PMC Articles for PubChem BioAssay (Select 1346157) - PMC

Select item 35200701.

A potent and orally active antagonist of multiple inhibitor of apoptosis proteins (IAPs) (SM-406/AT-406) in clinical development for cancer treatment

Qian Cai, Haiying Sun, Yuefeng Peng, Jianfeng Lu, Zaneta Nikolovska-Coleska, Donna McEachern, Liu Liu, Su Qiu, Chao-Yie Yang, Rebecca Miller, Han Yi, Tao Zhang, Duxin Sun, Sanmao Kang, Ming Guo, Lance Leopold, Dajun Yang, Shaomeng Wang

J Med Chem. Author manuscript; available in PMC 2012 Dec 12.

Published in final edited form as: J Med Chem. 2011 Apr 28; 54(8): 2714–2726. Published online 2011 Mar 28. doi: 10.1021/jm101505d

PMCID:: PMC3520070

Abstract Article PDF–2.8M

Select item 33665832.

The Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen Beresini, Nageshwar Budha, Helen Chan, Iris T. Chan, Sravanthi Cheeti, Frederick Cohen, Kurt Deshayes, Karl Doerner, S. Gail Eckhardt, Linda O. Elliott, Bainian Feng, Matthew C. Franklin, Stacy Frankovitz Reisner, Lewis Gazzard, Jason Halladay, Sarah G. Hymowitz, Hank La, Patricia LoRusso, Brigitte Maurer, Lesley Murray, Emile Plise, Clifford Quan, Jean-Philippe Stephan, Young G. Shin, Jeffrey Tom, Vickie Tsui, Joanne Um, Eugene Varfolomeev, Domagoj Vucic, Andrew J. Wagner, Heidi J.A. Wallweber, Lan Wang, Joseph Ware, Zhaoyang Wen, Harvey Wong, Jonathan M. Wong, Melisa Wong, Susan Wong, Ron Yu, Kerry Zobel, Wayne J. Fairbrother

J Med Chem. Author manuscript; available in PMC 2013 May 10.

Published in final edited form as: J Med Chem. 2012 May 10; 55(9): 4101–4113. Published online 2012 Mar 28. doi: 10.1021/jm300060k

PMCID:: PMC3366583

Abstract Article PDF–1.5M

Select item 26793753.

Potent, Orally Bioavailable Diazabicyclic Small-Molecule Mimetics of Second Mitochondria-derived Activator of Caspases

Yuefeng Peng, Haiying Sun, Zaneta Nikolovska-Coleska, Su Qiu, Chao-Yie Yang, Jianfeng Lu, Qian Cai, Han Yi, Sanmao Kang, Dajun Yang, Shaomeng Wang

J Med Chem. Author manuscript; available in PMC 2009 Dec 25.

Published in final edited form as: J Med Chem. 2008 Dec 25; 51(24): 8158–8162. doi: 10.1021/jm801254r

PMCID:: PMC2679375

Abstract Article PDF–677K

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