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nish-1 PX domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177981, updated on 9-Dec-2024

Summary

Official Symbol
nish-1
Official Full Name
PX domain-containing protein
Primary source
WormBase:WBGene00008750
Locus tag
CELE_F13E9.1
See related
AllianceGenome:WB:WBGene00008750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See nish-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (10864331..10873635)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Histidine--tRNA ligase Neighboring gene Pre-mRNA-splicing factor RBM22 Neighboring gene Transmembrane protein Neighboring gene Neuropeptide-Like Protein Neighboring gene FIP (Fungus-Induced Protein) Related

Interactions

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in cytoplasm  

General protein information

Preferred Names
PX domain-containing protein
NP_502016.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10864331..10873635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069615.6NP_502016.2  PX domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502016.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8F807
    Conserved Domains (3) summary
    COG4886
    Location:289423
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:291313
    LRR_RI; leucine-rich repeat [structural motif]
    cl02563
    Location:18137
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
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