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Prss59 serine protease 59 [ Mus musculus (house mouse) ]

Gene ID: 73481, updated on 9-Dec-2024

Summary

Official Symbol
Prss59provided by MGI
Official Full Name
serine protease 59provided by MGI
Primary source
MGI:MGI:1920731
See related
Ensembl:ENSMUSG00000029883 AllianceGenome:MGI:1920731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tryx5; 1700074P13Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Located in Golgi apparatus. Orthologous to human PRSS59P (serine protease 59, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis adult (RPKM 86.3) See more
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Genomic context

See Prss59 in Genome Data Viewer
Location:
6 B1; 6 18.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40897371..40917975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40920437..40941041, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15690 Neighboring gene serine protease 58 Neighboring gene T cell receptor beta, variable 1 Neighboring gene RIKEN cDNA 1810009J06 gene Neighboring gene T cell receptor beta chain Neighboring gene trypsinogen pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (1) 

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in protein maturation  
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
is_active_in extracellular space  
is_active_in secretory granule  

General protein information

Preferred Names
trypsin X5
Names
protease, serine 59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_006980.1 

    Range
    29643..49763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361930.1NP_001348859.1  trypsin X5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161768, BC061035
    Consensus CDS
    CCDS20041.1
    UniProtKB/TrEMBL
    Q9D9G7
    Related
    ENSMUSP00000112987.2, ENSMUST00000122181.8
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_028550.4NP_082826.1  trypsin X5 precursor

    See identical proteins and their annotated locations for NP_082826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC161768, AK030264, BC061035
    Consensus CDS
    CCDS20041.1
    UniProtKB/TrEMBL
    Q9D9G7
    Related
    ENSMUSP00000031935.4, ENSMUST00000031935.10
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    40897371..40917975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506693.4XP_006506756.1  trypsin X5 isoform X2

    See identical proteins and their annotated locations for XP_006506756.1

    Conserved Domains (1) summary
    cl21584
    Location:36243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_030255627.1XP_030111487.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_030255628.1XP_030111488.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. XM_017321780.2XP_017177269.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. XM_017321779.2XP_017177268.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  6. XM_017321778.2XP_017177267.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  7. XM_030255629.1XP_030111489.1  trypsin X5 isoform X1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  8. XM_030255633.1XP_030111493.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  9. XM_030255630.1XP_030111490.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  10. XM_030255632.1XP_030111492.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  11. XM_030255631.1XP_030111491.1  trypsin X5 isoform X2

    Conserved Domains (1) summary
    cl21584
    Location:36243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  12. XM_011241489.4XP_011239791.1  trypsin X5 isoform X2

    See identical proteins and their annotated locations for XP_011239791.1

    Conserved Domains (1) summary
    cl21584
    Location:36243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  13. XM_011241488.3XP_011239790.1  trypsin X5 isoform X1

    See identical proteins and their annotated locations for XP_011239790.1

    UniProtKB/TrEMBL
    Q9D9G7
    Conserved Domains (1) summary
    cl21584
    Location:37244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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