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Select item 109171491.

Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB₁ and CB₂ receptors

Toni Kline, Cong Xu, Faith R. Kreitzer, Dow P. Hurst, Khalil M. Eldeeb, Jim Wager-Miller, Kathleen Olivas, Seon A. Hepburn, John W. Huffman, Ken Mackie, Allyn C. Howlett, Patricia Reggio, Nephi Stella

Eur J Med Chem. Author manuscript; available in PMC 2024 Mar 6.

Published in final edited form as: Eur J Med Chem. 2023 Mar 5; 249: 115123. Published online 2023 Jan 26. doi: 10.1016/j.ejmech.2023.115123

PMCID:: PMC10917149

Abstract Article PDF–4.4M

Select item 103079392.

Role of efficacy as a determinant of locomotor activation by mu‐opioid receptor (MOR) ligands in female and male mice. II. Effects of novel MOR‐selective phenylmorphans with high‐to‐low MOR efficacy

Edna J. Santos, Nima Nassehi, Eric W. Bow, Dana R. Chambers, Eugene S. Gutman, Arthur E. Jacobson, Joshua A. Lutz, Samuel A. Marsh, Kenner C. Rice, Agnieszka Sulima, Dana E. Selley, S. Stevens Negus

Pharmacol Res Perspect. 2023 Aug; 11(4): e01111. Published online 2023 Jun 28. doi: 10.1002/prp2.1111

PMCID:: PMC10307939

Abstract Article PDF–2.6M

Select item 101783153.

Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats

David Á. Karádi, Anna Rita Galambos, Péter P. Lakatos, Joost Apenberg, Sarah K. Abbood, Mihály Balogh, Kornél Király, Pál Riba, Nariman Essmat, Edina Szűcs, Sándor Benyhe, Zoltán V. Varga, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani

Int J Mol Sci. 2023 May; 24(9): 7970. Published online 2023 Apr 27. doi: 10.3390/ijms24097970

PMCID:: PMC10178315

Abstract Article PDF–31M

Select item 98672204.

Characterization and Seasonal Modulation of Adenosine A₁ Receptors in the Arctic Ground Squirrel Brain

Zachary Carlson, Kelly Drew

Int J Mol Sci. 2023 Jan; 24(2): 1598. Published online 2023 Jan 13. doi: 10.3390/ijms24021598

PMCID:: PMC9867220

Abstract Article PDF–1.5M

Select item 98378655.

In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonists

Julie A. Marusich, Thomas F. Gamage, Yanan Zhang, Luli R. Akinfiresoye, Jenny L. Wiley

Pharmacol Biochem Behav. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Pharmacol Biochem Behav. 2022 Oct; 220: 173467. Published online 2022 Sep 22. doi: 10.1016/j.pbb.2022.173467

PMCID:: PMC9837865

Abstract Article PDF–2.0M

Select item 93649106.

Synthesis and Biological Activity of a New Series of N⁶-Arylcarbamoyl, 2-(Ar)alkynyl-N⁶-arylcarbamoyl, and N⁶-Carboxamido Derivatives of Adenosine-5′-N-ethyluronamide as A₁ and A₃ Adenosine Receptor Agonists

Pier Giovanni Baraldi, Barbara Cacciari, Maria José Pineda de Las Infantas, Romeo Romagnoli, Giampiero Spalluto, Rosaria Volpini, Stefano Costanzi, Sauro Vittori, Gloria Cristalli, Neli Melman, Kyung-Sun Park, Xiao-duo Ji, Kenneth A. Jacobson

J Med Chem. Author manuscript; available in PMC 2022 Aug 10.

Published in final edited form as: J Med Chem. 1998 Aug 13; 41(17): 3174–3185. doi: 10.1021/jm980147p

PMCID:: PMC9364910

Abstract Article PDF–1.0M

Select item 91947167.

Structural Determinants of A₃ Adenosine Receptor Activation: Nucleoside Ligands at the Agonist/Antagonist Boundary

Zhan-Guo Gao, Soo-Kyung Kim, Thibaud Biadatti, Wangzhong Chen, Kyeong Lee, Dov Barak, Seong Gon Kim, Carl R. Johnson, Kenneth A. Jacobson

J Med Chem. Author manuscript; available in PMC 2022 Jun 14.

Published in final edited form as: J Med Chem. 2002 Sep 26; 45(20): 4471–4484. doi: 10.1021/jm020211+

PMCID:: PMC9194716

Abstract Article PDF–2.0M

Select item 84131948.

Characterization of dopamine D₂ receptor coupling to G proteins in postmortem brain of subjects with schizophrenia

Iker Egusquiza, Eva Munarriz-Cuezva, Rafael Segarra, Javier González-Maeso, Luis F. Callado, J. Javier Meana, Rebeca Diez-Alarcia

Pharmacol Rep. 2021; 73(4): 1136–1146. Published online 2021 Jul 1. doi: 10.1007/s43440-021-00305-4

PMCID:: PMC8413194

Abstract Article PDF–827K

Select item 80956109.

RESEARCH ARTICLE: Up‐regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

José L. Albasanz, Sandra Perez, Marta Barrachina, Isidro Ferrer, Mairena Martín

Brain Pathol. 2008 Apr; 18(2): 211–219. Published online 2008 Jan 31. doi: 10.1111/j.1750-3639.2007.00112.x

PMCID:: PMC8095610

Abstract Article PDF–465K

Select item 802677410.

Mu opioids induce biased signaling at the full-length seven transmembrane C-terminal splice variants of the mu opioid receptor gene, Oprm1

Ankita Narayan, Amanda Hunkele, Jin Xu, Daniel L. Bassoni, Gavril W. Pasternak, Ying-Xian Pan

Cell Mol Neurobiol. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Cell Mol Neurobiol. 2021 Jul; 41(5): 1059–1074. Published online 2020 Oct 8. doi: 10.1007/s10571-020-00973-5

Correction in:: Cell Mol Neurobiol. 2021 Jul; 41(5): 1075.

PMCID:: PMC8026774

Abstract Article PDF–1.0M

Select item 769821011.

A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes

Carina Höring, Ulla Seibel, Katharina Tropmann, Lukas Grätz, Denise Mönnich, Sebastian Pitzl, Günther Bernhardt, Steffen Pockes, Andrea Strasser

Int J Mol Sci. 2020 Nov; 21(22): 8440. Published online 2020 Nov 10. doi: 10.3390/ijms21228440

PMCID:: PMC7698210

Abstract Article PDF–1.6M

Select item 742949212.

Δ⁹‐Tetrahydrocannabinolic acid alleviates collagen‐induced arthritis: Role of PPARγ and CB₁ receptors

Belén Palomares, Martín Garrido‐Rodriguez, Claudia Gonzalo‐Consuegra, María Gómez‐Cañas, Suwipa Saen‐oon, Robert Soliva, Juan A. Collado, Javier Fernández‐Ruiz, Gaetano Morello, Marco A. Calzado, Giovanni Appendino, Eduardo Muñoz

Br J Pharmacol. 2020 Sep; 177(17): 4034–4054. Published online 2020 Jul 8. doi: 10.1111/bph.15155

PMCID:: PMC7429492

Abstract Article PDF–8.7M

Select item 695260013.

Probing thermostability of detergent-solubilized CB₂ receptor by parallel G protein–activation and ligand-binding assays

Ryan L. Beckner, Lioudmila Zoubak, Kirk G. Hines, Klaus Gawrisch, Alexei A. Yeliseev

J Biol Chem. 2020 Jan 3; 295(1): 181–190. Published online 2019 Nov 27. doi: 10.1074/jbc.RA119.010696

PMCID:: PMC6952600

Abstract Article PDF–1.7M

Select item 693568514.

Characterization of the various functional pathways elicited by synthetic agonists or antagonists at the melatonin MT₁ and MT₂ receptors

Céline Legros, Clémence Dupré, Chantal Brasseur, Anne Bonnaud, Olivier Bruno, Damien Valour, Preety Shabajee, Adeline Giganti, Olivier Nosjean, Terrence P. Kenakin, Jean A. Boutin

Pharmacol Res Perspect. 2020 Feb; 8(1): e00539. Published online 2019 Dec 29. doi: 10.1002/prp2.539

PMCID:: PMC6935685

Abstract Article PDF–3.3M

Select item 690160615.

A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

Travis W. Grim, Cullen L. Schmid, Edward L. Stahl, Fani Pantouli, Jo-Hao Ho, Agnes Acevedo-Canabal, Nicole M. Kennedy, Michael D. Cameron, Thomas D. Bannister, Laura M. Bohn

Neuropsychopharmacology. 2020 Jan; 45(2): 416–425. Published online 2019 Aug 23. doi: 10.1038/s41386-019-0491-8