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Mxd4 Max dimerization protein 4 [ Mus musculus (house mouse) ]

Gene ID: 17122, updated on 9-Dec-2024

Summary

Official Symbol
Mxd4provided by MGI
Official Full Name
Max dimerization protein 4provided by MGI
Primary source
MGI:MGI:104991
See related
Ensembl:ENSMUSG00000037235 AllianceGenome:MGI:104991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mad4; bHLHc12; 2810410A03Rik
Summary
Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of DNA-templated transcription. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; craniocervical region bone; limb mesenchyme; skin; and thymus. Orthologous to human MXD4 (MAX dimerization protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 161.0), thymus adult (RPKM 147.7) and 26 other tissues See more
Orthologs
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Genomic context

See Mxd4 in Genome Data Viewer
Location:
5 B2; 5 17.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34331231..34345076, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34176580..34187710, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA polymerase N Neighboring gene RIKEN cDNA 4930557J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1299 Neighboring gene STARR-seq mESC enhancer starr_12836 Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34530746-34530855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34537815-34537924 Neighboring gene zinc finger, FYVE domain containing 28 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34575558-34575759 Neighboring gene cilia and flagella associated protein 99 Neighboring gene predicted gene 5553

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex PubMed 

General protein information

Preferred Names
max dimerization protein 4
Names
max dimerizer 4
max-associated protein 4
max-interacting transcriptional repressor MAD4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010753.3NP_034883.2  max dimerization protein 4

    See identical proteins and their annotated locations for NP_034883.2

    Status: VALIDATED

    Source sequence(s)
    AC157989
    Consensus CDS
    CCDS19212.1
    UniProtKB/TrEMBL
    Q91VN7, Q9D8P5
    Related
    ENSMUSP00000039071.7, ENSMUST00000042701.13
    Conserved Domains (1) summary
    cd18929
    Location:53140
    bHLHzip_Mad4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-associated protein 4 (Mad4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34331231..34345076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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