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HSP90AA1 heat shock protein 90 alpha family class A member 1 [ Homo sapiens (human) ]

Gene ID: 3320, updated on 10-Dec-2024

Summary

Official Symbol
HSP90AA1provided by HGNC
Official Full Name
heat shock protein 90 alpha family class A member 1provided by HGNC
Primary source
HGNC:HGNC:5253
See related
Ensembl:ENSG00000080824 MIM:140571; AllianceGenome:HGNC:5253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
Summary
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in brain (RPKM 360.6), testis (RPKM 312.5) and 25 other tissues See more
Orthologs
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Genomic context

See HSP90AA1 in Genome Data Viewer
Location:
14q32.31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102080742..102139749, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96316329..96375332, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102547079..102606086, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene uncharacterized LOC107984661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102515797-102516781 Neighboring gene Sharpr-MPRA regulatory region 9666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102522673-102523378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102523379-102524082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102530418-102531305 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102550057-102551256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6107 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6110 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102605474-102605669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102622168-102623084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102623085-102624001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102625184-102625684 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:102638165-102639150 Neighboring gene WD repeat domain 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102650679-102651180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102651181-102651680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6111 Neighboring gene uncharacterized LOC105370677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MOK protein kinase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
Nef nef Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression PubMed
Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat Hyperthermia (39.5C) increases expression of HSP90 protein in CD4+ T cells, which enhances HIV-1 Tat-mediated transactivation of the LTR. Hyperthermia also increases single-cycle HIV-1 infection PubMed
tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
tat Hsp90 chaperone activity is required for HIV-1 Tat transport through the endosome membrane PubMed
tat Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat PubMed
tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
Vif vif HIV-1 Vif interacts with HSP90AA1; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1) at amino acid residues 473-474 and 491-492 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ31884

Gene Ontology Provided by GOA

Items 1 - 25 of 33
Function Evidence Code Pubs
enables ATP binding  
enables ATP binding PubMed 
enables ATP hydrolysis activity  
enables ATP hydrolysis activity PubMed 
enables ATP hydrolysis activity  
enables ATP-dependent protein folding chaperone  
enables CTP binding  
enables DNA polymerase binding PubMed 
enables GTP binding  
enables GTPase binding PubMed 
enables MHC class II protein complex binding PubMed 
enables RNA binding PubMed 
enables Rho GDP-dissociation inhibitor binding  
enables TPR domain binding PubMed 
enables TPR domain binding PubMed 
enables UTP binding  
enables dATP binding  
enables disordered domain specific binding PubMed 
enables histone deacetylase binding PubMed 
enables identical protein binding PubMed 
enables identical protein binding PubMed 
enables mRNA binding  
enables nitric-oxide synthase regulator activity PubMed 
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
enables protein phosphatase binding  
enables protein tyrosine kinase binding PubMed 
enables scaffold protein binding PubMed 
enables sulfonylurea receptor binding  
enables tau protein binding PubMed 
enables transmembrane transporter binding  
enables ubiquitin protein ligase binding PubMed 
enables unfolded protein binding  
Items 1 - 25 of 33
Items 1 - 25 of 41
Process Evidence Code Pubs
involved_in activation of innate immune response PubMed 
involved_in cardiac muscle cell apoptotic process  
involved_in cellular response to heat  
involved_in cellular response to virus PubMed 
involved_in chaperone-mediated autophagy PubMed 
involved_in chaperone-mediated protein complex assembly PubMed 
involved_in mitochondrial transport PubMed 
involved_in neurofibrillary tangle assembly PubMed 
involved_in neuron migration  
involved_in positive regulation of cardiac muscle contraction  
involved_in positive regulation of cell size  
involved_in positive regulation of defense response to virus by host PubMed 
involved_in positive regulation of interferon-beta production PubMed 
involved_in positive regulation of lamellipodium assembly  
involved_in positive regulation of nitric oxide biosynthetic process  
involved_in positive regulation of protein catabolic process PubMed 
involved_in positive regulation of protein import into nucleus  
involved_in positive regulation of protein polymerization PubMed 
involved_in positive regulation of telomere maintenance via telomerase PubMed 
involved_in protein folding  
involved_in protein insertion into mitochondrial outer membrane PubMed 
involved_in protein refolding PubMed 
involved_in protein stabilization  
involved_in protein stabilization PubMed 
involved_in protein unfolding PubMed 
involved_in regulation of apoptotic process PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
involved_in regulation of protein localization  
involved_in regulation of protein ubiquitination PubMed 
involved_in regulation of protein-containing complex assembly PubMed 
involved_in response to antibiotic  
involved_in response to cocaine  
involved_in response to cold  
involved_in response to estrogen  
involved_in response to heat  
involved_in response to salt stress  
involved_in response to unfolded protein PubMed 
involved_in response to xenobiotic stimulus  
involved_in skeletal muscle contraction  
involved_in telomerase holoenzyme complex assembly PubMed 
acts_upstream_of_positive_effect telomere maintenance via telomerase PubMed 
Items 1 - 25 of 41
Items 1 - 20 of 38
Component Evidence Code Pubs
located_in apical plasma membrane  
located_in axonal growth cone  
located_in basolateral plasma membrane  
located_in brush border membrane  
located_in cell surface  
located_in collagen-containing extracellular matrix  
located_in cytoplasm PubMed 
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in cytosol PubMed 
located_in cytosol  
located_in dendritic growth cone  
located_in endocytic vesicle lumen  
located_in extracellular exosome PubMed 
located_in extracellular region  
located_in ficolin-1-rich granule lumen  
located_in lysosomal lumen PubMed 
located_in melanosome  
located_in membrane PubMed 
located_in mitochondrion PubMed 
is_active_in myelin sheath  
is_active_in neuronal cell body  
located_in neuronal cell body  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
is_active_in nucleus  
located_in nucleus  
is_active_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
is_active_in plasma membrane  
located_in plasma membrane  
part_of protein-containing complex  
part_of protein-containing complex PubMed 
located_in secretory granule lumen  
located_in sperm mitochondrial sheath  
located_in sperm plasma membrane  
Items 1 - 20 of 38

General protein information

Preferred Names
heat shock protein HSP 90-alpha
Names
HSP 86
LPS-associated protein 2
epididymis luminal secretory protein 52
epididymis secretory sperm binding protein Li 65p
heat shock 86 kDa
heat shock 90kD protein 1, alpha
heat shock 90kD protein 1, alpha-like 4
heat shock 90kD protein, alpha-like 4
heat shock 90kDa protein 1, alpha
heat shock protein 90kDa alpha (cytosolic), class A member 1
heat shock protein 90kDa alpha family class A member 1
heat shock protein family C member 1
lipopolysaccharide-associated protein 2
renal carcinoma antigen NY-REN-38
NP_001017963.2
NP_005339.3
XP_011535020.1
XP_054231954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017963.3NP_001017963.2  heat shock protein HSP 90-alpha isoform 1

    See identical proteins and their annotated locations for NP_001017963.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI250920, AJ890083, BX248761, DA237149
    Consensus CDS
    CCDS32160.1
    UniProtKB/Swiss-Prot
    P07900
    UniProtKB/TrEMBL
    Q86SX1
    Related
    ENSP00000335153.7, ENST00000334701.11
    Conserved Domains (3) summary
    smart00387
    Location:162313
    HATPase_c; Histidine kinase-like ATPases
    PTZ00272
    Location:140854
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:318844
    HSP90; Hsp90 protein
  2. NM_005348.4NP_005339.3  heat shock protein HSP 90-alpha isoform 2

    See identical proteins and their annotated locations for NP_005339.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI250920, AJ890083, DC303876
    Consensus CDS
    CCDS9967.1
    UniProtKB/Swiss-Prot
    A8K500, B3KPJ9, P07900, Q2PP14, Q5CAQ6, Q5CAQ7, Q9BVQ5
    UniProtKB/TrEMBL
    K9JA46, Q8TBA7
    Related
    ENSP00000216281.8, ENST00000216281.13
    Conserved Domains (1) summary
    PTZ00272
    Location:18732
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102080742..102139749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536718.3XP_011535020.1  heat shock protein HSP 90-alpha isoform X1

    Conserved Domains (3) summary
    smart00387
    Location:161312
    HATPase_c; Histidine kinase-like ATPases
    PTZ00272
    Location:139853
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:317843
    HSP90; Hsp90 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    96316329..96375332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375979.1XP_054231954.1  heat shock protein HSP 90-alpha isoform X1

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