PMC Links for Protein (Select 317373385) - PMC

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Select item 51595031.

Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation

Xin Wang, Yingying Jia, Cong Fei, Xiaomin Song, Lin Li

J Biol Chem. 2016 Dec 16; 291(51): 26427–26434. Published online 2016 Nov 7. doi: 10.1074/jbc.M116.744607

PMCID:: PMC5159503

Abstract Article PDF–1.1M

Select item 50140862.

Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf

Matthias Zebisch, Verity A. Jackson, Yuguang Zhao, E. Yvonne Jones

Structure. 2016 Sep 6; 24(9): 1599–1605. doi: 10.1016/j.str.2016.06.020

PMCID:: PMC5014086

Abstract Article PDF–2.1M

Select item 45969133.

Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia

Maarten P.G. Massink, Marijn A. Créton, Francesca Spanevello, Willem M.M. Fennis, Marco S. Cune, Sanne M.C. Savelberg, Isaäc J. Nijman, Madelon M. Maurice, Marie-José H. van den Boogaard, Gijs van Haaften

Am J Hum Genet. 2015 Oct 1; 97(4): 621–626. Published online 2015 Sep 17. doi: 10.1016/j.ajhg.2015.08.014

PMCID:: PMC4596913

Abstract Article PDF–722K

Select item 42563444.

Structural Insights into the C1q Domain of Caprin-2 in Canonical Wnt Signaling

Haofei Miao, Yingying Jia, Sichun Xie, Xin Wang, Jianfei Zhao, Youjun Chu, Zhilei Zhou, Zhubing Shi, Xiaomin Song, Lin Li

J Biol Chem. 2014 Dec 5; 289(49): 34104–34113. Published online 2014 Oct 20. doi: 10.1074/jbc.M114.591636

PMCID:: PMC4256344

Abstract Article PDF–2.1M

Select item 37455355.

Rare nonconservative LRP6 mutations are associated with metabolic syndrome

Rajvir Singh, Emily Smith, Mohsen Fathzadeh, Wenzhong Liu, Gwang-Woong Go, Lakshman Subrahmanyan, Saeed Faramarzi, William McKenna, Arya Mani

Hum Mutat. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Hum Mutat. 2013 Sep; 34(9): 1221–1225. Published online 2013 Jun 18. doi: 10.1002/humu.22360

PMCID:: PMC3745535

Abstract Article PDF–1.3M

Select item 33647536.

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

Yong Jiang, Xi He, Philip H Howe

EMBO J. 2012 May 16; 31(10): 2336–2349. Published online 2012 Apr 10. doi: 10.1038/emboj.2012.83

PMCID:: PMC3364753

Abstract Article PDF–1.5M

Select item 32158557.

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6

Victoria E. Ahn, Matthew Ling-Hon Chu, Hee-Jung Choi, Denise Tran, Arie Abo, William I. Weis

Dev Cell. Author manuscript; available in PMC 2012 Nov 15.

Published in final edited form as: Dev Cell. 2011 Nov 15; 21(5): 862–873. Published online 2011 Oct 13. doi: 10.1016/j.devcel.2011.09.003

PMCID:: PMC3215855

Abstract Article PDF–2.3M

Select item 31333788.

Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation

Juan Liang, Yu Fu, Cristina-Maria Cruciat, Shunji Jia, Ying Wang, Zhen Tong, Qinghua Tao, Dierk Ingelfinger, Michael Boutros, Anming Meng, Christof Niehrs, Wei Wu

Mol Cell Biol. 2011 Jul; 31(13): 2577–2590. doi: 10.1128/MCB.05103-11

PMCID:: PMC3133378

Abstract Article PDF–2.3M

Select item 29452229.

LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

Arya Mani, Jayaram Radhakrishnan, He Wang, Alaleh Mani, Mohammad-Ali Mani, Carol Nelson-Williams, Khary S Carew, Shrikant Mane, Hossein Najmabadi, Dan Wu, Richard P. Lifton

Science. Author manuscript; available in PMC 2010 Sep 24.

Published in final edited form as: Science. 2007 Mar 2; 315(5816): 1278–1282. doi: 10.1126/science.1136370

Correction in:: volume 341 on page 959

PMCID:: PMC2945222

Abstract Article PDF–1.7M

Select item 283833610.

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

Eric Bourhis, Christine Tam, Yvonne Franke, J. Fernando Bazan, James Ernst, Jiyoung Hwang, Mike Costa, Andrea G. Cochran, Rami N. Hannoush

J Biol Chem. 2010 Mar 19; 285(12): 9172–9179. Published online 2010 Jan 21. doi: 10.1074/jbc.M109.092130

PMCID:: PMC2838336

Abstract Article PDF–1.4M

Select item 278736511.

G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway

Minyong Chen, Melanie Philipp, Jiangbo Wang, Richard T. Premont, Tiffany R. Garrison, Marc G. Caron, Robert J. Lefkowitz, Wei Chen

J Biol Chem. 2009 Dec 11; 284(50): 35040–35048. Published online 2009 Oct 2. doi: 10.1074/jbc.M109.047456

PMCID:: PMC2787365

Abstract Article PDF–1.8M

Select item 265414512.

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

Geng Wu, He Huang, Jose Garcia Abreu, Xi He

PLoS One. 2009; 4(3): e4926. Published online 2009 Mar 18. doi: 10.1371/journal.pone.0004926

PMCID:: PMC2654145

Abstract Article PDF–398K

Select item 260331313.

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

Shunfu Piao, Sun-Hye Lee, Hyunjoon Kim, Soohwan Yum, Jennifer L. Stamos, Yongbin Xu, Su-Jin Lee, Jaewon Lee, Sangtaek Oh, Jin-Kwan Han, Bum-Joon Park, William I. Weis, Nam-Chul Ha

PLoS One. 2008; 3(12): e4046. Published online 2008 Dec 24. doi: 10.1371/journal.pone.0004046

PMCID:: PMC2603313

Abstract Article PDF–952K

Select item 252858114.

Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation

Yu Ding, Ying Xi, Ting Chen, Ji-yong Wang, Dong-lei Tao, Zhi-Li Wu, Yi-ping Li, Chen Li, Rong Zeng, Lin Li

J Cell Biol. 2008 Sep 8; 182(5): 865–872. doi: 10.1083/jcb.200803147

PMCID:: PMC2528581

Abstract Article PDF–1.7M

Select item 241429415.

Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6

Bryan T. MacDonald, Chika Yokota, Keiko Tamai, Xin Zeng, Xi He

J Biol Chem. 2008 Jun 6; 283(23): 16115–16123. doi: 10.1074/jbc.M800327200

PMCID:: PMC2414294

Abstract Article PDF–341K

Select item 229109616.

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

Laurence Abrami, Béatrice Kunz, Ioan Iacovache, F. Gisou van der Goot

Proc Natl Acad Sci U S A. 2008 Apr 8; 105(14): 5384–5389. Published online 2008 Mar 31. doi: 10.1073/pnas.0710389105

PMCID:: PMC2291096

Abstract Article PDF–1.0M

Select item 216890317.

Analysis of Endogenous LRP6 Function Reveals a Novel Feedback Mechanism by Which Wnt Negatively Regulates Its Receptor

Zahid Khan, Sapna Vijayakumar, Teresa Villanueva de la Torre, Sabrina Rotolo, Anna Bafico

Mol Cell Biol. 2007 Oct; 27(20): 7291–7301. Published online 2007 Aug 13. doi: 10.1128/MCB.00773-07

PMCID:: PMC2168903

Abstract Article PDF–476K

Select item 210041818.

A dual-kinase mechanism for Wnt coreceptor phosphorylation and activation

Xin Zeng, Keiko Tamai, Brad Doble, Shitao Li, He Huang, Raymond Habas, Heidi Okamura, Jim Woodgett, Xi He

Nature. Author manuscript; available in PMC 2007 Dec 3.

Published in final edited form as: Nature. 2005 Dec 8; 438(7069): 873–877. doi: 10.1038/nature04185

PMCID:: PMC2100418

Abstract Article PDF–1.0M

Select item 196548419.

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

Minke E. Binnerts, Kyung-Ah Kim, Jessica M. Bright, Sejal M. Patel, Karolyn Tran, Mei Zhou, John M. Leung, Yi Liu, Woodrow E. Lomas, III, Melissa Dixon, Sophie A. Hazell, Marie Wagle, Wen-Sheng Nie, Nenad Tomasevic, Jason Williams, Xiaoming Zhan, Michael D. Levy, Walter D. Funk, Arie Abo

Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37): 14700–14705. Published online 2007 Sep 5. doi: 10.1073/pnas.0702305104