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Ntn4 netrin 4 [ Mus musculus (house mouse) ]

Gene ID: 57764, updated on 9-Dec-2024

Summary

Official Symbol
Ntn4provided by MGI
Official Full Name
netrin 4provided by MGI
Primary source
MGI:MGI:1888978
See related
Ensembl:ENSMUSG00000020019 AllianceGenome:MGI:1888978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables laminin-1 binding activity. Acts upstream of or within neuron remodeling and regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling. Located in basement membrane. Is expressed in several structures, including alimentary system; cardiovascular system; connective tissue; genitourinary system; and nervous system. Orthologous to human NTN4 (netrin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in lung adult (RPKM 32.3), kidney adult (RPKM 17.5) and 20 other tissues See more
Orthologs
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Genomic context

See Ntn4 in Genome Data Viewer
Location:
10 C2; 10 48.59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93476911..93581834)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93641049..93745972)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8360 Neighboring gene STARR-seq mESC enhancer starr_27586 Neighboring gene coiled-coil domain containing 38 Neighboring gene STARR-positive B cell enhancer ABC_E6903 Neighboring gene RIKEN cDNA 4933408J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6904 Neighboring gene STARR-positive B cell enhancer ABC_E9800 Neighboring gene small nuclear ribonucleoprotein polypeptide F Neighboring gene STARR-seq mESC enhancer starr_27587 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene predicted gene 15915 Neighboring gene STARR-seq mESC enhancer starr_27589 Neighboring gene STARR-seq mESC enhancer starr_27590 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 26239

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables laminin-1 binding PubMed 
enables protein binding PubMed 
Component Evidence Code Pubs
located_in basement membrane PubMed 
located_in basement membrane PubMed 
located_in extracellular region  
part_of laminin complex  
located_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021320.3NP_067295.2  netrin-4 precursor

    See identical proteins and their annotated locations for NP_067295.2

    Status: VALIDATED

    Source sequence(s)
    AC151976, BB609851, BC119182, CF537120, CJ068258, CX205916
    Consensus CDS
    CCDS24128.1
    UniProtKB/Swiss-Prot
    E9QMT3, Q9JI33
    UniProtKB/TrEMBL
    Q0VEM1
    Related
    ENSMUSP00000020204.5, ENSMUST00000020204.5
    Conserved Domains (4) summary
    cd00055
    Location:261320
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03578
    Location:517626
    NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...
    pfam00053
    Location:395449
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:43260
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93476911..93581834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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