PMC Links for Protein (Select 296439317) - PMC

Select item 67264701.

Quantifying the contribution of recessive coding variation to developmental disorders

Hilary C. Martin, Wendy D. Jones, Rebecca McIntyre, Gabriela Sanchez-Andrade, Mark Sanderson, James D. Stephenson, Carla P. Jones, Juliet Handsaker, Giuseppe Gallone, Michaela Bruntraeger, Jeremy F. McRae, Elena Prigmore, Patrick Short, Mari Niemi, Joanna Kaplanis, Elizabeth J. Radford, Nadia Akawi, Meena Balasubramanian, John Dean, Rachel Horton, Alice Hulbert, Diana S. Johnson, Katie Johnson, Dhavendra Kumar, Sally Ann Lynch, Sarju G. Mehta, Jenny Morton, Michael J. Parker, Miranda Splitt, Peter D Turnpenny, Pradeep C. Vasudevan, Michael Wright, Andrew Bassett, Sebastian S. Gerety, Caroline F. Wright, David R. FitzPatrick, Helen V. Firth, Matthew E. Hurles, Jeffrey C. Barrett

Science. Author manuscript; available in PMC 2019 Sep 4.

Published in final edited form as: Science. 2018 Dec 7; 362(6419): 1161–1164. Published online 2018 Nov 8. doi: 10.1126/science.aar6731

PMCID:: PMC6726470

Abstract Article PDF–1.3M

Select item 57780852.

Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders

Víctor Faundes, William G. Newman, Laura Bernardini, Natalie Canham, Jill Clayton-Smith, Bruno Dallapiccola, Sally J. Davies, Michelle K. Demos, Amy Goldman, Harinder Gill, Rachel Horton, Bronwyn Kerr, Dhavendra Kumar, Anna Lehman, Shane McKee, Jenny Morton, Michael J. Parker, Julia Rankin, Lisa Robertson, I. Karen Temple, Clinical Assessment of the Utility of Sequencing and Evaluation as a Service (CAUSES) Study, The Deciphering Developmental Disorders (DDD) Study, Siddharth Banka

Am J Hum Genet. 2018 Jan 4; 102(1): 175–187. Published online 2017 Dec 21. doi: 10.1016/j.ajhg.2017.11.013

PMCID:: PMC5778085

Abstract Article PDF–2.3M

Select item 47427343.

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases

John R. Horton, Amanda Engstrom, Elizabeth L. Zoeller, Xu Liu, John R. Shanks, Xing Zhang, Margaret A. Johns, Paula M. Vertino, Haian Fu, Xiaodong Cheng

J Biol Chem. 2016 Feb 5; 291(6): 2631–2646. Published online 2015 Dec 8. doi: 10.1074/jbc.M115.698449

PMCID:: PMC4742734

Abstract Article PDF–5.2M

Select item 44244104.

System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability

Zhenyu Xiao, Jer-Gung Chang, Ivo A. Hendriks, Jón Otti Sigurðsson, Jesper V. Olsen, Alfred C.O. Vertegaal

Mol Cell Proteomics. 2015 May; 14(5): 1419–1434. doi: 10.1074/mcp.O114.044792

PMCID:: PMC4424410

Abstract Article PDF–2.2M

Select item 42590105.

Uncovering Global SUMOylation Signaling Networks in a Site-Specific Manner

Ivo A. Hendriks, Rochelle C.J. D’Souza, Bing Yang, Matty Verlaan-de Vries, Matthias Mann, Alfred C.O. Vertegaal

Nat Struct Mol Biol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Nat Struct Mol Biol. 2014 Oct; 21(10): 927–936. Published online 2014 Sep 14. doi: 10.1038/nsmb.2890

PMCID:: PMC4259010

Abstract Article PDF–2.9M

Select item 42254856.

The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B

Yan Zhang, Huirong Yang, Xue Guo, Naiyan Rong, Yujiao Song, Youwei Xu, Wenxian Lan, Xu Zhang, Maili Liu, Yanhui Xu, Chunyang Cao

Protein Cell. 2014 Nov; 5(11): 837–850. Published online 2014 Jun 22. doi: 10.1007/s13238-014-0078-4

PMCID:: PMC4225485

Abstract Article PDF–2.9M

Select item 25048357.

A quantitative atlas of mitotic phosphorylation

Noah Dephoure, Chunshui Zhou, Judit Villén, Sean A. Beausoleil, Corey E. Bakalarski, Stephen J. Elledge, Steven P. Gygi

Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31): 10762–10767. Published online 2008 Jul 31. doi: 10.1073/pnas.0805139105

PMCID:: PMC2504835

Abstract Article PDF–1.0M

Select item 18208968.

The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

Julie Secombe, Ling Li, Leni Carlos, Robert N. Eisenman

Genes Dev. 2007 Mar 1; 21(5): 537–551. doi: 10.1101/gad.1523007

PMCID:: PMC1820896

Abstract Article PDF–989K

Select item 60485979.

The Characteristics of a PHD Finger Subtype

Daniel Boamah, Tao Lin, Franchesca A. Poppinga, Shraddha Basu, Shahariar Rahman, Francisca Essel, Suvobrata Chakravarty

Biochemistry. Author manuscript; available in PMC 2019 Feb 6.

Published in final edited form as: Biochemistry. 2018 Feb 6; 57(5): 525–539. Published online 2018 Jan 5. doi: 10.1021/acs.biochem.7b00705

PMCID:: PMC6048597

Abstract Article PDF–2.8M

Select item 581057010.

Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases

Zhenlin Yang, Qi Qiu, Wei Chen, Bei Jia, Xiaomei Chen, Hongmiao Hu, Kaixuan He, Xian Deng, Sisi Li, W. Andy Tao, Xiaofeng Cao, Jiamu Du

Plant Cell. 2018 Jan; 30(1): 167–177. Published online 2017 Dec 12. doi: 10.1105/tpc.17.00666

PMCID:: PMC5810570

Abstract Article PDF–1.8M

Select item 568414011.

JMJD8 is a novel endoplasmic reticulum protein with a JmjC domain

Kok Siong Yeo, Ming Cheang Tan, Yat-Yuen Lim, Chee-Kwee Ea

Sci Rep. 2017; 7: 15407. Published online 2017 Nov 13. doi: 10.1038/s41598-017-15676-z

PMCID:: PMC5684140

Abstract Article PDF–3.7M

Select item 536173712.

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Anthony Tumber, Andrea Nuzzi, Edward S. Hookway, Stephanie B. Hatch, Srikannathasan Velupillai, Catrine Johansson, Akane Kawamura, Pavel Savitsky, Clarence Yapp, Aleksandra Szykowska, Na Wu, Chas Bountra, Claire Strain-Damerell, Nicola A. Burgess-Brown, Gian Filippo Ruda, Oleg Fedorov, Shonagh Munro, Katherine S. England, Radoslaw P. Nowak, Christopher J. Schofield, Nicholas B. La Thangue, Charlotte Pawlyn, Faith Davies, Gareth Morgan, Nick Athanasou, Susanne Müller, Udo Oppermann, Paul E. Brennan

Cell Chem Biol. 2017 Mar 16; 24(3): 371–380. Published online 2017 Mar 16. doi: 10.1016/j.chembiol.2017.02.006

PMCID:: PMC5361737

Abstract Article PDF–2.6M

Select item 533339513.

Assessing histone demethylase inhibitors in cells: lessons learned

Stephanie B. Hatch, Clarence Yapp, Raquel C. Montenegro, Pavel Savitsky, Vicki Gamble, Anthony Tumber, Gian Filippo Ruda, Vassilios Bavetsias, Oleg Fedorov, Butrus Atrash, Florence Raynaud, Rachel Lanigan, LeAnne Carmichael, Kathy Tomlin, Rosemary Burke, Susan M. Westaway, Jack A. Brown, Rab K. Prinjha, Elisabeth D. Martinez, Udo Oppermann, Christopher J. Schofield, Chas Bountra, Akane Kawamura, Julian Blagg, Paul E. Brennan, Olivia Rossanese, Susanne Müller

Epigenetics Chromatin. 2017; 10: 9. Published online 2017 Mar 1. doi: 10.1186/s13072-017-0116-6

PMCID:: PMC5333395

Abstract Article PDF–8.4M

Select item 477032414.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Vassilios Bavetsias, Rachel M. Lanigan, Gian Filippo Ruda, Butrus Atrash, Mark G. McLaughlin, Anthony Tumber, N. Yi Mok, Yann-Vaï Le Bihan, Sally Dempster, Katherine J. Boxall, Fiona Jeganathan, Stephanie B. Hatch, Pavel Savitsky, Srikannathasan Velupillai, Tobias Krojer, Katherine S. England, Jimmy Sejberg, Ching Thai, Adam Donovan, Akos Pal, Giuseppe Scozzafava, James M. Bennett, Akane Kawamura, Catrine Johansson, Aleksandra Szykowska, Carina Gileadi, Nicola A. Burgess-Brown, Frank von Delft, Udo Oppermann, Zoe Walters, Janet Shipley, Florence I. Raynaud, Susan M. Westaway, Rab K. Prinjha, Oleg Fedorov, Rosemary Burke, Christopher J. Schofield, Isaac M. Westwood, Chas Bountra, Susanne Müller, Rob L. M. van Montfort, Paul E. Brennan, Julian Blagg

J Med Chem. 2016 Feb 25; 59(4): 1388–1409. Published online 2016 Jan 7. doi: 10.1021/acs.jmedchem.5b01635

PMCID:: PMC4770324

Abstract Article PDF–2.3M

Select item 468109715.

A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases

Dante Rotili, Mikael Altun, Akane Kawamura, Alexander Wolf, Roman Fischer, Ivanhoe K. H. Leung, Mukram M. Mackeen, Ya-min Tian, Peter J. Ratcliffe, Antonello Mai, Benedikt M. Kessler, Christopher J. Schofield

Chem Biol. Author manuscript; available in PMC 2015 Dec 16.

Published in final edited form as: Chem Biol. 2011 May 27; 18(5): 642–654. doi: 10.1016/j.chembiol.2011.03.007