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Select item 62198431.

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Herschel S Dhekne, Izumi Yanatori, Rachel C Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R Alessi, Suzanne R Pfeffer

eLife. 2018; 7: e40202. Published online 2018 Nov 6. doi: 10.7554/eLife.40202

PMCID:: PMC6219843

Abstract Article PDF–5.5M

Select item 56959102.

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

Martin Steger, Federico Diez, Herschel S Dhekne, Pawel Lis, Raja S Nirujogi, Ozge Karayel, Francesca Tonelli, Terina N Martinez, Esben Lorentzen, Suzanne R Pfeffer, Dario R Alessi, Matthias Mann

eLife. 2017; 6: e31012. Published online 2017 Nov 10. doi: 10.7554/eLife.31012

PMCID:: PMC5695910

Abstract Article PDF–2.7M

Select item 50264843.

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication

Amrita Rai, Anastasia Oprisko, Jeremy Campos, Yangxue Fu, Timon Friese, Aymelt Itzen, Roger S Goody, Emerich Mihai Gazdag, Matthias P Müller

eLife. 2016; 5: e18675. Published online 2016 Aug 23. doi: 10.7554/eLife.18675

PMCID:: PMC5026484

Abstract Article PDF–4.2M

Select item 49105334.

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

Chantal Sellier, Maria‐Letizia Campanari, Camille Julie Corbier, Angeline Gaucherot, Isabelle Kolb‐Cheynel, Mustapha Oulad‐Abdelghani, Frank Ruffenach, Adeline Page, Sorana Ciura, Edor Kabashi, Nicolas Charlet‐Berguerand

EMBO J. 2016 Jun 15; 35(12): 1276–1297. Published online 2016 Apr 21. doi: 10.15252/embj.201593350

PMCID:: PMC4910533

Abstract Article PDF–1.5M

Select item 47691695.

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Martin Steger, Francesca Tonelli, Genta Ito, Paul Davies, Matthias Trost, Melanie Vetter, Stefanie Wachter, Esben Lorentzen, Graham Duddy, Stephen Wilson, Marco AS Baptista, Brian K Fiske, Matthew J Fell, John A Morrow, Alastair D Reith, Dario R Alessi, Matthias Mann

eLife. 2016; 5: e12813. Published online 2016 Jan 29. doi: 10.7554/eLife.12813

PMCID:: PMC4769169

Abstract Article PDF–4.1M

Select item 36716126.

Pitchfork Regulates Primary Cilia Dizsassembly and Left-Right Asymmetry

Doris Kinzel, Karsten Boldt, Erica E. Davis, Ingo Burtscher, Dietrich Trümbach, Bill Diplas, Tania Attié-Bitach, Wolfgang Wurst, Nicholas Katsanis, Marius Ueffing, Heiko Lickert

Dev Cell. Author manuscript; available in PMC 2013 Jun 4.

Published in final edited form as: Dev Cell. 2010 Jul 20; 19(1): 66–77. doi: 10.1016/j.devcel.2010.06.005

PMCID:: PMC3671612

Abstract Article PDF–4.7M

Select item 33921097.

OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome

Na Luo, Callah C. West, Carlos A. Murga-Zamalloa, Lou Sun, Ryan M. Anderson, Clark D. Wells, Robert N. Weinreb, Jeffrey B. Travers, Hemant Khanna, Yang Sun

Hum Mol Genet. 2012 Aug 1; 21(15): 3333–3344. Published online 2012 Apr 27. doi: 10.1093/hmg/dds163

PMCID:: PMC3392109

Abstract Article PDF–469K

Select item 32715818.

A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo

Yanqun Chen, Bin Wu, Liangliang Xu, Huapeng Li, Jianhong Xia, Wenguang Yin, Zhuo Li, Dawei Shi, Song Li, Shuo Lin, Xiaodong Shu, Duanqing Pei

Cell Res. 2012 Feb; 22(2): 333–345. Published online 2011 Aug 16. doi: 10.1038/cr.2011.134

PMCID:: PMC3271581

Abstract Article PDF–1.5M

Select item 31022829.

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

Xiaomin Hou, Nina Hagemann, Stefan Schoebel, Wulf Blankenfeldt, Roger S Goody, Kai S Erdmann, Aymelt Itzen

EMBO J. 2011 Apr 20; 30(8): 1659–1670. Published online 2011 Mar 4. doi: 10.1038/emboj.2011.60

PMCID:: PMC3102282

Abstract Article PDF–1.1M

Select item 304113010.

Rab GTPase–Myo5B complexes control membrane recycling and epithelial polarization

Joseph T. Roland, David M. Bryant, Anirban Datta, Aymelt Itzen, Keith E. Mostov, James R. Goldenring

Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7): 2789–2794. Published online 2011 Jan 31. doi: 10.1073/pnas.1010754108

PMCID:: PMC3041130

Abstract Article PDF–940K

Select item 303957011.

Initial characterization of the human central proteome

Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge

BMC Syst Biol. 2011; 5: 17. Published online 2011 Jan 26. doi: 10.1186/1752-0509-5-17

PMCID:: PMC3039570

Abstract Article PDF–2.3M

Select item 297567512.

A molecular network for de novo generation of the apical surface and lumen

David M. Bryant, Anirban Datta, Alejo E. Rodriguez-Fraticelli, Johan Peränen, Fernando Martin-Belmonte, Keith E. Mostov

Nat Cell Biol. Author manuscript; available in PMC 2010 Nov 8.

Published in final edited form as: Nat Cell Biol. 2010 Nov; 12(11): 1035–1045. Published online 2010 Oct 3. doi: 10.1038/ncb2106

PMCID:: PMC2975675

Abstract Article PDF–3.2M

Select item 279329413.

MICAL-L1 Links EHD1 to Tubular Recycling Endosomes and Regulates Receptor Recycling

Mahak Sharma, Sai Srinivas Panapakkam Giridharan, Juliati Rahajeng, Naava Naslavsky, Steve Caplan

Mol Biol Cell. 2009 Dec 15; 20(24): 5181–5194. doi: 10.1091/mbc.E09-06-0535

PMCID:: PMC2793294

Abstract Article PDF–3.7M

Select item 250483514.

A quantitative atlas of mitotic phosphorylation

Noah Dephoure, Chunshui Zhou, Judit Villén, Sean A. Beausoleil, Corey E. Bakalarski, Stephen J. Elledge, Steven P. Gygi

Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31): 10762–10767. Published online 2008 Jul 31. doi: 10.1073/pnas.0805139105

PMCID:: PMC2504835

Abstract Article PDF–1.0M

Select item 217188215.

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

Daniela A. Sahlender, Rhys C. Roberts, Susan D. Arden, Giulietta Spudich, Marcus J. Taylor, J. Paul Luzio, John Kendrick-Jones, Folma Buss

J Cell Biol. 2005 Apr 25; 169(2): 285–295. doi: 10.1083/jcb.200501162

PMCID:: PMC2171882

Abstract Article PDF–3.0M

Select item 211989316.

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

J Cell Biol. 1994 Jan 1; 124(1): 101–115. doi: 10.1083/jcb.124.1.101

PMCID:: PMC2119893

Summary PDF–6.6M

Select item 52892817.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 12488818.

A Rab8-specific GDP/GTP Exchange Factor Is Involved in Actin Remodeling and Polarized Membrane Transport

Katarina Hattula, Johanna Furuhjelm, Airi Arffman, Johan Peränen

Mol Biol Cell. 2002 Sep; 13(9): 3268–3280. doi: 10.1091/mbc.E02-03-0143

PMCID:: PMC124888

Abstract Article PDF–1.0M

Select item 675956619.

Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis

Gunner P. Johnston, Birgit Bradel-Tretheway, Paul D. Piehowski, Heather M. Brewer, Bom Nae Rin Lee, Nicholas T. Usher, J. Lizbeth Reyes Zamora, Victoria Ortega, Erik M. Contreras, Jeremy R. Teuton, Jason P. Wendler, Keesha M. Matz, Joshua N. Adkins, Hector C. Aguilar

mSystems. 2019 Sep-Oct; 4(5): e00194-19. Published online 2019 Sep 24. doi: 10.1128/mSystems.00194-19

PMCID:: PMC6759566

Abstract Article PDF–2.3M

Select item 673742320.

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Pedro L. Moura, Maria A. Lizarralde Iragorri, Olivier Français, Bruno Le Pioufle, Johannes G. G. Dobbe, Geert J. Streekstra, Wassim El Nemer, Ashley M. Toye, Timothy J. Satchwell

Blood Adv. 2019 Sep 10; 3(17): 2653–2663. Published online 2019 Sep 10. doi: 10.1182/bloodadvances.2019000545