U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Lox lysyl oxidase [ Mus musculus (house mouse) ]

    Gene ID: 16948, updated on 10-Dec-2024

    Summary

    Official Symbol
    Loxprovided by MGI
    Official Full Name
    lysyl oxidaseprovided by MGI
    Primary source
    MGI:MGI:96817
    See related
    Ensembl:ENSMUSG00000024529 AllianceGenome:MGI:96817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rrg; TSC-160
    Summary
    This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
    Expression
    Biased expression in limb E14.5 (RPKM 47.6), ovary adult (RPKM 19.3) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lox in Genome Data Viewer
    Location:
    18 D1; 18 28.22 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52649132..52662939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52516060..52529867, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ferritin mitochondrial Neighboring gene STARR-seq mESC enhancer starr_44601 Neighboring gene STARR-positive B cell enhancer ABC_E7585 Neighboring gene STARR-seq mESC enhancer starr_44602 Neighboring gene serum response factor binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_44604 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 41724

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding  
    enables collagen binding  
    enables copper ion binding  
    enables copper ion binding  
    enables molecular adaptor activity  
    enables molecular adaptor activity  
    enables protein binding PubMed 
    enables protein-lysine 6-oxidase activity  
    enables protein-lysine 6-oxidase activity PubMed 
    enables protein-lysine 6-oxidase activity  
    enables small molecule binding  
    Items 1 - 25 of 43
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA biosynthetic process PubMed 
    acts_upstream_of_or_within aorta development PubMed 
    acts_upstream_of_or_within ascending aorta development PubMed 
    acts_upstream_of_or_within blood vessel development PubMed 
    involved_in blood vessel morphogenesis PubMed 
    acts_upstream_of_or_within bone mineralization PubMed 
    acts_upstream_of_or_within cell chemotaxis PubMed 
    acts_upstream_of_or_within cell chemotaxis PubMed 
    acts_upstream_of_or_within cellular response to chemokine PubMed 
    involved_in collagen fibril organization  
    acts_upstream_of_or_within collagen fibril organization PubMed 
    involved_in collagen fibril organization  
    acts_upstream_of_or_within connective tissue development PubMed 
    acts_upstream_of_or_within descending aorta development PubMed 
    acts_upstream_of_or_within elastic fiber assembly PubMed 
    involved_in elastic fiber assembly  
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within muscle cell cellular homeostasis PubMed 
    acts_upstream_of_or_within muscle cell development PubMed 
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within osteoblast differentiation PubMed 
    involved_in peptidyl-lysine oxidation  
    involved_in peptidyl-lysine oxidation  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor-beta signaling pathway PubMed 
    acts_upstream_of_or_within protein oxidation PubMed 
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    acts_upstream_of_or_within regulation of bone development PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of megakaryocyte differentiation PubMed 
    acts_upstream_of_or_within regulation of platelet-derived growth factor receptor-beta signaling pathway PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of receptor binding PubMed 
    acts_upstream_of_or_within regulation of receptor binding PubMed 
    acts_upstream_of_or_within regulation of striated muscle tissue development PubMed 
    acts_upstream_of_or_within regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in response to hormone  
    involved_in response to steroid hormone  
    involved_in response to steroid hormone  
    involved_in response to xenobiotic stimulus  
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    part_of collagen trimer PubMed 
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in collagen-containing extracellular matrix  
    located_in extracellular matrix PubMed 
    located_in extracellular matrix  
    located_in extracellular region PubMed 
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    protein-lysine 6-oxidase
    Names
    ras excision protein
    NP_001273110.1
    NP_001273111.1
    NP_034858.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286181.1NP_001273110.1  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_001273110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161119, AK141995, AK164634, BB840428, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TLP7, Q3TP83, Q3TWI1, Q3TX90, Q3TXH3
      Conserved Domains (2) summary
      PHA03247
      Location:57159
      PHA03247; large tegument protein UL36; Provisional
      pfam01186
      Location:207408
      Lysyl_oxidase; Lysyl oxidase
    2. NM_001286182.1NP_001273111.1  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_001273111.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC109203, AK164634, BQ033730
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TLP7, Q3TP83, Q3TWI1, Q3TX90, Q3TXH3
      Related
      ENSMUSP00000129247.2, ENSMUST00000171470.8
      Conserved Domains (2) summary
      PHA03247
      Location:57159
      PHA03247; large tegument protein UL36; Provisional
      pfam01186
      Location:207408
      Lysyl_oxidase; Lysyl oxidase
    3. NM_010728.4NP_034858.2  protein-lysine 6-oxidase preproprotein

      See identical proteins and their annotated locations for NP_034858.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC109203, AC161119
      Consensus CDS
      CCDS50289.1
      UniProtKB/Swiss-Prot
      P28301
      UniProtKB/TrEMBL
      Q3TLP7, Q3TP83, Q3TWI1, Q3TX90, Q3TXH3
      Related
      ENSMUSP00000025409.8, ENSMUST00000025409.9
      Conserved Domains (2) summary
      PHA03247
      Location:57159
      PHA03247; large tegument protein UL36; Provisional
      pfam01186
      Location:207408
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      52649132..52662939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.