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Select item 108423461.

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

Alexander Ferrena, Jichuan Wang, Ranxin Zhang, Burcu Karadal-Ferrena, Waleed Al-Hardan, Swapnil Singh, Hasibagan Borjihan, Edward L. Schwartz, Hongling Zhao, Maja H. Oktay, Rui Yang, David S Geller, Bang H Hoang, Deyou Zheng

Mol Cancer Ther. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Mol Cancer Ther. 2024 Feb 1; 23(2): 223–234. doi: 10.1158/1535-7163.MCT-23-0173

PMCID:: PMC10842346

Abstract Article PDF–1.6M

Select item 97540042.

SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis

Dibyendu K. Panda, Xiuying Bai, Yan Zhang, Nicholas A. Stylianesis, Antonis E. Koromilas, Mark L. Lipman, Andrew C. Karaplis

J Clin Invest. 2022 Dec 15; 132(24): e153943. Published online 2022 Dec 15. doi: 10.1172/JCI153943

PMCID:: PMC9754004

Abstract Article PDF–7.1M

Select item 76695623.

Keratin 13 Deficiency Causes White Sponge Nevus in Mice

Laura Simonson, Samantha Vold, Colton Mowers, Randall J Massey, Irene M Ong, B. Jack Longley, Hao Chang

Dev Biol. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Dev Biol. 2020 Dec 1; 468(1-2): 146–153. Published online 2020 Aug 3. doi: 10.1016/j.ydbio.2020.07.016

PMCID:: PMC7669562

Abstract Article PDF–2.2M

Select item 71928444.

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

Sonia Rodriguez, Christina Abundis, Francesco Boccalatte, Purvi Mehrotra, Mark Y. Chiang, Mary A. Yui, Lin Wang, Huajia Zhang, Amy Zollman, Ricardo Bonfim-Silva, Andreas Kloetgen, Joycelynne Palmer, George Sandusky, Mark Wunderlich, Mark H. Kaplan, James C. Mulloy, Guido Marcucci, Iannis Aifantis, Angelo A. Cardoso, Nadia Carlesso

Leukemia. 2020; 34(5): 1241–1252. Published online 2019 Nov 26. doi: 10.1038/s41375-019-0653-z

PMCID:: PMC7192844

Abstract Article PDF–2.4M

Select item 71711375.

S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo

Hsueh-Hsiao Wang, Yi-Nan Lee, Cheng-Huang Su, Kuo-Tung Shu, Wen-Ting Liu, Chin-Ling Hsieh, Hung-I Yeh, Yih-Jer Wu

Sci Rep. 2020; 10: 6646. Published online 2020 Apr 20. doi: 10.1038/s41598-020-63716-y

PMCID:: PMC7171137

Abstract Article PDF–5.7M

Select item 67542946.

Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12

Bin Zhao, Kogulan Yoganathan, LiQi Li, Jan Y. Lee, Juan Carlos Zúñiga-Pflücker, Paul E. Love

Nat Immunol. Author manuscript; available in PMC 2020 Feb 26.

Published in final edited form as: Nat Immunol. 2019 Oct; 20(10): 1381–1392. Published online 2019 Aug 26. doi: 10.1038/s41590-019-0469-z

PMCID:: PMC6754294

Abstract Article PDF–2.4M

Select item 63935987.

A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation

Zhengke Li, Dong-Lai Qi, Hardeep P. Singh, Yue Zou, Binghui Shen, David Cobrinik

J Biol Chem. 2019 Feb 22; 294(8): 2961–2969. Published online 2019 Jan 14. doi: 10.1074/jbc.AC118.006041

PMCID:: PMC6393598

Abstract Article PDF–1.2M

Select item 63752238.

SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

Ce Li, Lutao Du, Yidan Ren, Xiaoyan Liu, Qinlian Jiao, Donghai Cui, Mingxin Wen, Chuanxin Wang, Guangwei Wei, Yunshan Wang, Aiguo Ji, Qin Wang

J Exp Clin Cancer Res. 2019; 38: 76. Published online 2019 Feb 13. doi: 10.1186/s13046-019-1069-3

PMCID:: PMC6375223

Abstract Article PDF–9.9M

Select item 58635419.

Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2

Shihao Zhang, Qinghua Chen, Qingxu Liu, Yuxi Li, Xiufeng Sun, Lixin Hong, Suyuan Ji, Chengyan Liu, Jing Geng, Weiji Zhang, Zhonglei Lu, Zhen-Yu Yin, Yuanyuan Zeng, Kwang-Huei Lin, Qiao Wu, Qiyuan Li, Keiko Nakayama, Keiich I. Nakayama, Xianming Deng, Randy L. Johnson, Liang Zhu, Daming Gao, Lanfen Chen, Dawang Zhou

Cancer Cell. Author manuscript; available in PMC 2018 Mar 22.

Published in final edited form as: Cancer Cell. 2017 May 8; 31(5): 669–684.e7. doi: 10.1016/j.ccell.2017.04.004

PMCID:: PMC5863541

Abstract Article PDF–5.0M

Select item 572496010.

SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer

W Lu, S Liu, B Li, Y Xie, MG Izban, BR Ballard, SA Sathyanarayana, SE Adunyah, RJ Matusik, Z Chen

Oncogene. Author manuscript; available in PMC 2017 Dec 11.

Published in final edited form as: Oncogene. 2017 Mar; 36(10): 1364–1373. Published online 2016 Nov 21. doi: 10.1038/onc.2016.300

PMCID:: PMC5724960

Abstract Article PDF–2.0M

Select item 556842811.

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

Hi-Jai R. Shin, Hyunkyung Kim, Sungryong Oh, Jun-Gi Lee, Minjung Kee, Hyun-Jeong Ko, Mi-Na Kweon, Kyoung-Jae Won, Sung Hee Baek

Nature. Author manuscript; available in PMC 2017 Aug 23.

Published in final edited form as: Nature. 2016 Jun 23; 534(7608): 553–557. Published online 2016 Jun 15. doi: 10.1038/nature18014

PMCID:: PMC5568428

Abstract Article PDF–5.2M

Select item 553206512.

Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist

Diane Ruan, Jiabei He, Chien-Feng Li, Hong-Jen Lee, Jingxuan Liu, Hui-Kuan Lin, Chia-Hsin Chan

Oncogene. Author manuscript; available in PMC 2017 Sep 27.

Published in final edited form as: Oncogene. 2017 Jul 27; 36(30): 4299–4310. Published online 2017 Mar 27. doi: 10.1038/onc.2017.64

PMCID:: PMC5532065

Abstract Article PDF–2.3M

Select item 513633113.

“AMPKα2 Regulates Bladder Cancer Growth Through SKP2-mediated Degradation of p27”

Stavros Kopsiaftis, Katie L. Sullivan, Isha Garg, John A. Taylor, III, Kevin P. Claffey

Mol Cancer Res. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Mol Cancer Res. 2016 Dec; 14(12): 1182–1194. Published online 2016 Sep 16. doi: 10.1158/1541-7786.MCR-16-0111

PMCID:: PMC5136331

Abstract Article PDF–1.0M

Select item 485897014.

Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis

Hongling Zhao, Hongbo Wang, Frederick Bauzon, Zhonglei Lu, Hao Fu, Jinhua Cui, Liang Zhu

J Biol Chem. 2016 May 6; 291(19): 10201–10209. Published online 2016 Mar 10. doi: 10.1074/jbc.M116.718049

PMCID:: PMC4858970

Abstract Article PDF–4.1M

Select item 474719015.

Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model

Xuesen Li, Noriko N. Yokoyama, Saiyang Zhang, Lina Ding, Hong-min Liu, Michael B. Lilly, Dan Mercola, Xiaolin Zi

Oncotarget. 2015 Dec 8; 6(39): 41809–41824. Published online 2015 Oct 19. doi: 10.18632/oncotarget.6166

PMCID:: PMC4747190

Abstract Article PDF–8.1M

Select item 461397616.

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion

Maria L. Golson, Jennifer C. Dunn, Matthew F. Maulis, Prasanna K. Dadi, Anna B. Osipovich, Mark A. Magnuson, David A. Jacobson, Maureen Gannon

Diabetes. 2015 Nov; 64(11): 3829–3838. Published online 2015 Aug 6. doi: 10.2337/db15-0465

PMCID:: PMC4613976

Abstract Article PDF–1.9M

Select item 450016917.

Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition, polyploidy and tumourigenesis

Dazhi Xu, Chien-Feng Li, Xian Zhang, Zhaohui Gong, Chia-Hsin Chan, Szu-Wei Lee, Guoxiang Jin, Abdol-Hossein Rezaeian, Fei Han, Jing Wang, Wei-Lei Yang, Zi-Zhen Feng, Wei Chen, Ching-Yuan Wu, Ying-Jan Wang, Lu-Ping Chow, Xiao-Feng Zhu, Yi-Xin Zeng, Hui-Kuan Lin

Nat Commun. Author manuscript; available in PMC 2015 Sep 30.

Published in final edited form as: Nat Commun. 2015; 6: 6641. Published online 2015 Mar 30. doi: 10.1038/ncomms7641

PMCID:: PMC4500169

Abstract Article PDF–1.3M

Select item 438584718.

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice

Salvatore Delogu, Chunmei Wang, Antonio Cigliano, Kirsten Utpatel, Marcella Sini, Thomas Longerich, Nina Waldburger, Kai Breuhahn, Lijie Jiang, Silvia Ribback, Frank Dombrowski, Matthias Evert, Xin Chen, Diego F. Calvisi

Oncotarget. 2015 Feb; 6(4): 2222–2234. Published online 2014 Dec 10. doi: 10.18632/oncotarget.2945

PMCID:: PMC4385847

Abstract Article PDF–2.9M

Select item 398215019.

Skp2 suppresses apoptosis in Rb1 deficient tumors by limiting E2F1 activity

Zhonglei Lu, Frederick Bauzon, Hao Fu, Jinhua Cui, Hongling Zhao, Keiko Nakayama, Keiich I. Nakayama, Liang Zhu

Nat Commun. Author manuscript; available in PMC 2014 Sep 17.

Published in final edited form as: Nat Commun. 2014; 5: 3463. Published online 2014 Mar 17. doi: 10.1038/ncomms4463

PMCID:: PMC3982150

Abstract Article PDF–2.0M

Select item 394590820.

F-box Protein FBXL16 Binds PP2A-B55α and Regulates Differentiation of Embryonic Stem Cells along the FLK1+ Lineage

Narimon Honarpour, Christopher M. Rose, Justin Brumbaugh, Jody Anderson, Robert L. J. Graham, Michael J. Sweredoski, Sonja Hess, Joshua J. Coon, Raymond J. Deshaies

Mol Cell Proteomics. 2014 Mar; 13(3): 780–791. Published online 2014 Jan 5. doi: 10.1074/mcp.M113.031765

PMCID:: PMC3945908

Abstract Article PDF–995K

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