PMC Links for Protein (Select 46577705) - PMC

Michael Downes, Mark A. Verdecia, A.J. Roecker, Robert Hughes, John B. Hogenesch, Heidi R. Kast-Woelbern, Marianne E. Bowman, Jean-Luc Ferrer, Andrew M. Anisfeld, Peter A. Edwards, John M. Rosenfeld, Jacqueline G.A. Alvarez, Joseph P. Noel, K.C Nicolaou, Ronald M. Evans

Mol Cell. Author manuscript; available in PMC 2018 Oct 10.

Published in final edited form as: Mol Cell. 2003 Apr; 11(4): 1079–1092. doi: 10.1016/s1097-2765(03)00104-7

PMCID:: PMC6179153

Abstract Article PDF–1.6M

Select item 47596304.

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

Natalia Gomez-Ospina, Carol J. Potter, Rui Xiao, Kandamurugu Manickam, Mi-Sun Kim, Kang Ho Kim, Benjamin L. Shneider, Jennifer L. Picarsic, Theodora A. Jacobson, Jing Zhang, Weimin He, Pengfei Liu, A. S. Knisely, Milton J. Finegold, Donna M. Muzny, Eric Boerwinkle, James R. Lupski, Sharon E. Plon, Richard A. Gibbs, Christine M. Eng, Yaping Yang, Gabriel C. Washington, Matthew H. Porteus, William E. Berquist, Neeraja Kambham, Ravinder J. Singh, Fan Xia, Gregory M. Enns, David D. Moore

Nat Commun. 2016; 7: 10713. Published online 2016 Feb 18. doi: 10.1038/ncomms10713

PMCID:: PMC4759630

Abstract Article PDF–1.1M

Select item 39200915.

Identification of Functionally Relevant Lysine Residues That Modulate Human Farnesoid X Receptor Activation

An-Qiang Sun, Yuhuan Luo, Donald S. Backos, Shuhua Xu, Natarajan Balasubramaniyan, Philip Reigan, Frederick J. Suchy

Mol Pharmacol. 2013 May; 83(5): 1078–1086. Published online 2013 May. doi: 10.1124/mol.113.084772

PMCID:: PMC3920091

Abstract Article PDF–1.3M

Select item 36504216.

SUMOylation of the Farnesoid X Receptor (FXR) Regulates the Expression of FXR Target Genes

Natarajan Balasubramaniyan, Yuhuan Luo, An-Qiang Sun, Frederick J. Suchy

J Biol Chem. 2013 May 10; 288(19): 13850–13862. Published online 2013 Apr 1. doi: 10.1074/jbc.M112.443937

PMCID:: PMC3650421

Abstract Article PDF–4.7M

Select item 33620727.

Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes

Natarajan Balasubramaniyan, Meena Ananthanarayanan, Frederick J. Suchy

Am J Physiol Gastrointest Liver Physiol. 2012 May 1; 302(9): G937–G947. Published online 2012 Feb 16. doi: 10.1152/ajpgi.00441.2011

PMCID:: PMC3362072

Abstract Article

Select item 31639488.

Farnesoid X receptor represses hepatic human APOA gene expression

Indumathi Chennamsetty, Thierry Claudel, Karam M. Kostner, Anna Baghdasaryan, Dagmar Kratky, Sanja Levak-Frank, Sasa Frank, Frank J. Gonzalez, Michael Trauner, Gert M. Kostner

J Clin Invest. 2011 Sep 1; 121(9): 3724–3734. Published online 2011 Aug 1. doi: 10.1172/JCI45277

PMCID:: PMC3163948

Abstract Article PDF–1.9M

Select item 30492269.

Deciphering the nuclear bile acid receptor FXR paradigm

Salvatore Modica, Raffaella M. Gadaleta, Antonio Moschetta

Nucl Recept Signal. 2010; 8: e005. Published online 2010 Nov 19. doi: 10.1621/nrs.08005

PMCID:: PMC3049226

Abstract Article PDF–2.9M

Select item 278669410.

Functional Specificities of Brm and Brg-1 Swi/Snf ATPases in the Feedback Regulation of Hepatic Bile Acid Biosynthesis

Ji Miao, Sungsoon Fang, Jiyoung Lee, Clay Comstock, Karen E. Knudsen, Jongsook Kim Kemper

Mol Cell Biol. 2009 Dec; 29(23): 6170–6181. Published online 2009 Oct 5. doi: 10.1128/MCB.00825-09

PMCID:: PMC2786694

Abstract Article PDF–2.7M

Select item 278507511.

FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states

Jongsook Kim Kemper, Zhen Xiao, Bhaskar Ponugoti, Ji Miao, Sungsoon Fang, Deepthi Kanamaluru, Stephanie Tsang, Shwu-Yuan Wu, Cheng-Ming Chiang, Timothy D. Veenstra

Cell Metab. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: Cell Metab. 2009 Nov; 10(5): 392–404. doi: 10.1016/j.cmet.2009.09.009

PMCID:: PMC2785075

Abstract Article PDF–2.4M

Select item 277489412.

The Membrane Protein, ATP8B1, Signals Through Protein Kinase C-Zeta to Activate the Farnesoid X Receptor

Tamara Frankenberg, Tamir Miloh, Frank Y. Chen, Meena Ananthanarayanan, An-Qiang Sun, Natarajan Balasubramaniyan, Irwin Arias, Kenneth D. R. Setchell, Frederick J. Suchy, Benjamin L. Shneider

Hepatology. Author manuscript; available in PMC 2009 Dec 1.

Published in final edited form as: Hepatology. 2008 Dec; 48(6): 1896–1905. doi: 10.1002/hep.22431

PMCID:: PMC2774894

Abstract Article PDF–1.0M

Select item 275489713.

ASCOM Controls Farnesoid X Receptor Transactivation through Its Associated Histone H3 Lysine 4 Methyltransferase Activity

Dae-Hwan Kim, Jeongkyung Lee, Bora Lee, Jae W. Lee

Mol Endocrinol. 2009 Oct; 23(10): 1556–1562. Published online 2009 Jun 25. doi: 10.1210/me.2009-0099

PMCID:: PMC2754897

Abstract Article

Select item 261445414.

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

Kwang-Hoon Song, Tiangang Li, Erika Owsley, Stephen Strom, John Y. L. Chiang

Hepatology. Author manuscript; available in PMC 2010 Jan 1.

Published in final edited form as: Hepatology. 2009 Jan; 49(1): 297–305. doi: 10.1002/hep.22627

PMCID:: PMC2614454

Abstract Article PDF–412K

Select item 229112215.

Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

Stephen M. Soisson, Gopalakrishnan Parthasarathy, Alan D. Adams, Soumya Sahoo, Ayesha Sitlani, Carl Sparrow, Jisong Cui, Joseph W. Becker

Proc Natl Acad Sci U S A. 2008 Apr 8; 105(14): 5337–5342. Published online 2008 Apr 7. doi: 10.1073/pnas.0710981105

PMCID:: PMC2291122

Abstract Article PDF–857K

Select item 200039716.

Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis

Sabyasachi Sanyal, Ann Båvner, Anna Haroniti, Lisa-Mari Nilsson, Thomas Lundåsen, Stefan Rehnmark, Michael Robin Witt, Curt Einarsson, Iannis Talianidis, Jan-åke Gustafsson, Eckardt Treuter

Proc Natl Acad Sci U S A. 2007 Oct 2; 104(40): 15665–15670. Published online 2007 Sep 25. doi: 10.1073/pnas.0706736104

PMCID:: PMC2000397

Abstract Article PDF–1.4M

Select item 113396717.

The nuclear bile acid receptor FXR is activated by PGC-1α in a ligand-dependent manner

Eiko Kanaya, Takuma Shiraki, Hisato Jingami

Biochem J. 2004 Sep 15; 382(Pt 3): 913–921. Prepublished online 2004 Jun 17. Published online 2004 Sep 7. doi: 10.1042/BJ20040432

PMCID:: PMC1133967

Abstract Article PDF–604K

Select item 52892818.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 19613119.

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

Jason A. Holt, Guizhen Luo, Andrew N. Billin, John Bisi, Y. Yvette McNeill, Karen F. Kozarsky, Mary Donahee, Da Yuan Wang, Traci A. Mansfield, Steven A. Kliewer, Bryan Goodwin, Stacey A. Jones

Genes Dev. 2003 Jul 1; 17(13): 1581–1591. doi: 10.1101/gad.1083503

PMCID:: PMC196131

Abstract Article PDF–439K

Select item 15092920.

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

Thierry Claudel, Ekkehard Sturm, Hélène Duez, Inés Pineda Torra, Audrey Sirvent, Vladimir Kosykh, Jean-Charles Fruchart, Jean Dallongeville, Dean W. Hum, Folkert Kuipers, Bart Staels

J Clin Invest. 2002 Apr 1; 109(7): 961–971. doi: 10.1172/JCI14505

PMCID:: PMC150929

Abstract Article PDF–2.0M

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