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Items: 1 to 20 of 23

1.
Human CYP3A4 and Murine Cyp3A11 Are Regulated by Equol and Genistein via the Pregnane X Receptor in a Species-Specific Manner
Yilan Li, Jennifer S. Ross-Viola, Neil F. Shay, David D. Moore, Marie-Louise Ricketts
J Nutr. 2009 May; 139(5): 898–904. doi: 10.3945/jn.108.103572
PMCID:
PMC2714390
AbstractArticlePDF–770K
2.
Structural Basis of Human PXR Activation by the Hops Constituent Colupulone
Denise G. Teotico, Jason J. Bischof, Li Peng, Steven A. Kliewer, Matthew R. Redinbo
Mol Pharmacol. Author manuscript; available in PMC 2008 Dec 1.
Published in final edited form as: Mol Pharmacol. 2008 Dec; 74(6): 1512–1520. Published online 2008 Sep 2. doi: 10.1124/mol.108.050732
PMCID:
PMC2584763
AbstractArticlePDF–3.0M
3.
Crystal Structure of the PXR-T1317 Complex Provides a Scaffold to Examine the Potential for Receptor Antagonism
Yu Xue, Esther Chao, William J. Zuercher, Timothy M. Willson, Jon L. Collins, Matthew R. Redinbo
Bioorg Med Chem. Author manuscript; available in PMC 2008 Mar 1.
Published in final edited form as: Bioorg Med Chem. 2007 Mar 1; 15(5): 2156–2166. Published online 2006 Dec 20. doi: 10.1016/j.bmc.2006.12.026
PMCID:
PMC1839856
AbstractArticlePDF–1.0M
4.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
5.
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
J M Lehmann, D D McKee, M A Watson, T M Willson, J T Moore, S A Kliewer
J Clin Invest. 1998 Sep 1; 102(5): 1016–1023. doi: 10.1172/JCI3703
PMCID:
PMC508967
SummaryPDF–332K
6.
SXR, a novel steroid and xenobioticsensing nuclear receptor
Bruce Blumberg, Walid Sabbagh, Jr., Henry Juguilon, Jack Bolado, Jr., Casey M. van Meter, Estelita S. Ong, Ronald M. Evans
Genes Dev. 1998 Oct 15; 12(20): 3195–3205. doi: 10.1101/gad.12.20.3195
PMCID:
PMC317212
AbstractArticlePDF–1.6M
7.
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
Göran Bertilsson, Jessica Heidrich, Kristian Svensson, Michael Åsman, Lena Jendeberg, Mona Sydow-Bäckman, Rolf Ohlsson, Hans Postlind, Patrik Blomquist, Anders Berkenstam
Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21): 12208–12213. doi: 10.1073/pnas.95.21.12208
PMCID:
PMC22810
AbstractArticlePDF–324K
8.
Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia
Bingxuan Niu, Hui Zhang, Chunyan Li, Fulin Yan, Yu Song, Guangfan Hai, Yunjuan Jiao, Yansheng Feng
Drug Des Devel Ther. 2019; 13: 3009–3019. Published online 2019 Sep 5. doi: 10.2147/DDDT.S207955
PMCID:
PMC6733351
AbstractArticlePDF–2.7M
9.
Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis
Yueying Tao, Kunming Tian, Ji Chen, Danfeng Tan, Yan Liu, Yongai Xiong, Zehui Chen, Yingbiao Tian
Evid Based Complement Alternat Med. 2019; 2019: 2630357. Published online 2019 Jul 3. doi: 10.1155/2019/2630357
PMCID:
PMC6636523
AbstractArticlePDF–10M
10.
The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology
Guilin Ren, Yu Zhong, Gang Ke, Xiaoli Liu, Huiting Li, Xiaofang Li, Qin Zheng, Ming Yang
Evid Based Complement Alternat Med. 2019; 2019: 9241403. Published online 2019 Jun 4. doi: 10.1155/2019/9241403
PMCID:
PMC6582871
AbstractArticlePDF–1.5M
11.
Sequence Variations in pxr (nr1i2) From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function
Roger Lille-Langøy, Odd André Karlsen, Line Merethe Myklebust, Jared V Goldstone, Astrid Mork-Jansson, Rune Male, Bruce Blumberg, John J Stegeman, Anders Goksøyr
Toxicol Sci. 2019 Mar; 168(1): 28–39. Published online 2018 Oct 29. doi: 10.1093/toxsci/kfy269
PMCID:
PMC6390661
AbstractArticlePDF–1.0M
12.
Drug–target–disease network analysis of gene–phenotype connectivity for genistein in ovarian cancer
Chen Zhang, Fan Yang, Suiqin Ni, Wenbing Teng, Yingxia Ning
Onco Targets Ther. 2018; 11: 8901–8908. Published online 2018 Dec 10. doi: 10.2147/OTT.S183302
PMCID:
PMC6292408
AbstractArticlePDF–2.7M
13.
System Pharmacology-Based Strategy to Decode the Synergistic Mechanism of Zhi-zhu Wan for Functional Dyspepsia
Chun Wang, Qing Ren, Xue-Tong Chen, Zhi-Qian Song, Zhang-Chi Ning, Jia-He Gan, Xin-Ling Ma, Dong-Rui Liang, Dao-Gang Guan, Zhen-Li Liu, Ai-Ping Lu
Front Pharmacol. 2018; 9: 841. Published online 2018 Aug 6. doi: 10.3389/fphar.2018.00841
PMCID:
PMC6087764
AbstractArticlePDF–4.7M
14.
GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula
Baixia Zhang, Shuaibing He, Chenyang Lv, Yanling Zhang, Yun Wang
Evid Based Complement Alternat Med. 2018; 2018: 6935350. Published online 2018 Mar 6. doi: 10.1155/2018/6935350
PMCID:
PMC5859853
AbstractArticlePDF–712K
15.
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Nuclear hormone receptors
Stephen PH Alexander, John A Cidlowski, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Br J Pharmacol. 2017 Dec; 174(Suppl Suppl 1): S208–S224. Published online 2017 Oct 21. doi: 10.1111/bph.13880
PMCID:
PMC5650662
AbstractArticlePDF–455K
16.
Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency
T Liu, T Oprea, O Ursu, C Hasselgren, RB Altman
Clin Transl Sci. 2016 Dec; 9(6): 311–320. Published online 2016 Oct 13. doi: 10.1111/cts.12422
PMCID:
PMC5161261
AbstractArticlePDF–319K
17.
Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing
Hansaim Lim, Aleksandar Poleksic, Yuan Yao, Hanghang Tong, Di He, Luke Zhuang, Patrick Meng, Lei Xie
PLoS Comput Biol. 2016 Oct; 12(10): e1005135. Published online 2016 Oct 7. doi: 10.1371/journal.pcbi.1005135
Correction in:
PLoS Comput Biol. 2017 Jan; 13(1): e1005312.
PMCID:
PMC5055357
AbstractArticlePDF–6.0M
18.
The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors
Stephen PH Alexander, John A Cidlowski, Eamonn Kelly, Neil Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Br J Pharmacol. 2015 Dec; 172(24): 5956–5978. Published online 2015 Dec 9. doi: 10.1111/bph.13352
PMCID:
PMC4718213
AbstractArticlePDF–537K
19.
Target network differences between western drugs and Chinese herbal ingredients in treating cardiovascular disease
Peng Fu, Linlin Yang, Yi Sun, Li Ye, Zhiwei Cao, Kailin Tang
BMC Bioinformatics. 2014; 15(Suppl 4): S3. Published online 2014 Mar 19. doi: 10.1186/1471-2105-15-S4-S3
PMCID:
PMC4095000
AbstractArticlePDF–4.6M
20.
Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor
Kuen-Bao Chen, Hsin-Yi Chen, Kuan-Chung Chen, Calvin Yu-Chian Chen
Biomed Res Int. 2014; 2014: 950191. Published online 2014 Jun 22. doi: 10.1155/2014/950191
PMCID:
PMC4090537
AbstractArticlePDF–17M

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