PMC Links for Protein (Select 1008806548) - PMC

Select item 57801131.

INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program

Francesca Pirini, Sebastian Rodriguez-Torres, Bola Grace Ayandibu, María Orera-Clemente, Alberto Gonzalez-De La Vega, Fahcina Lawson, Roland J. Thorpe Jr, David Sidransky, Rafael Guerrero-Preston

Mol Med Rep. 2018 Jan; 17(1): 1699–1709. Published online 2017 Nov 14. doi: 10.3892/mmr.2017.8039

PMCID:: PMC5780113

Abstract Article PDF–1022K

Select item 54541172.

Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver

Seonghwan Hwang, Andrew D. Nguyen, Youngah Jo, Luke J. Engelking, James Brugarolas, Russell A. DeBose-Boyd

J Biol Chem. 2017 Jun 2; 292(22): 9382–9393. Published online 2017 Apr 17. doi: 10.1074/jbc.M117.788562

PMCID:: PMC5454117

Abstract Article PDF–586K

Select item 14056243.

Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines

Joon No Lee, Yi Gong, Xiangyu Zhang, Jin Ye

Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13): 4958–4963. Published online 2006 Mar 20. doi: 10.1073/pnas.0600422103

PMCID:: PMC1405624

Abstract Article PDF–1.4M

Select item 1522624.

Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis

Daisuke Yabe, Ryutaro Komuro, Guosheng Liang, Joseph L. Goldstein, Michael S. Brown

Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6): 3155–3160. Published online 2003 Mar 6. doi: 10.1073/pnas.0130116100

PMCID:: PMC152262

Abstract Article PDF–256K

Select item 1392025.

Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols

Daisuke Yabe, Zong-Ping Xia, Christopher M. Adams, Robert B. Rawson

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16672–16677. Published online 2002 Dec 13. doi: 10.1073/pnas.262669399

PMCID:: PMC139202

Abstract Article PDF–441K

Select item 1305326.

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Daisuke Yabe, Michael S. Brown, Joseph L. Goldstein

Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 12753–12758. Published online 2002 Sep 19. doi: 10.1073/pnas.162488899

PMCID:: PMC130532

Abstract Article PDF–296K

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