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Pfn4 profilin family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 382562, updated on 9-Dec-2024

Summary

Official Symbol
Pfn4provided by MGI
Official Full Name
profilin family, member 4provided by MGI
Primary source
MGI:MGI:1920121
See related
Ensembl:ENSMUSG00000020639 AllianceGenome:MGI:1920121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900024P18Rik
Summary
Predicted to enable actin monomer binding activity. Involved in acrosome assembly; manchette assembly; and sperm flagellum assembly. Predicted to be located in cytoplasm. Predicted to be active in cell cortex. Is expressed in brain; ileum; and male reproductive gland or organ. Orthologous to human PFN4 (profilin family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 34.5), cortex adult (RPKM 2.0) and 2 other tissues See more
Orthologs
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Genomic context

See Pfn4 in Genome Data Viewer
Location:
12 A1.1; 12 2.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4819010..4828813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4769015..4778813)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228, member B Neighboring gene predicted gene, 23676 Neighboring gene predicted gene, 22003 Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene quinone oxidoreductase PIG3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (2) 

General gene information

Clone Names

  • 2900024P18Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding  
enables actin monomer binding  
enables lipid binding  
Process Evidence Code Pubs
involved_in acrosome assembly PubMed 
involved_in flagellated sperm motility PubMed 
involved_in manchette assembly PubMed 
involved_in sequestering of actin monomers  
involved_in sperm flagellum assembly PubMed 
involved_in spermatogenesis PubMed 
Component Evidence Code Pubs
is_active_in cell cortex  
located_in cytoplasm  

General protein information

Preferred Names
profilin-4
Names
profilin IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361147.1NP_001348076.1  profilin-4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein
    Source sequence(s)
    AY495949, BC094614, BI135172, CT025683
    Consensus CDS
    CCDS25790.1
    UniProtKB/Swiss-Prot
    Q6JEK6, Q9D6I3
    UniProtKB/TrEMBL
    A0A1W2P6U9
    Related
    ENSMUSP00000136765.2, ENSMUST00000178879.3
    Conserved Domains (1) summary
    pfam00235
    Location:14126
    Profilin
  2. NM_028376.4NP_082652.1  profilin-4

    See identical proteins and their annotated locations for NP_082652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC094614, BI135172, CT025683
    Consensus CDS
    CCDS25790.1
    UniProtKB/Swiss-Prot
    Q6JEK6, Q9D6I3
    UniProtKB/TrEMBL
    A0A1W2P6U9
    Related
    ENSMUSP00000020967.5, ENSMUST00000020967.11
    Conserved Domains (1) summary
    pfam00235
    Location:14126
    Profilin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    4819010..4828813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515140.4XP_006515203.1  profilin-4 isoform X1

    See identical proteins and their annotated locations for XP_006515203.1

    UniProtKB/Swiss-Prot
    Q6JEK6, Q9D6I3
    UniProtKB/TrEMBL
    A0A1W2P6U9
    Conserved Domains (1) summary
    pfam00235
    Location:14126
    Profilin
  2. XM_006515138.3XP_006515201.1  profilin-4 isoform X1

    See identical proteins and their annotated locations for XP_006515201.1

    UniProtKB/Swiss-Prot
    Q6JEK6, Q9D6I3
    UniProtKB/TrEMBL
    A0A1W2P6U9
    Conserved Domains (1) summary
    pfam00235
    Location:14126
    Profilin
  3. XM_006515141.4XP_006515204.1  profilin-4 isoform X2

    Conserved Domains (1) summary
    pfam00235
    Location:30123
    Profilin
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