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Select item 45106531.

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

Yue Zhou, Naoki Yamada, Tomohiro Tanaka, Takashi Hori, Satoru Yokoyama, Yoshihiro Hayakawa, Seiji Yano, Junya Fukuoka, Keiichi Koizumi, Ikuo Saiki, Hiroaki Sakurai

Nat Commun. 2015; 6: 7679. Published online 2015 Jul 9. doi: 10.1038/ncomms8679

PMCID:: PMC4510653

Abstract Article PDF–2.1M

Select item 36184562.

RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation

Philippe P. Roux, David Shahbazian, Hieu Vu, Marina K. Holz, Michael S. Cohen, Jack Taunton, Nahum Sonenberg, John Blenis

J Biol Chem. Author manuscript; available in PMC 2013 Apr 6.

Published in final edited form as: J Biol Chem. 2007 May 11; 282(19): 14056–14064. Published online 2007 Mar 14. doi: 10.1074/jbc.M700906200

PMCID:: PMC3618456

Abstract Article PDF–2.2M

Select item 30395703.

Initial characterization of the human central proteome

Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge

BMC Syst Biol. 2011; 5: 17. Published online 2011 Jan 26. doi: 10.1186/1752-0509-5-17

PMCID:: PMC3039570

Abstract Article PDF–2.3M

Select item 27127194.

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal, Michael R. Stratton

Nature. Author manuscript; available in PMC 2009 Jul 20.

Published in final edited form as: Nature. 2007 Mar 8; 446(7132): 153–158. doi: 10.1038/nature05610

PMCID:: PMC2712719

Abstract Article PDF–867K

Select item 27091995.

Large-scale Proteomics Analysis of the Human Kinome

Felix S. Oppermann, Florian Gnad, Jesper V. Olsen, Renate Hornberger, Zoltán Greff, György Kéri, Matthias Mann, Henrik Daub

Mol Cell Proteomics. 2009 Jul; 8(7): 1751–1764. Published online 2009 Apr 15. doi: 10.1074/mcp.M800588-MCP200

PMCID:: PMC2709199

Abstract Article PDF–993K

Select item 25048356.

A quantitative atlas of mitotic phosphorylation

Noah Dephoure, Chunshui Zhou, Judit Villén, Sean A. Beausoleil, Corey E. Bakalarski, Stephen J. Elledge, Steven P. Gygi

Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31): 10762–10767. Published online 2008 Jul 31. doi: 10.1073/pnas.0805139105

PMCID:: PMC2504835

Abstract Article PDF–1.0M

Select item 22228277.

Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors

Mari Ikuta, Maria Kornienko, Noel Byrne, John C. Reid, Shinji Mizuarai, Hidehito Kotani, Sanjeev K. Munshi

Protein Sci. 2007 Dec; 16(12): 2626–2635. doi: 10.1110/ps.073123707

PMCID:: PMC2222827

Abstract Article PDF–534K

Select item 15008468.

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

David Shahbazian, Philippe P Roux, Virginie Mieulet, Michael S Cohen, Brian Raught, Jack Taunton, John W B Hershey, John Blenis, Mario Pende, Nahum Sonenberg

EMBO J. 2006 Jun 21; 25(12): 2781–2791. Published online 2006 Jun 8. doi: 10.1038/sj.emboj.7601166

PMCID:: PMC1500846

Abstract Article PDF–368K

Select item 13607249.

Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation

Andrew D. Wingate, David G. Campbell, Mark Peggie, J. Simon C. Arthur

Biochem J. 2006 Feb 1; 393(Pt 3): 715–724. Prepublished online 2005 Oct 13. Published online 2006 Jan 13. doi: 10.1042/BJ20050967

PMCID:: PMC1360724

Abstract Article PDF–701K

Select item 117077510.

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

M Deak, A D Clifton, L M Lucocq, D R Alessi

EMBO J. 1998 Aug 3; 17(15): 4426–4441. doi: 10.1093/emboj/17.15.4426

PMCID:: PMC1170775

Summary PDF–1.5M

Select item 52892811.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 51878412.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

Philippe P. Roux, Bryan A. Ballif, Rana Anjum, Steven P. Gygi, John Blenis

Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37): 13489–13494. Published online 2004 Sep 1. doi: 10.1073/pnas.0405659101

PMCID:: PMC518784

Abstract Article PDF–556K

Select item 16220613.

Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity

Philippe P. Roux, Stephanie A. Richards, John Blenis

Mol Cell Biol. 2003 Jul; 23(14): 4796–4804. doi: 10.1128/MCB.23.14.4796-4804.2003

PMCID:: PMC162206

Abstract Article PDF–501K

Select item 691675514.

Analog-sensitive cell line identifies cellular substrates of CDK9

Tim-Michael Decker, Ignasi Forné, Tobias Straub, Hesham Elsaman, Guoli Ma, Nilay Shah, Axel Imhof, Dirk Eick

Oncotarget. 2019 Dec 10; 10(65): 6934–6943. Published online 2019 Dec 10. doi: 10.18632/oncotarget.27334

PMCID:: PMC6916755

Abstract Article PDF–1.7M

Select item 671364315.

Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma

Piao Guo, Yuchao He, Lu Chen, Lisha Qi, Dongming Liu, Ziye Chen, Manyu Xiao, Liwei Chen, Yi Luo, Ning Zhang, Hua Guo

Cancer Biol Med. 2019 May; 16(2): 377–390. doi: 10.20892/j.issn.2095-3941.2018.0386

PMCID:: PMC6713643

Abstract Article PDF–16M

Select item 644192616.

The Ibr‐7 derivative of ibrutinib exhibits enhanced cytotoxicity against non‐small cell lung cancer cells via targeting of mTORC1/S6 signaling

Bo Zhang, Linling Wang, Qi Zhang, Youyou Yan, Hong Jiang, Runlei Hu, Xinglu Zhou, Xingguo Liu, Jianguo Feng, Nengming Lin

Mol Oncol. 2019 Apr; 13(4): 946–958. Published online 2019 Feb 22. doi: 10.1002/1878-0261.12454

PMCID:: PMC6441926

Abstract Article PDF–1.1M

Select item 627287017.

Proteomic Profiling of Iron Overload-Induced Human Hepatic Cells Reveals Activation of TLR2-Mediated Inflammatory Response

Xiang Li, Shiwei Li, Mize Lu, Guohua Yang, Yunfeng Shen, Xin Zhou

Molecules. 2016 Mar; 21(3): 322. Published online 2016 Mar 17. doi: 10.3390/molecules21030322

PMCID:: PMC6272870

Abstract Article PDF–1.9M

Select item 598116618.

14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling

Yunfeng Chen, Zaverio M. Ruggeri, Xiaoping Du

Blood. 2018 May 31; 131(22): 2436–2448. Prepublished online 2018 Apr 5. doi: 10.1182/blood-2017-09-742650

PMCID:: PMC5981166

Abstract Article

Select item 586096119.

Application of large scale aptamer-based proteomic profiling to “planned” myocardial infarctions

Jaison Jacob, Debby Ngo, Nancy Finkel, Rebecca Pitts, Scott Gleim, Mark D. Benson, Michelle J. Keyes, Laurie A. Farrell, Thomas Morgan, Lori L. Jennings, Robert E. Gerszten

Circulation. Author manuscript; available in PMC 2019 Mar 20.

Published in final edited form as: Circulation. 2018 Mar 20; 137(12): 1270–1277. Published online 2017 Dec 8. doi: 10.1161/CIRCULATIONAHA.117.029443

PMCID:: PMC5860961

Abstract Article PDF–204K

Select item 561710420.

Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

Xiao-Kang Lun, Vito RT Zanotelli, James D Wade, Denis Schapiro, Marco Tognetti, Nadine Dobberstein, Bernd Bodenmiller

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 27.

Published in final edited form as: Nat Biotechnol. 2017 Feb; 35(2): 164–172. Published online 2017 Jan 16. doi: 10.1038/nbt.3770

PMCID:: PMC5617104

Abstract Article PDF–2.1M

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