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Select item 68322571.

Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy

Aaron Tan, Maria V. Babak, Gopalakrishnan Venkatesan, Clarissa Lim, Karl-Norbert Klotz, Deron Raymond Herr, Siew Lee Cheong, Stephanie Federico, Giampiero Spalluto, Wei-Yi Ong, Yu Zong Chen, Jason Siau Ee Loo, Giorgia Pastorin

Molecules. 2019 Oct; 24(20): 3661. Published online 2019 Oct 11. doi: 10.3390/molecules24203661

PMCID:: PMC6832257

Abstract Article PDF–2.8M

Select item 66788492.

Revealing Adenosine A_2A-Dopamine D₂ Receptor Heteromers in Parkinson’s Disease Post-Mortem Brain through a New AlphaScreen-Based Assay

Víctor Fernández-Dueñas, Maricel Gómez-Soler, Marta Valle-León, Masahiko Watanabe, Isidre Ferrer, Francisco Ciruela

Int J Mol Sci. 2019 Jul; 20(14): 3600. Published online 2019 Jul 23. doi: 10.3390/ijms20143600

PMCID:: PMC6678849

Abstract Article PDF–1.8M

Select item 31460963.

Agonist-bound adenosine A_2A receptor structures reveal common features of GPCR activation

Guillaume Lebon, Tony Warne, Patricia C. Edwards, Kirstie Bennett, Christopher J. Langmead, Andrew G.W. Leslie, Christopher G. Tate

Nature. Author manuscript; available in PMC 2011 Dec 23.

Published in final edited form as: Nature. 2011 May 18; 474(7352): 521–525. Published online 2011 May 18. doi: 10.1038/nature10136

PMCID:: PMC3146096

Article PDF–2.0M

Select item 30868114.

Structure of an agonist-bound human A_2A adenosine receptor

Fei Xu, Huixian Wu, Vsevolod Katritch, Gye Won Han, Kenneth A. Jacobson, Zhan-Guo Gao, Vadim Cherezov, Raymond C. Stevens

Science. Author manuscript; available in PMC 2012 Apr 15.

Published in final edited form as: Science. 2011 Apr 15; 332(6027): 322–327. Published online 2011 Mar 10. doi: 10.1126/science.1202793

PMCID:: PMC3086811

Abstract Article PDF–1.4M

Select item 25869715.

The 2.6 Å Crystal Structure of a Human A_2A Adenosine Receptor Bound to an Antagonist

Veli-Pekka Jaakola, Mark T. Griffith, Michael A. Hanson, Vadim Cherezov, Ellen Y.T. Chien, J. Robert Lane, Adriaan P. Ijzerman, Raymond C. Stevens

Science. Author manuscript; available in PMC 2009 Nov 21.

Published in final edited form as: Science. 2008 Nov 21; 322(5905): 1211–1217. Published online 2008 Oct 2. doi: 10.1126/science.1164772

PMCID:: PMC2586971

Abstract Article PDF–2.4M

Select item 69476506.

The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep

Mégane Erblang, Catherine Drogou, Danielle Gomez-Merino, Arnaud Metlaine, Anne Boland, Jean François Deleuze, Claire Thomas, Fabien Sauvet, Mounir Chennaoui

Genes (Basel) 2019 Dec; 10(12): 1021. Published online 2019 Dec 6. doi: 10.3390/genes10121021

PMCID:: PMC6947650

Abstract Article PDF–877K

Select item 66432127.

Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages

Weiming Zhao, Li Ma, Cheng Cai, Xiaohui Gong

Int J Biol Sci. 2019; 15(8): 1571–1581. Published online 2019 Jun 2. doi: 10.7150/ijbs.34211

PMCID:: PMC6643212

Abstract Article PDF–2.2M

Select item 60961128.

Preliminary screening and analysis of metastasis-related lncRNA and co-expressed papillary thyroid carcinoma mRNA

Ming-Hua Ge, Lie-Hao Jiang, Qing-Liang Wen, Zhuo Tan, Chao Chen, Chuan-Ming Zheng, Xin Zhu, Jia-Wen Chen, Zi-Yu Zhu, Xiu-Jun Cai

Oncol Lett. 2018 Sep; 16(3): 3715–3725. Published online 2018 Jul 5. doi: 10.3892/ol.2018.9080

PMCID:: PMC6096112

Abstract Article PDF–1.7M

Select item 58851539.

The Cholangiocyte Adenosine–IL-6 Axis Regulates Survival During Biliary Cirrhosis

Elise G. Lavoie, Michel Fausther, Jessica R. Goree, Jonathan A. Dranoff

Gene Expr. 2017; 17(4): 327–340. Published online 2017 Jul 7. doi: 10.3727/105221617X15042723767876

PMCID:: PMC5885153

Abstract Article PDF–29M

Select item 541141710.

Leukocyte Expression of Type 1 and Type 2 Purinergic Receptors and Pro-Inflammatory Cytokines during Total Sleep Deprivation and/or Sleep Extension in Healthy Subjects

Mounir Chennaoui, Pierrick J. Arnal, Catherine Drogou, Damien Leger, Fabien Sauvet, Danielle Gomez-Merino

Front Neurosci. 2017; 11: 240. Published online 2017 May 2. doi: 10.3389/fnins.2017.00240

PMCID:: PMC5411417

Abstract Article PDF–775K

Select item 535852711.

The effects of exogenous lipid on THP-1 cells: an in vitro model of airway aspiration?

Yvette A. Hayman, Laura R. Sadofsky, James D. Williamson, Simon P. Hart, Alyn H. Morice

ERJ Open Res. 2017 Jan; 3(1): 00026-2016. Published online 2017 Mar 20. doi: 10.1183/23120541.00026-2016

PMCID:: PMC5358527

Abstract Article PDF–730K

Select item 505369512.

Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma

Giulia Pintarelli, Alice Dassano, Chiara E. Cotroneo, Antonella Galvan, Sara Noci, Rocco Piazza, Alessandra Pirola, Roberta Spinelli, Matteo Incarbone, Alessandro Palleschi, Lorenzo Rosso, Luigi Santambrogio, Tommaso A. Dragani, Francesca Colombo

Oncotarget. 2016 May 10; 7(19): 27889–27898. Published online 2016 Apr 2. doi: 10.18632/oncotarget.8556

PMCID:: PMC5053695

Abstract Article PDF–890K

Select item 500209113.

A_2A adenosine receptor upregulation correlates with disease activity in patients with systemic lupus erythematosus

Alessandra Bortoluzzi, Fabrizio Vincenzi, Marcello Govoni, Melissa Padovan, Annalisa Ravani, Pier Andrea Borea, Katia Varani

Arthritis Res Ther. 2016; 18(1): 192. Published online 2016 Aug 26. doi: 10.1186/s13075-016-1089-8

PMCID:: PMC5002091

Abstract Article PDF–1.5M

Select item 496785514.

MicroRNA-16 is putatively involved in the NF-κB pathway regulation in ulcerative colitis through adenosine A2a receptor (A2aAR) mRNA targeting

Ting Tian, Yu Zhou, Xiao Feng, Shicai Ye, Hao Wang, Weiyun Wu, Wenkai Tan, Caiyuan Yu, Juxiang Hu, Rong Zheng, Zonghao Chen, Xinyu Pei, Hesheng Luo

Sci Rep. 2016; 6: 30824. Published online 2016 Aug 1. doi: 10.1038/srep30824

PMCID:: PMC4967855

Abstract Article PDF–1.7M

Select item 470975815.

Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint

Toshio Hattori, Naomi Ogura, Miwa Akutsu, Mutsumi Kawashima, Suguru Watanabe, Ko Ito, Toshirou Kondoh

Mediators Inflamm. 2015; 2015: 436067. Published online 2015 Dec 29. doi: 10.1155/2015/436067

PMCID:: PMC4709758

Abstract Article PDF–2.1M

Select item 427237316.

Expression of mediators of purinergic signaling in human liver cell lines

Jessica R. Goree, Elise G. Lavoie, Michel Fausther, Jonathan A. Dranoff

Purinergic Signal. 2014 Dec; 10(4): 631–638. Published online 2014 Sep 7. doi: 10.1007/s11302-014-9425-4

PMCID:: PMC4272373

Abstract Article PDF–693K

Select item 422956817.

Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A₁ Receptor Binding in The Human Brain

Christa Hohoff, Valentina Garibotto, David Elmenhorst, Anna Baffa, Tina Kroll, Alana Hoffmann, Kathrin Schwarte, Weiqi Zhang, Volker Arolt, Jürgen Deckert, Andreas Bauer

Neuropsychopharmacology. 2014 Dec; 39(13): 2989–2999. Prepublished online 2014 Jun 19. Published online 2014 Jul 16. doi: 10.1038/npp.2014.150

PMCID:: PMC4229568

Abstract Article PDF–648K

Select item 405192418.

Role of the Na⁺/K⁺/2Cl^- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

Atsushi Shiozaki, Yoshito Nako, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Yoshinori Marunaka, Eigo Otsuji

World J Gastroenterol. 2014 Jun 14; 20(22): 6844–6859. Published online 2014 Jun 14. doi: 10.3748/wjg.v20.i22.6844