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Select item 116683511.

Clinical and Imaging Characteristics of PRPH2 Retinopathies in a Longitudinal Cohort and Diagnostic Implications

Johanna M. Seddon, Dikha De, Laura Grunenkovaite, Daniela Ferrara

Invest Ophthalmol Vis Sci. 2024 Dec; 65(14): 31. Published online 2024 Dec 18. doi: 10.1167/iovs.65.14.31

PMCID:: PMC11668351

Article PDF–7.7M

Select item 116307532.

Identifying X-chromosome variants associated with age-related macular degeneration

Michelle Grunin, Robert P Igo Jr, Yeunjoo E Song, Susan H Blanton, Margaret A Pericak-Vance, Jonathan L Haines, International Age-related Macular Degeneration Genomics Consortium

Hum Mol Genet. 2024 Dec 15; 33(24): 2085–2093. Published online 2024 Sep 26. doi: 10.1093/hmg/ddae141

PMCID:: PMC11630753

Article PDF–494K

Select item 115735223.

VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept

Deepti Sharma, Evan Lau, Yu Qin, Kathleen Jee, Murilo Rodrigues, Chuanyu Guo, Aumreetam Dinabandhu, Emma McIntyre, Shaima Salman, Yousang Hwang, Ala Moshiri, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi

Proc Natl Acad Sci U S A. 2024 Nov 12; 121(46): e2322759121. Published online 2024 Nov 5. doi: 10.1073/pnas.2322759121

PMCID:: PMC11573522

Article PDF–8.1M

Select item 115643844.

Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3

Austin T. Gregg, Tianxi Wang, Manon Szczepan, Enton Lam, Hitomi Yagi, Katherine Neilsen, Xingyan Wang, Lois E. H. Smith, Ye Sun

Angiogenesis. 2024; 27(4): 753–764. Published online 2024 Jun 26. doi: 10.1007/s10456-024-09935-7

PMCID:: PMC11564384

Article PDF–7.9M

Select item 115639185.

Inflammasome activation aggravates choroidal neovascularization

Ryan D. Makin, Ivana Apicella, Roshni Dholkawala, Shinichi Fukuda, Shuichiro Hirahara, Yoshio Hirano, Younghee Kim, Ayami Nagasaka, Yosuke Nagasaka, Siddharth Narendran, Felipe Pereira, Akhil Varshney, Shao-bin Wang, Jayakrishna Ambati, Bradley D. Gelfand

Angiogenesis. 2024; 27(4): 919–929. Published online 2024 Sep 24. doi: 10.1007/s10456-024-09949-1

PMCID:: PMC11563918

Article PDF–1.8M

Select item 115508296.

The perspective of ceRNA regulation of circadian rhythm on choroidal neovascularization

Ying Yang, Shu Su, Jia Chen, Xiaowei Yang, Shenglai Zhang, Aimin Sang

Sci Rep. 2024; 14: 27359. Published online 2024 Nov 9. doi: 10.1038/s41598-024-78479-z

PMCID:: PMC11550829

Article PDF–6.1M

Select item 115333967.

Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study

Bin Tong, Chubing Long, Jing Zhang, Xin Zhang, Zhengyang Li, Haodong Qi, Kangtai Su, Deju Zhang, Yixuan Chen, Jitao Ling, Jianping Liu, Yunwei Hu, Peng Yu

Lipids Health Dis. 2024; 23: 359. Published online 2024 Nov 4. doi: 10.1186/s12944-024-02337-0

PMCID:: PMC11533396

Article PDF–3.0M

Select item 114906178.

Retinal pigment epithelium-specific ablation of GPx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration

Kunihiro Azuma, Takafumi Suzuki, Kenta Kobayashi, Masako Nagahara, Hirotaka Imai, Akiko Suga, Takeshi Iwata, Tomoyasu Shiraya, Makoto Aihara, Takashi Ueta

Cell Death Dis. 2024 Oct; 15(10): 763. Published online 2024 Oct 19. doi: 10.1038/s41419-024-07150-2

PMCID:: PMC11490617

Article PDF–3.9M

Select item 114648079.

Genome-wide association study of subfoveal choroidal thickness in a longitudinal cohort of older adults

Hyeong Min Kim, Kwangsic Joo, Minji Kim, Young Joo Park, Ji Won Han, Ki Woong Kim, Sejoon Lee, Se Joon Woo

Sci Rep. 2024; 14: 23545. Published online 2024 Oct 9. doi: 10.1038/s41598-024-73094-4

PMCID:: PMC11464807

Article PDF–3.0M

Select item 1140747810.

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization

Ying Yang, Shenglai Zhang, Shu Su, Xiaowei Yang, Jia Chen, Aimin Sang

Invest Ophthalmol Vis Sci. 2024 Sep; 65(11): 21. Published online 2024 Sep 13. doi: 10.1167/iovs.65.11.21

PMCID:: PMC11407478

Article PDF–10M

Select item 1140490611.

Causal influence of plasma metabolites on age-related macular degeneration: A Mendelian randomization study

Tao Wang, Chun Huang, Jinshuai Li, Xiangjian Wu, Xiaoyan Fu, Yimin Hu, Geping Wu, Chunfeng Yang, Sheng Chen

Medicine (Baltimore) 2024 Sep 13; 103(37): e39400. Published online 2024 Sep 13. doi: 10.1097/MD.0000000000039400

PMCID:: PMC11404906

Article PDF–1.4M

Select item 1139631312.

The Impact of ARMS2 (rs10490924), VEGFA (rs3024997), TNFRSF1B (rs1061622), TNFRSF1A (rs4149576), and IL1B1 (rs1143623) Polymorphisms and Serum Levels on Age-Related Macular Degeneration Development and Therapeutic Responses

Dzastina Cebatoriene, Alvita Vilkeviciute, Greta Gedvilaite-Vaicechauskiene, Monika Duseikaite, Akvile Bruzaite, Loresa Kriauciuniene, Dalia Zaliuniene, Rasa Liutkeviciene

Int J Mol Sci. 2024 Sep; 25(17): 9750. Published online 2024 Sep 9. doi: 10.3390/ijms25179750

PMCID:: PMC11396313

Article PDF–1.6M

Select item 1132228913.

JR5558 mice are a reliable model to investigate subretinal fibrosis

Yashar Seyed-Razavi, So-Ra Lee, Jiawen Fan, Weiyong Shen, Elisa E. Cornish, Mark C. Gillies

Sci Rep. 2024; 14: 18752. Published online 2024 Aug 13. doi: 10.1038/s41598-024-66068-z

PMCID:: PMC11322289

Article PDF–9.0M

Select item 1126247814.

Altered Elastin Turnover, Immune Response, and Age-Related Retinal Thinning in a Transgenic Mouse Model With RPE-Specific HTRA1 Overexpression

Soumya Navneet, Masaaki Ishii, Bärbel Rohrer

Invest Ophthalmol Vis Sci. 2024 Jul; 65(8): 34. Published online 2024 Jul 19. doi: 10.1167/iovs.65.8.34

PMCID:: PMC11262478

Article PDF–9.2M

Select item 1125794515.

Retinoic acid related orphan receptor α is a genetic modifier that rescues retinal degeneration in a mouse model of Stargardt disease and Dry AMD

M. Akula, S. M. McNamee, Z. Love, N. Nasraty, N. P. M. Chan, M. Whalen, M. O. Avola, A. M. Olivares, B. D. Leehy, A. S. Jelcick, P. Singh, A. K. Upadhyay, D. F. Chen, N. B. Haider

Gene Ther. 2024; 31(7-8): 413–421. Published online 2024 May 16. doi: 10.1038/s41434-024-00455-z

PMCID:: PMC11257945

Article PDF–2.2M

Select item 1121625116.

Unveiling Statins and Genetics in Age-Related Macular Degeneration: The Coimbra Eye Study—Report 9

Patrícia Barreto, Cláudia Farinha, Rita Coimbra, Maria Luz Cachulo, Joana Barbosa Melo, Yara Lechanteur, Carel B. Hoyng, José Cunha-Vaz, Rufino Silva

Invest Ophthalmol Vis Sci. 2024 Jun; 65(6): 38. Published online 2024 Jun 27. doi: 10.1167/iovs.65.6.38

PMCID:: PMC11216251

Article PDF–636K

Select item 1115012817.

Role of NLRP3 Inflammasomes in Monocyte and Microglial Recruitments in Choroidal Neovascularization

Blake W. Dieckmann, Marcell E. Paguaga, Gary W. McCollum, John S. Penn, MD Imam Uddin

Immunohorizons. 2024 May; 8(5): 363–370. Published online 2024 May 22. doi: 10.4049/immunohorizons.2400025

PMCID:: PMC11150128

Article PDF–1.5M

Select item 1112749518.

Cláudia Farinha, Patrícia Barreto, Rita Coimbra, Maria Beatriz Machado, Inês Figueiredo, Maria Luz Cachulo, José Cunha-Vaz, Rufino Silva

Invest Ophthalmol Vis Sci. 2024 May; 65(5): 35. Published online 2024 May 22. doi: 10.1167/iovs.65.5.35

PMCID:: PMC11127495

Article PDF–1.0M

Select item 1111509819.

Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization

Julie Lecomte, Krystel Louis, Benoit Detry, Silvia Blacher, Vincent Lambert, Sandrine Bekaert, Carine Munaut, Jenny Paupert, Pierre Blaise, Jean-Michel Foidart, Jean-Marie Rakic, Stephen M. Krane, Agnès Noel

Cell Mol Life Sci. 2011 Feb; 68(4): 677–686. Published online 2010 Aug 11. doi: 10.1007/s00018-010-0476-6

PMCID:: PMC11115098

Article PDF–657K

Select item 1105980420.

CFH Haploinsufficiency and Complement Alterations in Early-Onset Macular Degeneration

Rayne R. Lim, Sharlene Shirali, Jessica Rowlan, Abbi L. Engel, Marcos Nazario,, Jr., Kelie Gonzalez, Aspen Tong, Jay Neitz, Maureen Neitz, Jennifer R. Chao

Invest Ophthalmol Vis Sci. 2024 Apr; 65(4): 43. Published online 2024 Apr 29. doi: 10.1167/iovs.65.4.43