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Select item 112951461.

Generation of precision preclinical cancer models using regulated in vivo base editing

Alyna Katti, Adrián Vega-Pérez, Miguel Foronda, Jill Zimmerman, Maria Paz Zafra, Elizabeth Granowsky, Sukanya Goswami, Eric E. Gardner, Bianca J. Diaz, Janelle M Simon, Alexandra Wuest, Wei Luan, Maria Teresa Calvo Fernandez, Anastasia P. Kadina, John A Walker, II, Kevin Holden, Scott W. Lowe, Francisco J. Sánchez Rivera, Lukas E. Dow

Nat Biotechnol. Author manuscript; available in PMC 2024 Aug 2.

Published in final edited form as: Nat Biotechnol. 2024 Mar; 42(3): 437–447. Published online 2023 Aug 10. doi: 10.1038/s41587-023-01900-x

PMCID:: PMC11295146

Abstract Article PDF–2.6M

Select item 110685622.

Cell competition promotes metastatic intestinal cancer through a multistage process

Ana Krotenberg Garcia, Mario Ledesma-Terrón, Maria Lamprou, Joyce Vriend, Merel Elise van Luyk, Saskia Jacoba Elisabeth Suijkerbuijk

iScience. 2024 May 17; 27(5): 109718. Published online 2024 Apr 11. doi: 10.1016/j.isci.2024.109718

PMCID:: PMC11068562

Abstract Article PDF–6.0M

Select item 110613473.

Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice

Yi Lv, Qian Wang, Chensheng Lin, Xi Zheng, Yanding Zhang, Xuefeng Hu

Front Cell Dev Biol. 2024; 12: 1376814. Published online 2024 Apr 17. doi: 10.3389/fcell.2024.1376814

PMCID:: PMC11061347

Abstract Article PDF–11M

Select item 109802794.

Extra centrosomes delay DNA damage–driven tumorigenesis

Vincent Z. Braun, Gerlinde Karbon, Fabian Schuler, Marina A. Schapfl, Johannes G. Weiss, Paul Y. Petermann, Diana C.J. Spierings, Andrea E. Tijhuis, Floris Foijer, Verena Labi, Andreas Villunger

Sci Adv. 2024 Mar 29; 10(13): eadk0564. Published online 2024 Mar 29. doi: 10.1126/sciadv.adk0564

PMCID:: PMC10980279

Abstract Article PDF–5.0M

Select item 109315025.

CD38 promotes hematopoietic stem cell dormancy

Liliia Ibneeva, Sumeet Pal Singh, Anupam Sinha, Sema Elif Eski, Rebekka Wehner, Luise Rupp, Iryna Kovtun, Juan Alberto Pérez-Valencia, Alexander Gerbaulet, Susanne Reinhardt, Manja Wobus, Malte von Bonin, Jaime Sancho, Frances Lund, Andreas Dahl, Marc Schmitz, Martin Bornhäuser, Triantafyllos Chavakis, Ben Wielockx, Tatyana Grinenko

PLoS Biol. 2024 Feb; 22(2): e3002517. Published online 2024 Feb 29. doi: 10.1371/journal.pbio.3002517

PMCID:: PMC10931502

Abstract Article PDF–3.7M

Select item 109224056.

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

Zhuxuan Li, Xueqian Zhuang, Chun-Hao Pan, Yan Yan, Rohit Thummalapalli, Jill Hallin, Stefan Torborg, Anupriya Singhal, Jason C. Chang, Eusebio Manchado, Lukas E. Dow, Rona Yaeger, James G. Christensen, Scott W. Lowe, Charles M. Rudin, Simon Joost, Tuomas Tammela

Cancer Discov. Author manuscript; available in PMC 2024 Aug 8.

Published in final edited form as: Cancer Discov. 2024 Feb 8; 14(2): 308–325. doi: 10.1158/2159-8290.CD-23-0289

PMCID:: PMC10922405

Abstract Article PDF–3.9M

Select item 109120177.

LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression

Yanan Li, Jonny Mendoza-Castrejon, Riddhi M. Patel, Emily B. Casey, Elisabeth Denby, David Bryder, Jeffrey A. Magee

Leukemia. 2024; 38(3): 648–651. Published online 2024 Feb 6. doi: 10.1038/s41375-024-02167-0

PMCID:: PMC10912017

Article PDF–1.0M

Select item 109083738.

Lin28 reprograms inner ear glia to a neuronal fate

Judith S. Kempfle, Ngoc-Nhi C. Luu, Marco Petrillo, Reef Al-Asad, Andrea Zhang, Albert S. B. Edge

Stem Cells. Author manuscript; available in PMC 2024 Mar 2.

Published in final edited form as: Stem Cells. 2020 Jul; 38(7): 890–903. Published online 2020 Apr 30. doi: 10.1002/stem.3181

PMCID:: PMC10908373

Abstract Article PDF–1.5M

Select item 109057469.

BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation

Rachel E. Musa, Kaitlyn L. Lester, Gabrielle Quickstad, Sara Vardabasso, Trevor V. Shumate, Ryan T. Salcido, Kai Ge, Karl B. Shpargel

Development. 2024 Jan 15; 151(2): dev202110. Published online 2024 Jan 24. doi: 10.1242/dev.202110

PMCID:: PMC10905746

Abstract Article

Select item 1088883710.

Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice

Rebekka Vogtmann, Alina Riedel, Ivanka Sassmannshausen, Sarah Langer, Elisabeth Kühnel-Terjung, Rainer Kimmig, Hubert Schorle, Elke Winterhager, Alexandra Gellhaus

Int J Mol Sci. 2024 Feb; 25(4): 2040. Published online 2024 Feb 7. doi: 10.3390/ijms25042040

PMCID:: PMC10888837

Abstract Article PDF–6.7M

Select item 1086666211.

KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis

Jackelyn R. Raymundo, Hui Zhang, Giovanni Smaldone, Wenjuan Zhu, Kathleen E. Daly, Benjamin J. Glennon, Giovanni Pecoraro, Marco Salvatore, William A. Devine, Cecilia W. Lo, Luigi Vitagliano, Alexander G. Marneros

J Clin Invest. 2024 Feb 15; 134(4): e174138. Published online 2023 Dec 19. doi: 10.1172/JCI174138

PMCID:: PMC10866662

Abstract Article PDF–143M

Select item 1083968912.

Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice

Salli Talvi, Johanna Jokinen, Kalle Sipilä, Pekka Rappu, Fu-Ping Zhang, Matti Poutanen, Pia Rantakari, Jyrki Heino

iScience. 2024 Feb 16; 27(2): 108914. Published online 2024 Jan 15. doi: 10.1016/j.isci.2024.108914

PMCID:: PMC10839689

Abstract Article PDF–5.9M

Select item 1083194713.

Extracellular matrix protein composition dynamically changes during murine forelimb development

Kathryn R. Jacobson, Aya M. Saleh, Sarah N. Lipp, Chengzhe Tian, Audrey R. Watson, Callan M. Luetkemeyer, Alexander R. Ocken, Sabrina L. Spencer, Tamara L. Kinzer-Ursem, Sarah Calve

iScience. 2024 Feb 16; 27(2): 108838. Published online 2024 Jan 9. doi: 10.1016/j.isci.2024.108838

PMCID:: PMC10831947

Abstract Article PDF–7.3M

Select item 1076102014.

hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression

Liang Liu, Wenze Huang

Cancer Biol Ther. 2023; 24(1): 2274120. Published online 2023 Nov 18. doi: 10.1080/15384047.2023.2274120

PMCID:: PMC10761020

Abstract Article PDF–5.1M

Select item 1070341915.

Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. Henderson

PLoS Genet. 2023 Nov; 19(11): e1010777. Published online 2023 Nov 27. doi: 10.1371/journal.pgen.1010777

PMCID:: PMC10703419

Abstract Article PDF–9.6M

Select item 1068283216.

Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney

Verónica Miguel, Carlos Rey-Serra, Jessica Tituaña, Belén Sirera, Elena Alcalde-Estévez, J. Ignacio Herrero, Irene Ranz, Laura Fernández, Carolina Castillo, Lucía Sevilla, James Nagai, Katharina C. Reimer, Jitske Jansen, Rafael Kramann, Ivan G. Costa, Ana Castro, David Sancho, José Miguel Rodríguez González-Moro, Santiago Lamas

Redox Biol. 2023 Dec; 68: 102957. Published online 2023 Nov 3. doi: 10.1016/j.redox.2023.102957

PMCID:: PMC10682832

Abstract Article PDF–11M

Select item 1066297217.

Myocardial equation M1

-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation

Yidong Wang, Pengfei Lu, Bingruo Wu, Dario F. Riascos-Bernal, Nicholas E.S. Sibinga, Tomas Valenta, Konrad Basler, Bin Zhou

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Nov 21.

Published in final edited form as: J Mol Cell Cardiol. 2018 Oct; 123: 150–158. Published online 2018 Sep 8. doi: 10.1016/j.yjmcc.2018.09.001

PMCID:: PMC10662972

Abstract Article PDF–2.2M

Select item 1065591818.

The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis

Jingyue Xu, Han Liu, Yu Lan, Rulang Jiang

Development. 2022 Nov 1; 149(21): dev200667. Published online 2022 Oct 28. doi: 10.1242/dev.200667

PMCID:: PMC10655918

Abstract Article

Select item 1054730019.

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou

J Am Heart Assoc. 2023 Sep 19; 12(18): e029683. Published online 2023 Sep 13. doi: 10.1161/JAHA.123.029683

PMCID:: PMC10547300

Abstract Article PDF–41M

Select item 1053917320.

Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis

Natalia J. Gurule, Kenneth C. Malcolm, Chelsea Harris, Jennifer R. Knapp, Brian P. O’Connor, Jazalle McClendon, William J. Janssen, Frank Fang Yao Lee, Caitlin Price, Jackson Osaghae-Nosa, Emily A. Wheeler, Christine M. McMahon, Eric M. Pietras, Daniel A. Pollyea, Scott Alper

Leukemia. 2023; 37(10): 2115–2124. Published online 2023 Aug 17. doi: 10.1038/s41375-023-02007-7

PMCID:: PMC10539173

Abstract Article PDF–2.8M

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