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Select item 112584801.

Combinatorial transcriptomic and genetic dissection of insulin/IGF‐1 signaling‐regulated longevity in Caenorhabditis elegans

Seokjin Ham, Sieun S. Kim, Sangsoon Park, Hyunwoo C. Kwon, Seokjun G. Ha, Yunkyu Bae, Gee‐Yoon Lee, Seung‐Jae V. Lee

Aging Cell. 2024 Jul; 23(7): e14151. Published online 2024 Mar 26. doi: 10.1111/acel.14151

PMCID:: PMC11258480

Abstract Article PDF–1.4M

Select item 112109132.

PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins

Hui-Chen Hsieh, I-Hsiang Huang, Shao-Wen Chang, Po-Lin Chen, Yu-Cheng Su, Shuying Wang, Wei-Jiun Tsai, Ping-Hung Chen, Raffi V. Aroian, Chang-Shi Chen

Autophagy. 2024; 20(6): 1335–1358. Published online 2024 Jan 23. doi: 10.1080/15548627.2024.2306655

PMCID:: PMC11210913

Abstract Article PDF–7.6M

Select item 109967983.

DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans

Alyssa Johnson, Cristian Ricaurte-Perez, P. Wall, Olga Dubuisson, K. Bohnert

Version 1. Res Sq. Preprint. 2024 Mar 29. doi: 10.21203/rs.3.rs-4049366/v1

PMCID:: PMC10996798

Abstract Article PDF–1.6M

Select item 109463304.

Cell non-autonomous control of autophagy and metabolism by glial cells

Melissa G. Metcalf, Samira Monshietehadi, Arushi Sahay, Jenni Durieux, Ashley E. Frakes, Martina Velichkovska, Cesar Mena, Amelia Farinas, Melissa Sanchez, Andrew Dillin

iScience. 2024 Apr 19; 27(4): 109354. Published online 2024 Feb 28. doi: 10.1016/j.isci.2024.109354

PMCID:: PMC10946330

Abstract Article PDF–7.6M

Select item 109426435.

Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis in C. elegans

Benson Otarigho, Anna Frances Butts, Alejandro Aballay

eLife. 2024; 12: RP90051. Published online 2024 Mar 6. doi: 10.7554/eLife.90051

PMCID:: PMC10942643

Abstract Article PDF–2.1M

Select item 108029526.

Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly

Marcos Schaan Profes, Araven Tiroumalechetty, Neel Patel, Stephanie S. Lauar, Simone Sidoli, Peri T. Kurshan

PLoS Biol. 2024 Jan; 22(1): e3002466. Published online 2024 Jan 22. doi: 10.1371/journal.pbio.3002466

PMCID:: PMC10802952

Abstract Article PDF–2.7M

Select item 107978067.

A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan

Manish Chamoli, Anand Rane, Anna Foulger, Shankar J. Chinta, Azar Asadi Shahmirzadi, Caroline Kumsta, Dhanya K. Nambiar, David Hall, Angelina Holcom, Suzanne Angeli, Minna Schmidt, Sharon Pitteri, Malene Hansen, Gordon J. Lithgow, Julie K. Andersen

Nat Aging. Author manuscript; available in PMC 2024 Jan 19.

Published in final edited form as: Nat Aging. 2023 Dec; 3(12): 1529–1543. Published online 2023 Nov 13. doi: 10.1038/s43587-023-00524-9

PMCID:: PMC10797806

Abstract Article PDF–3.4M

Select item 105997258.

Neuronal HLH-30/TFEB modulates thermoresistance and longevity in C. elegans

Louis R. Lapierre

Aging (Albany NY) 2023 Oct 15; 15(19): 9892–9893. Published online 2023 Oct 12. doi: 10.18632/aging.204849

PMCID:: PMC10599725

Abstract Article PDF–372K

Select item 105235629.

Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity

Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2221553120. Published online 2023 Sep 18. doi: 10.1073/pnas.2221553120

Correction in:: Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2318184120.

PMCID:: PMC10523562

Abstract Article PDF–1.7M

Select item 1050193710.

Eicosapentaenoic acid influences the pathogenesis of Candidaalbicans in Caenorhabditiselegans via inhibition of hyphal formation and stimulation of the host immune response

N. Z. Mokoena, H. Steyn, A. Hugo, T. Dix-Peek, C. Dickens, O. M. N. Gcilitshana, O. Sebolai, J. Albertyn, C. H. Pohl

Med Microbiol Immunol. 2023; 212(5): 349–368. Published online 2023 Sep 6. doi: 10.1007/s00430-023-00777-6

PMCID:: PMC10501937

Abstract Article PDF–3.9M

Select item 1045739011.

Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans

Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Côté, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S.R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki

Nat Commun. 2023; 14: 5214. Published online 2023 Aug 25. doi: 10.1038/s41467-023-40857-y

PMCID:: PMC10457390

Abstract Article PDF–3.3M

Select item 1039329812.

Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

Maria I Lazaro-Pena, Adam B Cornwell, Carlos A Diaz-Balzac, Ritika Das, Zachary C Ward, Nicholas Macoretta, Juilee Thakar, Andrew V Samuelson

eLife. 2023; 12: e85792. Published online 2023 Jun 20. doi: 10.7554/eLife.85792

PMCID:: PMC10393298

Abstract Article PDF–6.8M

Select item 1028773813.

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee

Nat Commun. 2023; 14: 3716. Published online 2023 Jun 22. doi: 10.1038/s41467-023-39393-6

PMCID:: PMC10287738

Abstract Article PDF–1.7M

Select item 1023644514.

Increased Alcohol Dehydrogenase 1 activity promotes longevity

Abbas Ghaddar, Vinod K. Mony, Swarup Mishra, Samuel Berhanu, James C. Johnson, Elisa Enriquez-Hesles, Emma Harrison, Aaroh Patel, Mary Kate Horak, Jeffrey S. Smith, Eyleen J. O’Rourke

Curr Biol. Author manuscript; available in PMC 2024 Mar 27.

Published in final edited form as: Curr Biol. 2023 Mar 27; 33(6): 1036–1046.e6. Published online 2023 Feb 17. doi: 10.1016/j.cub.2023.01.059

PMCID:: PMC10236445

Abstract Article PDF–1.3M

Select item 1015423615.

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Wenming Huang, Chun Kew, Stephanie de Alcantara Fernandes, Anna Löhrke, Lynn Han, Constantinos Demetriades, Adam Antebi

Nat Aging. 2022; 2(9): 796–808. Published online 2022 Sep 19. doi: 10.1038/s43587-022-00275-z

PMCID:: PMC10154236

Abstract Article PDF–17M

Select item 1008652016.

Age‐dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans

Konstantinos Palikaras, Meropi Mari, Christina Ploumi, Andrea Princz, George Filippidis, Nektarios Tavernarakis

Aging Cell. 2023 Apr; 22(4): e13788. Published online 2023 Jan 31. doi: 10.1111/acel.13788

PMCID:: PMC10086520

Abstract Article PDF–2.8M

Select item 1001405217.

Neuronal HLH‐30/TFEB modulates peripheral mitochondrial fragmentation to improve thermoresistance in Caenorhabditis elegans

Shi Quan Wong, Catherine J. Ryan, Dennis M. Bonal, Joslyn Mills, Louis R. Lapierre

Aging Cell. 2023 Mar; 22(3): e13741. Published online 2022 Nov 23. doi: 10.1111/acel.13741

PMCID:: PMC10014052

Abstract Article PDF–4.9M

Select item 998047218.

Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity

Shaosong Yang, Tiejian Nie, Hua She, Kai Tao, Fangfang Lu, Yiman Hu, Lu Huang, Lin Zhu, Dayun Feng, Dan He, Jing Qi, Thomas Kukar, Long Ma, Zixu Mao, Qian Yang

Autophagy. 2023; 19(3): 822–838. Published online 2022 Aug 8. doi: 10.1080/15548627.2022.2105561