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    Efna2 ephrin A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84358, updated on 9-Dec-2024

    Summary

    Official Symbol
    Efna2provided by RGD
    Official Full Name
    ephrin A2provided by RGD
    Primary source
    RGD:620389
    See related
    EnsemblRapid:ENSRNOG00000016203 AllianceGenome:RGD:620389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ephrin receptor binding activity. Involved in axon guidance and olfactory bulb development. Located in neuromuscular junction and perikaryon. Orthologous to human EFNA2 (ephrin A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 12.0), Thymus (RPKM 7.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Efna2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10167091..10177719, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9515635..9528071, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12382636..12393266, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PWWP domain containing 3A, DNA repair factor Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene family with sequence similarity 174 member C Neighboring gene cold inducible RNA binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ephrin receptor binding  
    enables ephrin receptor binding  
    enables ephrin receptor binding PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in axon guidance PubMed 
    involved_in bone remodeling  
    involved_in bone remodeling  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway PubMed 
    involved_in inner ear morphogenesis PubMed 
    involved_in olfactory bulb development PubMed 
    involved_in osteoclast differentiation  
    involved_in osteoclast differentiation  
    Component Evidence Code Pubs
    located_in neuromuscular junction PubMed 
    located_in perikaryon PubMed 
    is_active_in plasma membrane  
    located_in side of membrane  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168670.1NP_001162141.1  ephrin-A2 precursor

      See identical proteins and their annotated locations for NP_001162141.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F1MA19
      Related
      ENSRNOP00000021709.4, ENSRNOT00000021709.7
      Conserved Domains (1) summary
      cd10425
      Location:31167
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10167091..10177719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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