PMC Links for Nucleotide (Select 1653962552) - PMC

Select item 67426461.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 62221182.

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

Elizabeth C. Hinchy, Anja V. Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R. Hall, Georgina Bates, Thomas P. Bright, Thomas Krieg, David Carling, Michael P. Murphy

J Biol Chem. 2018 Nov 2; 293(44): 17208–17217. Published online 2018 Sep 19. doi: 10.1074/jbc.RA118.002579

PMCID:: PMC6222118

Abstract Article PDF–1.3M

Select item 62221003.

Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK)

Xin Gu, Michael D. Bridges, Yan Yan, Parker W. de Waal, X. Edward Zhou, Kelly M. Suino-Powell, H. Eric Xu, Wayne L. Hubbell, Karsten Melcher

J Biol Chem. 2018 Nov 2; 293(44): 16994–17007. Published online 2018 Sep 11. doi: 10.1074/jbc.RA118.004101

PMCID:: PMC6222100

Abstract Article PDF–1.7M

Select item 55316114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 54600385.

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

Daniela Bakula, Amelie J. Müller, Theresia Zuleger, Zsuzsanna Takacs, Mirita Franz-Wachtel, Ann-Katrin Thost, Daniel Brigger, Mario P. Tschan, Tancred Frickey, Horst Robenek, Boris Macek, Tassula Proikas-Cezanne

Nat Commun. 2017; 8: 15637. Published online 2017 May 31. doi: 10.1038/ncomms15637

PMCID:: PMC5460038

Abstract Article PDF–4.5M

Select item 469956.

Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

B Hofmann, P Nishanian, T Nguyen, P Insixiengmay, J L Fahey

Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14): 6676–6680. doi: 10.1073/pnas.90.14.6676

PMCID:: PMC46995

Summary Page Browse PDF–1.4M

Select item 58444767.

Complete mutational spectrum of the autophagy interactome: a novel class of tumor suppressor genes in myeloid neoplasms

Valeria Visconte, Bartlomiej Przychodzen, Yingchun Han, Steffan T. Nawrocki, Swapna Thota, Kevin R. Kelly, Bhumika J. Patel, Cassandra Hirsch, Anjali S. Advani, Hetty E. Carraway, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Jennifer S. Carew

Leukemia. Author manuscript; available in PMC 2018 Mar 9.

Published in final edited form as: Leukemia. 2017 Feb; 31(2): 505–510. Published online 2016 Oct 24. doi: 10.1038/leu.2016.295

PMCID:: PMC5844476

Article PDF–424K

Select item 52415538.

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

Laurent Bultot, Thomas E. Jensen, Yu-Chiang Lai, Agnete L. B. Madsen, Caterina Collodet, Samanta Kviklyte, Maria Deak, Arash Yavari, Marc Foretz, Sahar Ghaffari, Mohamed Bellahcene, Houman Ashrafian, Mark H. Rider, Erik A. Richter, Kei Sakamoto

Am J Physiol Endocrinol Metab. 2016 Oct 1; 311(4): E706–E719. Published online 2016 Aug 30. doi: 10.1152/ajpendo.00237.2016