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Select item 108344291.

HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1

Shihui Chen, Carolyn M. Phillips

Nat Commun. 2024; 15: 957. Published online 2024 Feb 1. doi: 10.1038/s41467-024-45245-8

PMCID:: PMC10834429

Abstract Article PDF–5.2M

Select item 106917502.

Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing

Jordan S Brown, Donglei Zhang, Olivia Gaylord, Wenjun Chen, Heng-Chi Lee

Genetics. 2023 Aug; 224(4): iyad095. Published online 2023 May 20. doi: 10.1093/genetics/iyad095

PMCID:: PMC10691750

Abstract Article PDF–2.4M

Select item 104431843.

The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing

Yue-He Ding, Humberto J. Ochoa, Takao Ishidate, Masaki Shirayama, Craig C. Mello

Cell Rep. Author manuscript; available in PMC 2023 Aug 22.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112408. Published online 2023 Apr 20. doi: 10.1016/j.celrep.2023.112408

PMCID:: PMC10443184

Abstract Article PDF–2.6M

Select item 104151814.

An intestinal sphingolipid confers intergenerational neuroprotection

Wenyue Wang, Tessa Sherry, Xinran Cheng, Qi Fan, Rebecca Cornell, Jie Liu, Zhicheng Xiao, Roger Pocock

Nat Cell Biol. 2023; 25(8): 1196–1207. Published online 2023 Aug 3. doi: 10.1038/s41556-023-01195-9

PMCID:: PMC10415181

Abstract Article PDF–4.4M

Select item 102273755.

Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson’s disease

Anthony L. Gaeta, Karolina Willicott, Corey W. Willicott, Luke E. McKay, Candice M. Keogh, Tyler J. Altman, Logan C. Kimble, Abigail L. Yarbrough, Kim A. Caldwell, Guy A. Caldwell

iScience. 2023 Jun 16; 26(6): 106859. Published online 2023 May 12. doi: 10.1016/j.isci.2023.106859

PMCID:: PMC10227375

Abstract Article PDF–3.6M

Select item 101016896.

A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions

Uri Seroussi, Andrew Lugowski, Lina Wadi, Robert X Lao, Alexandra R Willis, Winnie Zhao, Adam E Sundby, Amanda G Charlesworth, Aaron W Reinke, Julie M Claycomb

eLife. 2023; 12: e83853. Published online 2023 Feb 15. doi: 10.7554/eLife.83853

PMCID:: PMC10101689

Abstract Article PDF–4.9M

Select item 100925517.

Multigenerational downregulation of insulin/IGF‐1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing

Elizabeth M. L. Duxbury, Hanne Carlsson, Kris Sales, Zahida Sultanova, Simone Immler, Tracey Chapman, Alexei A. Maklakov

Evolution. 2022 Dec; 76(12): 2829–2845. Published online 2022 Oct 13. doi: 10.1111/evo.14640

PMCID:: PMC10092551

Abstract Article PDF–2.0M

Select item 99506608.

Peroxiredoxin 2 is required for the redox mediated adaptation to exercise

Qin Xia, Jose C. Casas-Martinez, Eduardo Zarzuela, Javier Muñoz, Antonio Miranda-Vizuete, Katarzyna Goljanek-Whysall, Brian McDonagh

Redox Biol. 2023 Apr; 60: 102631. Published online 2023 Feb 9. doi: 10.1016/j.redox.2023.102631

PMCID:: PMC9950660

Abstract Article PDF–15M

Select item 98471399.

Hypoxia induces transgenerational epigenetic inheritance of small RNAs

Simon Yuan Wang, Kathleen Kim, Zach Klapholz O’Brown, Aileen Levan, Anne Elizabeth Dodson, Scott G. Kennedy, Chaim Chernoff, Eric Lieberman Greer

Cell Rep. Author manuscript; available in PMC 2023 Jan 18.

Published in final edited form as: Cell Rep. 2022 Dec 13; 41(11): 111800. doi: 10.1016/j.celrep.2022.111800

PMCID:: PMC9847139

Abstract Article PDF–2.4M

Select item 979847210.

Reprogramming the piRNA pathway for multiplexed and transgenerational gene silencing in C. elegans

Monika Priyadarshini, Julie Zhouli Ni, Amhed M. Vargas-Velazquez, Sam Guoping Gu, Christian Frøkjær-Jensen

Nat Methods. Author manuscript; available in PMC 2022 Dec 29.

Published in final edited form as: Nat Methods. 2022 Feb; 19(2): 187–194. Published online 2022 Feb 3. doi: 10.1038/s41592-021-01369-z

PMCID:: PMC9798472

Abstract Article PDF–4.2M

Select item 946314311.

GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

Wenjun Chen, Jordan S. Brown, Tao He, Wei-Sheng Wu, Shikui Tu, Zhiping Weng, Donglei Zhang, Heng-Chi Lee

Nat Commun. 2022; 13: 5306. Published online 2022 Sep 9. doi: 10.1038/s41467-022-32880-2

PMCID:: PMC9463143

Abstract Article PDF–3.8M

Select item 927652812.

The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates

John Paul Tsu Ouyang, Wenyan Lucy Zhang, Geraldine Seydoux

Nat Cell Biol. 2022; 24(7): 1129–1140. Published online 2022 Jun 23. doi: 10.1038/s41556-022-00940-w

PMCID:: PMC9276528

Abstract Article PDF–8.9M

Select item 907152813.

Dual roles for nuclear RNAi Argonautes in Caenorhabditis elegans dosage compensation

Michael B Davis, Eshna Jash, Bahaar Chawla, Rebecca A Haines, Lillian E Tushman, Ryan Troll, Györgyi Csankovszki

Genetics. 2022 May; 221(1): iyac033. Published online 2022 Mar 2. doi: 10.1093/genetics/iyac033

PMCID:: PMC9071528

Abstract Article PDF–1.3M

Select item 882664614.

Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans

Itai Antoine Toker, Itamar Lev, Yael Mor, Yael Gurevich, Doron Fisher, Leah Houri-Zeevi, Olga Antonova, Hila Doron, Sarit Anava, Hila Gingold, Lilach Hadany, Shai Shaham, Oded Rechavi

Dev Cell. 2022 Feb 7; 57(3): 298–309.e9. doi: 10.1016/j.devcel.2022.01.005

PMCID:: PMC8826646

Abstract Article

Select item 799517615.

EPIC: Software Toolkit for Elution Profile-Based Inference of Protein Complexes

Lucas ZhongMing Hu, Florian Goebels, June H. Tan, Eric Wolf, Uros Kuzmanov, Cuihong Wan, Sadhna Phanse, Changjiang Xu, Mike Schertzberg, Andrew G. Fraser, Gary D. Bader, Andrew Emili

Nat Methods. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: Nat Methods. 2019 Aug; 16(8): 737–742. Published online 2019 Jul 15. doi: 10.1038/s41592-019-0461-4

PMCID:: PMC7995176

Abstract Article PDF–1.0M

Select item 788685316.

Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans

Emiko Okabe, Masaharu Uno, Saya Kishimoto, Eisuke Nishida

Commun Biol. 2021; 4: 207. Published online 2021 Feb 16. doi: 10.1038/s42003-021-01692-3

PMCID:: PMC7886853

Abstract Article PDF–1.2M

Select item 771848017.

Germ Granules Allow Transmission of Small RNA-Based Parental Responses in the “Germ Plasm”

Itamar Lev, Oded Rechavi

iScience. 2020 Dec 18; 23(12): 101831. Published online 2020 Nov 19. doi: 10.1016/j.isci.2020.101831

PMCID:: PMC7718480

Abstract Article PDF–1.1M

Select item 760328918.

A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans

Alicia K. Rogers, Carolyn M. Phillips

Cell Rep. Author manuscript; available in PMC 2020 Oct 31.

Published in final edited form as: Cell Rep. 2020 Oct 20; 33(3): 108279. doi: 10.1016/j.celrep.2020.108279

PMCID:: PMC7603289

Abstract Article PDF–1.5M

Select item 731613819.

Germ Granules Coordinate RNA-based Epigenetic Inheritance Pathways

Anne E. Dodson, Scott Kennedy

Dev Cell. Author manuscript; available in PMC 2020 Sep 23.

Published in final edited form as: Dev Cell. 2019 Sep 23; 50(6): 704–715.e4. Published online 2019 Aug 8. doi: 10.1016/j.devcel.2019.07.025

PMCID:: PMC7316138

Abstract Article PDF–1.8M

Select item 727222720.

Small RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

Giorgia Barucci, Eric Cornes, Meetali Singh, Blaise Li, Martino Ugolini, Aleksei Samolygo, Celine Didier, Florent Dingli, Damarys Loew, Piergiuseppe Quarato, Germano Cecere

Nat Cell Biol. Author manuscript; available in PMC 2020 Aug 3.

Published in final edited form as: Nat Cell Biol. 2020 Feb; 22(2): 235–245. Published online 2020 Feb 3. doi: 10.1038/s41556-020-0462-7