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Select item 117263191.

Akt substrate of 160 kDa is essential for the calorie restriction-induced increase in insulin-stimulated glucose uptake by skeletal muscle of female rats

Amy Zheng, Haiyan Wang, Edward B. Arias, Gengfu Dong, Jiahui Zhao, Gregory D. Cartee

Appl Physiol Nutr Metab. Author manuscript; available in PMC 2025 Jan 13.

Published in final edited form as: Appl Physiol Nutr Metab. 2023 Mar 1; 48(3): 283–292. Published online 2023 Jan 12. doi: 10.1139/apnm-2022-0414

PMCID:: PMC11726319

Abstract Article PDF–1.3M

Select item 117262422.

MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma

Magretta Adiamah, Bethany Poole, Janet C Lindsey, Sarah Kohe, Alaide Morcavallo, Florence Burté, Rebecca M Hill, Helen Blair, Dean Thompson, Mankaran Singh, Shanel Swartz, Stephen Crosier, Tong Zhang, Oliver D K Maddocks, Andrew Peet, Louis Chesler, Ian Hickson, Ross J Maxwell, Steven C Clifford

Neuro Oncol. 2025 Jan; 27(1): 237–253. Published online 2024 Oct 8. doi: 10.1093/neuonc/noae179

PMCID:: PMC11726242

Abstract Article PDF–12M

Select item 117249813.

Two-component system GrpP/GrpQ promotes pathogenicity of uropathogenic Escherichia coli CFT073 by upregulating type 1 fimbria

Xueping Li, Yu Pang, Lingyan Jiang, Le Liu, Jiarui Zhou, Chen Jin, Qian Wang, Hongmin Sun, Qing Li, Zhen Chen, Jingliang Qin, Jianwei Mu, Bin Liu, Qiyue Zhang, Yutao Liu, Lu Feng, Lei Wang

Nat Commun. 2025; 16: 607. Published online 2025 Jan 11. doi: 10.1038/s41467-025-55982-z

PMCID:: PMC11724981

Abstract Article PDF–1.8M

Select item 117089114.

A tale of two serines: the effects of histone H2A mutations S122A and S129A on chromosome nondisjunction in Saccharomyces cerevisiae

Stanislav G Kozmin, Margaret Dominska, Robert J Kokoska, Thomas D Petes

Genetics. 2025 Jan; 229(1): 1–31. Published online 2024 Nov 18. doi: 10.1093/genetics/iyae194

PMCID:: PMC11708911

Abstract Article PDF–1.5M

Select item 117081975.

FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction

Zhukai Chen, Jiacheng Xu, Kang Fang, Hanyu Jiang, Zhuyun Leng, Hao Wu, Zehua Zhang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Shihan Zhang, Yuan Chu, Lechi Ye, Meidong Xu, Lingnan He, Tao Chen

Cell Commun Signal. 2025; 23: 13. Published online 2025 Jan 7. doi: 10.1186/s12964-024-02016-8

PMCID:: PMC11708197

Abstract Article PDF–13M

Select item 117050816.

Defining serine tRNA knockout as a strategy for effective repression of gene expression in organisms with a recoded genome

Peter J Voorhees, Xinyou Chang, Samuel K Lai

Nucleic Acids Res. 2025 Jan 13; 53(1): gkae1266. Published online 2025 Jan 7. doi: 10.1093/nar/gkae1266

PMCID:: PMC11705081

Abstract Article PDF–3.7M

Select item 117033937.

Structural comparison of substrate-binding pockets of serine β-lactamases in classes A, C, and D

Hyeonmin Lee, Hyunjae Park, Kiwoong Kwak, Chae-eun Lee, Jiwon Yun, Donghyun Lee, Jung Hun Lee, Sang Hee Lee, Lin-Woo Kang

J Enzyme Inhib Med Chem. 2025; 40(1): 2435365. Published online 2024 Dec 23. doi: 10.1080/14756366.2024.2435365

PMCID:: PMC11703393

Abstract Article PDF–8.3M

Select item 117033568.

A platform immunoassay for the quantification of biotherapeutics with glycine-serine linkers

Alexander Pöhler, Michael Antony, Janine Faigle, Gregor Jordan, Roland F Staack, Gregor P Lotz

Bioanalysis. 2024; 16(23-24): 1241–1248. Published online 2024 Dec 4. doi: 10.1080/17576180.2024.2435804

PMCID:: PMC11703356

Abstract Article PDF–2.2M

Select item 117018869.

AS160 expression, but not AS160 Serine-588, Threonine-642, and Serine-704 phosphorylation, is essential for elevated insulin-stimulated glucose uptake by skeletal muscle from female rats after acute exercise

Haiyan Wang, Amy Zheng, Edward B. Arias, Seong Eun Kwak, Xiufang Pan, Dongsheng Duan, Gregory D. Cartee

FASEB J. Author manuscript; available in PMC 2025 Jan 6.

Published in final edited form as: FASEB J. 2023 Jul; 37(7): e23021. doi: 10.1096/fj.202300282RR

PMCID:: PMC11701886

Abstract Article PDF–1.4M

Select item 1169398010.

AST‐001 versus placebo for social communication in children with autism spectrum disorder: A randomized clinical trial

Hyo‐Won Kim, Ji‐Hoon Kim, Un Sun Chung, Johanna Inhyang Kim, Se‐hoon Shim, Tae Won Park, Moon‐Soo Lee, Jun‐Won Hwang, Eun‐Jin Park, Su‐Kyeong Hwang, Yoo‐Sook Joung

Psychiatry Clin Neurosci. 2025 Jan; 79(1): 21–28. Published online 2024 Oct 18. doi: 10.1111/pcn.13757

PMCID:: PMC11693980

Abstract Article PDF–392K

Select item 1168466711.

PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period

Jonathan M. Philpott, Alfred M. Freeberg, Jiyoung Park, Kwangjun Lee, Clarisse G. Ricci, Sabrina R. Hunt, Rajesh Narasimamurthy, David H. Segal, Rafael Robles, Yao Cai, Sarvind Tripathi, J. Andrew McCammon, David M. Virshup, Joanna C. Chiu, Choogon Lee, Carrie L. Partch

Mol Cell. Author manuscript; available in PMC 2024 Dec 30.

Published in final edited form as: Mol Cell. 2023 May 18; 83(10): 1677–1692.e8. doi: 10.1016/j.molcel.2023.04.019

PMCID:: PMC11684667

Abstract Article PDF–2.7M

Select item 1167928312.

Exploring pH Dynamics in Amino Acid Solutions Under Low-Temperature Plasma Exposure

Cecilia Julieta Garcia Villavicencio, Beatriz de Campos Silva, Anesu Matara, Sylwia Ptasinska

Molecules. 2024 Dec; 29(24): 5889. Published online 2024 Dec 13. doi: 10.3390/molecules29245889

PMCID:: PMC11679283

Abstract Article PDF–2.1M

Select item 1167273113.

Metabolic engineering of the serine/glycine network as a means to improve the nitrogen content of crops

Ruben Casatejada‐Anchel, Alejandro Torres‐Moncho, Armand D. Anoman, Nagaveni Budhagatapalli, Ester Pérez‐Lorences, Andrea Alcántara‐Enguídanos, Sara Rosa‐Téllez, Leonardo Perez de Souza, Jochen Kumlehn, Alisdair R. Fernie, Jesús Muñoz‐Bertomeu, Roc Ros

Plant Biotechnol J. 2025 Jan; 23(1): 268–280. Published online 2024 Oct 25. doi: 10.1111/pbi.14495

PMCID:: PMC11672731

Abstract Article PDF–4.4M

Select item 1166917514.

Carbon Negative Synthesis of Amino Acids Using a Cell-Free-Based Biocatalyst

Shaafique Chowdhury, Ray Westenberg, Kimberly Wennerholm, Ryan A.L. Cardiff, Alexander S. Beliaev, Vincent Noireaux, James M. Carothers, Pamela Peralta-Yahya

ACS Synth Biol. 2024 Dec 20; 13(12): 3961–3975. Published online 2024 Nov 21. doi: 10.1021/acssynbio.4c00359

PMCID:: PMC11669175

Abstract Article PDF–6.5M

Select item 1166889515.

Comprehensive analysis of peripheral blood free amino acids in MASLD: the impact of glycine-serine-threonine metabolism

Masaaki Mino, Eiji Kakazu, Akitoshi Sano, Mio Tsuruoka, Hiroko Matsubara, Keisuke Kakisaka, Takayuki Kogure, Katsunori Sekine, Yoshihiko Aoki, Masatoshi Imamura, Michitaka Matsuda, Taiji Yamazoe, Taizo Mori, Sachiyo Yoshio, Jun Inoue, Atsushi Masamune, Tatsuya Kanto

Amino Acids. 2025; 57(1): 3. Published online 2024 Dec 24. doi: 10.1007/s00726-024-03433-2

PMCID:: PMC11668895

Abstract Article PDF–5.9M

Select item 1165824816.

Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions

Huijuan Wang, Mengzhen Fan, Sichang Liu, Mengjiao Qu, Xin Hou, Junqing Hou, Yanxin Xu, Xiaodi Shang, Chen Liu, Mingxia He, Jianzheng Gao, Jingying Chen, Xia Li

BMC Cancer. 2024; 24: 1515. Published online 2024 Dec 18. doi: 10.1186/s12885-024-13304-4

PMCID:: PMC11658248

Abstract Article PDF–7.2M

Select item 1164990317.

Determinants of chemoselectivity in ubiquitination by the J2 family of ubiquitin-conjugating enzymes

Anuruti Swarnkar, Florian Leidner, Ashok K Rout, Sofia Ainatzi, Claudia C Schmidt, Stefan Becker, Henning Urlaub, Christian Griesinger, Helmut Grubmüller, Alexander Stein

EMBO J. 2024 Dec; 43(24): 6705–6739. Published online 2024 Nov 12. doi: 10.1038/s44318-024-00301-3