093

Abstract Article PDF–1.1M

Select item 916964614.

The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans

Diego M. Jofré, Dane K. Hoffman, Ailen S. Cervino, Gabriella M. Hahn, McKenzie Grundy, Sijung Yun, Francis R. G. Amrit, Donna B. Stolz, Luciana F. Godoy, Esteban Salvatore, Fabiana A. Rossi, Arjumand Ghazi, M. Cecilia Cirio, Judith L. Yanowitz, Daniel Hochbaum

Proc Natl Acad Sci U S A. 2022 Apr 12; 119(15): e2109508119. Published online 2022 Apr 8. doi: 10.1073/pnas.2109508119

PMCID:: PMC9169646

Abstract Article PDF–2.0M

Select item 914857115.

Both entry to and exit from diapause arrest in Caenorhabditis elegans are regulated by a steroid hormone pathway

Mark G. Zhang, Paul W. Sternberg

Development. 2022 May 1; 149(9): dev200173. Published online 2022 May 3. doi: 10.1242/dev.200173

PMCID:: PMC9148571

Abstract Article

Select item 875312216.

Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes

Manusnan Suriyalaksh, Celia Raimondi, Abraham Mains, Anne Segonds-Pichon, Shahzabe Mukhtar, Sharlene Murdoch, Rebeca Aldunate, Felix Krueger, Roger Guimerà, Simon Andrews, Marta Sales-Pardo, Olivia Casanueva

iScience. 2022 Jan 21; 25(1): 103663. Published online 2021 Dec 20. doi: 10.1016/j.isci.2021.103663

PMCID:: PMC8753122

Abstract Article PDF–4.6M

Select item 873347717.

Neuronal KGB-1 JNK MAPK signaling regulates the dauer developmental decision in response to environmental stress in Caenorhabditis elegans

Deepshikha Dogra, Warakorn Kulalert, Frank C Schroeder, Dennis H Kim

Genetics. 2022 Jan; 220(1): iyab186. Published online 2021 Nov 2. doi: 10.1093/genetics/iyab186

PMCID:: PMC8733477

Abstract Article PDF–1.2M

Select item 865128718.

Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

Zhu Wang, Mi Cheong Cheong, Jet Tsien, Heping Deng, Tian Qin, Jonathan DC Stoltzfus, Tegegn G Jaleta, Xinshe Li, James B Lok, Steven A Kliewer, David J Mangelsdorf

eLife. 2021; 10: e73535. Published online 2021 Dec 7. doi: 10.7554/eLife.73535