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Select item 112161681.

Nuclear receptor signaling via NHR-49/MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues

Ambre J. Sala, Rogan A. Grant, Ghania Imran, Claire Morton, Renee M. Brielmann, Szymon Gorgoń, Jennifer Watts, Laura C. Bott, Richard I. Morimoto

Genes Dev. 2024 May 1; 38(9-10): 380–392. doi: 10.1101/gad.351829.124

PMCID:: PMC11216168

Abstract Article PDF–4.5M

Select item 103207662.

A transcriptional cofactor regulatory network for the C. elegans intestine

Brent B Horowitz, Shivani Nanda, Albertha J M Walhout

G3 (Bethesda) 2023 Jul; 13(7): jkad096. Published online 2023 Apr 29. doi: 10.1093/g3journal/jkad096

PMCID:: PMC10320766

Abstract Article PDF–1.9M

Select item 102343983.

Mediator subunit MDT-15 promotes expression of propionic acid breakdown genes to prevent embryonic lethality in Caenorhabditis elegans

Grace Ying Shyen Goh, Arshia Beigi, Junran Yan, Kelsie R S Doering, Stefan Taubert

G3 (Bethesda) 2023 Jun; 13(6): jkad087. Published online 2023 Apr 19. doi: 10.1093/g3journal/jkad087

PMCID:: PMC10234398

Abstract Article PDF–639K

Select item 101918614.

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

Hyun Ju Lee, Hafiza Alirzayeva, Seda Koyuncu, Amirabbas Rueber, Alireza Noormohammadi, David Vilchez

Nat Aging. 2023; 3(5): 546–566. Published online 2023 Apr 3. doi: 10.1038/s43587-023-00383-4

PMCID:: PMC10191861

Abstract Article PDF–9.4M

Select item 98941175.

The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways

Kai Mao, Peter Breen, Gary Ruvkun

Proc Natl Acad Sci U S A. 2022 Dec 6; 119(49): e2215966119. Published online 2022 Nov 29. doi: 10.1073/pnas.2215966119

PMCID:: PMC9894117

Abstract Article PDF–3.5M

Select item 98494026.

A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity

Jin-Hyuck Jeong, Jun-Seok Han, Youngae Jung, Seung-Min Lee, So-Hyun Park, Mooncheol Park, Min-Gi Shin, Nami Kim, Mi Sun Kang, Seokho Kim, Kwang-Pyo Lee, Ki-Sun Kwon, Chun-A. Kim, Yong Ryoul Yang, Geum-Sook Hwang, Eun-Soo Kwon

Nat Commun. 2023; 14: 288. Published online 2023 Jan 18. doi: 10.1038/s41467-023-35952-z

PMCID:: PMC9849402

Abstract Article PDF–2.5M

Select item 96497477.

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Changnan Wang, Bingying Wang, Taruna Pandey, Yong Long, Jianxiu Zhang, Fiona Oh, Jessica Sima, Ruyin Guo, Yun Liu, Chao Zhang, Shaeri Mukherjee, Michael Bassik, Weichun Lin, Huichao Deng, Goncalo Vale, Jeffrey G. McDonald, Kang Shen, Dengke K. Ma

Nat Commun. 2022; 13: 6805. Published online 2022 Nov 10. doi: 10.1038/s41467-022-34450-y

PMCID:: PMC9649747

Abstract Article PDF–3.6M

Select item 95556158.

Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity

Marcos A. Perez, Andrea J. Clostio, Isabel R. Houston, Jimena Ruiz, Leslie Magtanong, Scott J. Dixon, Jennifer L. Watts

PLoS Genet. 2022 Sep; 18(9): e1010436. Published online 2022 Sep 30. doi: 10.1371/journal.pgen.1010436

PMCID:: PMC9555615

Abstract Article PDF–2.9M

Select item 93359409.

A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological traits

Ranjan Devkota, Delaney Kaper, Rakesh Bodhicharla, Marcus Henricsson, Jan Borén, Marc Pilon

Genetics. 2021 Sep; 219(1): iyab093. Published online 2021 Jun 14. doi: 10.1093/genetics/iyab093

PMCID:: PMC9335940

Abstract Article PDF–1.6M

Select item 924087010.

SKN-1 regulates stress resistance downstream of amino catabolism pathways

Phillip A. Frankino, Talha F. Siddiqi, Theodore Bolas, Raz Bar-Ziv, Holly K. Gildea, Hanlin Zhang, Ryo Higuchi-Sanabria, Andrew Dillin

iScience. 2022 Jul 15; 25(7): 104571. Published online 2022 Jun 9. doi: 10.1016/j.isci.2022.104571

PMCID:: PMC9240870

Abstract Article PDF–3.8M

Select item 912776911.

Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions

Alejandra Zárate-Potes, Irtiqa Ali, Margarida Ribeiro Camacho, Hayley Brownless, Alexandre Benedetto

Front Microbiol. 2022; 13: 853629. Published online 2022 May 10. doi: 10.3389/fmicb.2022.853629

PMCID:: PMC9127769

Abstract Article PDF–4.6M

Select item 843352312.

Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling

Jason F. Cooper, Ryan J. Guasp, Meghan Lee Arnold, Barth D. Grant, Monica Driscoll

Proc Natl Acad Sci U S A. 2021 Sep 7; 118(36): e2101410118. Published online 2021 Sep 2. doi: 10.1073/pnas.2101410118

PMCID:: PMC8433523

Abstract Article PDF–1.4M

Select item 833118313.

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

Patricia Giselle Cipriani, Olivia Bay, John Zinno, Michelle Gutwein, Hin Hark Gan, Vinay K Mayya, George Chung, Jia-Xuan Chen, Hala Fahs, Yu Guan, Thomas F Duchaine, Matthias Selbach, Fabio Piano, Kristin C Gunsalus

eLife. 2021; 10: e60833. Published online 2021 Jul 5. doi: 10.7554/eLife.60833

PMCID:: PMC8331183

Abstract Article PDF–8.5M

Select item 808803714.

Paradigm shift: the primary function of the “Adiponectin Receptors” is to regulate cell membrane composition

Marc Pilon

Lipids Health Dis. 2021; 20: 43. Published online 2021 Apr 30. doi: 10.1186/s12944-021-01468-y

PMCID:: PMC8088037

Abstract Article PDF–779K

Select item 799517615.

EPIC: Software Toolkit for Elution Profile-Based Inference of Protein Complexes

Lucas ZhongMing Hu, Florian Goebels, June H. Tan, Eric Wolf, Uros Kuzmanov, Cuihong Wan, Sadhna Phanse, Changjiang Xu, Mike Schertzberg, Andrew G. Fraser, Gary D. Bader, Andrew Emili

Nat Methods. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: Nat Methods. 2019 Aug; 16(8): 737–742. Published online 2019 Jul 15. doi: 10.1038/s41592-019-0461-4

PMCID:: PMC7995176

Abstract Article PDF–1.0M

Select item 784559416.

Novel Immune Modulators Enhance Caenorhabditis elegans Resistance to Multiple Pathogens

Nicholas A. Hummell, Alexey V. Revtovich, Natalia V. Kirienko

mSphere. 2021 Jan-Feb; 6(1): e00950-20. Published online 2021 Jan 6. doi: 10.1128/mSphere.00950-20

PMCID:: PMC7845594

Abstract Article PDF–2.5M

Select item 764291717.

Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans

Richard Venz, Anastasiia Korosteleva, Elisabeth Jongsma, Collin Y. Ewald

G3 (Bethesda) 2020 Nov; 10(11): 3921–3928. Published online 2020 Sep 21. doi: 10.1534/g3.120.401635

PMCID:: PMC7642917

Abstract Article PDF–1.4M

Select item 742828818.

Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins

Kiran Busayavalasa, Mario Ruiz, Ranjan Devkota, Marcus Ståhlman, Rakesh Bodhicharla, Emma Svensk, Nils-Olov Hermansson, Jan Borén, Marc Pilon

PLoS Genet. 2020 Aug; 16(8): e1008975. Published online 2020 Aug 4. doi: 10.1371/journal.pgen.1008975

PMCID:: PMC7428288

Abstract Article PDF–3.9M

Select item 692246419.

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

Naomi Shomer, Alexandre Zacharie Kadhim, Jennifer Margaret Grants, Xuanjin Cheng, Deema Alhusari, Forum Bhanshali, Amy Fong-Yuk Poon, Michelle Ying Ya Lee, Anik Muhuri, Jung In Park, James Shih, Dongyeop Lee, Seung-Jae V. Lee, Francis Christopher Lynn, Stefan Taubert

PLoS Genet. 2019 Dec; 15(12): e1008508. Published online 2019 Dec 9. doi: 10.1371/journal.pgen.1008508