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Items: 1 to 20 of 59

1.
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
Sander Beel, Matthieu Moisse, Markus Damme, Louis De Muynck, Wim Robberecht, Ludo Van Den Bosch, Paul Saftig, Philip Van Damme
Hum Mol Genet. 2017 Aug 1; 26(15): 2850–2863. Published online 2017 Apr 26. doi: 10.1093/hmg/ddx162
PMCID:
PMC5886064
AbstractArticlePDF–1.6M
2.
The lysosomal protein cathepsin L is a progranulin protease
Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, Leonard Petrucelli
Mol Neurodegener. 2017; 12: 55. Published online 2017 Jul 25. doi: 10.1186/s13024-017-0196-6
PMCID:
PMC5526245
AbstractArticlePDF–2.4M
3.
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
Xiaolai Zhou, Lirong Sun, Oliver Bracko, Ji Whae Choi, Yan Jia, Alissa L. Nana, Owen Adam Brady, Jean C. Cruz Hernandez, Nozomi Nishimura, William W. Seeley, Fenghua Hu
Nat Commun. 2017; 8: 15277. Published online 2017 May 25. doi: 10.1038/ncomms15277
PMCID:
PMC5477518
AbstractArticlePDF–8.6M
4.
Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
Jinlong Jian, Qing-Yun Tian, Aubryanna Hettinghouse, Shuai Zhao, Helen Liu, Jianlu Wei, Gabriele Grunig, Wujuan Zhang, Kenneth D.R. Setchell, Ying Sun, Herman S. Overkleeft, Gerald L. Chan, Chuan-ju Liu
EBioMedicine. 2016 Nov; 13: 212–224. Published online 2016 Oct 24. doi: 10.1016/j.ebiom.2016.10.010
PMCID:
PMC5264254
AbstractArticlePDF–2.2M
5.
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin
Xiaolai Zhou, Lirong Sun, Francisco Bastos de Oliveira, Xiaoyang Qi, William J. Brown, Marcus B. Smolka, Ying Sun, Fenghua Hu
J Cell Biol. 2015 Sep 14; 210(6): 991–1002. doi: 10.1083/jcb.201502029
PMCID:
PMC4576858
AbstractArticlePDF–3.0M
6.
Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL)
Andrew D. Nguyen, Thi A. Nguyen, Basar Cenik, Gang Yu, Joachim Herz, Tobias C. Walther, W. Sean Davidson, Robert V. Farese, Jr.
J Biol Chem. 2013 Mar 22; 288(12): 8627–8635. Published online 2013 Jan 30. doi: 10.1074/jbc.M112.441949
PMCID:
PMC3605681
AbstractArticlePDF–1.5M
7.
Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage
Katherine R. Smith, John Damiano, Silvana Franceschetti, Stirling Carpenter, Laura Canafoglia, Michela Morbin, Giacomina Rossi, Davide Pareyson, Sara E. Mole, John F. Staropoli, Katherine B. Sims, Jada Lewis, Wen-Lang Lin, Dennis W. Dickson, Hans-Henrik Dahl, Melanie Bahlo, Samuel F. Berkovic
Am J Hum Genet. 2012 Jun 8; 90(6): 1102–1107. doi: 10.1016/j.ajhg.2012.04.021
PMCID:
PMC3370276
AbstractArticlePDF–425K
8.
Sortilin-Mediated Endocytosis Determines Levels of the Fronto-Temporal Dementia Protein, Progranulin
Fenghua Hu, Thihan Padukkavidana, Christian B. Vægter, Owen A. Brady, Yanqiu Zheng, Ian R. Mackenzie, Howard H. Feldman, Anders Nykjaer, Stephen M. Strittmatter
Neuron. Author manuscript; available in PMC 2011 Nov 18.
Published in final edited form as: Neuron. 2010 Nov 18; 68(4): 654–667. doi: 10.1016/j.neuron.2010.09.034
PMCID:
PMC2990962
AbstractArticlePDF–1.6M
9.
A Thorough Assessment of Benign Genetic Variability in GRN and MAPT
Rita J. Guerreiro, Nicole Washecka, John Hardy, Andrew Singleton
Hum Mutat. Author manuscript; available in PMC 2011 Feb 1.
Published in final edited form as: Hum Mutat. 2010 Feb; 31(2): E1126–E1140. doi: 10.1002/humu.21152
PMCID:
PMC2815037
AbstractArticlePDF–305K
10.
HDDD2 Is a Familial Frontotemporal Lobar Degeneration with Ubiquitin-Positive, Tau-Negative Inclusions Caused by a Missense Mutation in the Signal Peptide of Progranulin
Odity Mukherjee, Pau Pastor, Nigel J. Cairns, Sumi Chakraverty, John S. K. Kauwe, Shantia Shears, Maria I. Behrens, John Budde, Anthony L. Hinrichs, Joanne Norton, Denise Levitch, Lisa Taylor-Reinwald, Michael Gitcho, P.-H. Tu, Lea Tenenholz Grinberg, Rajka M. Liscic, Javier Armendariz, John C. Morris, Alison M. Goate
Ann Neurol. Author manuscript; available in PMC 2010 Jan 7.
Published in final edited form as: Ann Neurol. 2006 Sep; 60(3): 314–322. doi: 10.1002/ana.20963
PMCID:
PMC2803024
AbstractArticlePDF–3.7M
11.
Molecular Characterization of Novel Progranulin (GRN) Mutations in Frontotemporal Dementia
Odity Mukherjee, Jun Wang, Michael Gitcho, Sumi Chakraverty, Lisa Taylor-Reinwald, Shantia Shears, John S.K. Kauwe, Joanne Norton, Denise Levitch, Eileen H. Bigio, Kimmo J. Hatanpaa, Charles L. White, John C. Morris, Nigel J. Cairns, Alison Goate
Hum Mutat. Author manuscript; available in PMC 2009 Oct 5.
Published in final edited form as: Hum Mutat. 2008 Apr; 29(4): 512–521. doi: 10.1002/humu.20681
PMCID:
PMC2756561
AbstractArticlePDF–2.1M
12.
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
Philip Van Damme, Annelies Van Hoecke, Diether Lambrechts, Peter Vanacker, Elke Bogaert, John van Swieten, Peter Carmeliet, Ludo Van Den Bosch, Wim Robberecht
J Cell Biol. 2008 Apr 7; 181(1): 37–41. doi: 10.1083/jcb.200712039
PMCID:
PMC2287280
AbstractArticlePDF–1.1M
13.
Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
Dmitri Tolkatchev, Suneil Malik, Anna Vinogradova, Ping Wang, Zhigang Chen, Ping Xu, Hugh P.J. Bennett, Andrew Bateman, Feng Ni
Protein Sci. 2008 Apr; 17(4): 711–724. doi: 10.1110/ps.073295308
PMCID:
PMC2271164
AbstractArticlePDF–677K
14.
Characterisation of UGP and its relationship with beta-core fragment.
A. Kardana, K. D. Bagshawe, B. Coles, D. Read, M. Taylor
Br J Cancer. 1993 Apr; 67(4): 686–692. doi: 10.1038/bjc.1993.127
PMCID:
PMC1968365
SummaryPage BrowsePDF–1.1M
15.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K
16.
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
V Bhandari, R G Palfree, A Bateman
Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5): 1715–1719. doi: 10.1073/pnas.89.5.1715
PMCID:
PMC48523
SummaryPage BrowsePDF–1.1M
17.
Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1
Serge Nataf, Marine Guillen, Laurent Pays
Front Immunol. 2019; 10: 2704. Published online 2019 Nov 25. doi: 10.3389/fimmu.2019.02704
PMCID:
PMC6886494
AbstractArticlePDF–1.6M
18.
iTRAQ-based proteomics analysis of aqueous humor in patients with dry age-related macular degeneration
Si-Chang Qu, Ding Xu, Ting-Ting Li, Jing-Fa Zhang, Fang Liu
Int J Ophthalmol. 2019; 12(11): 1758–1766. Published online 2019 Nov 18. doi: 10.18240/ijo.2019.11.15
PMCID:
PMC6848880
AbstractArticlePDF–1.8M
19.
Glucose Restriction Plus Refeeding in Vitro Induce Changes of the Human Adipocyte Secretome with an Impact on Complement Factors and Cathepsins
Qi Qiao, Freek G. Bouwman, Marleen A. van Baak, Johan Renes, Edwin C.M. Mariman
Int J Mol Sci. 2019 Aug; 20(16): 4055. Published online 2019 Aug 20. doi: 10.3390/ijms20164055
PMCID:
PMC6719948
AbstractArticlePDF–1.1M
20.
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response
Victoria J. Butler, Fuying Gao, Christian I. Corrales, Wilian A. Cortopassi, Benjamin Caballero, Mihir Vohra, Kaveh Ashrafi, Ana Maria Cuervo, Matthew P. Jacobson, Giovanni Coppola, Aimee W. Kao
PLoS Genet. 2019 Aug; 15(8): e1008295. Published online 2019 Aug 9. doi: 10.1371/journal.pgen.1008295
PMCID:
PMC6703691
AbstractArticlePDF–3.9M

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