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Nfyb nuclear transcription factor-Y beta [ Mus musculus (house mouse) ]

Gene ID: 18045, updated on 9-Dec-2024

Summary

Official Symbol
Nfybprovided by MGI
Official Full Name
nuclear transcription factor-Y betaprovided by MGI
Primary source
MGI:MGI:97317
See related
Ensembl:ENSMUSG00000020248 AllianceGenome:MGI:97317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbf-A
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; early conceptus; genitourinary system; and nervous system. Orthologous to human NFYB (nuclear transcription factor Y subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 15.1), CNS E14 (RPKM 12.4) and 24 other tissues See more
Orthologs
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Genomic context

See Nfyb in Genome Data Viewer
Location:
10 C1; 10 40.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82584534..82599985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82748700..82764151, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10632 Neighboring gene STARR-positive B cell enhancer ABC_E6890 Neighboring gene STARR-positive B cell enhancer ABC_E578 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 6 Neighboring gene STARR-seq mESC enhancer starr_27366 Neighboring gene thymine DNA glycosylase Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:82129373-82129482 Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8353 Neighboring gene STARR-seq mESC enhancer starr_27367 Neighboring gene STARR-seq mESC enhancer starr_27368 Neighboring gene host cell factor C2 Neighboring gene STARR-positive B cell enhancer ABC_E6891 Neighboring gene STARR-seq mESC enhancer starr_27374 Neighboring gene RIKEN cDNA 1700028I16 gene Neighboring gene STARR-seq mESC enhancer starr_27375 Neighboring gene STARR-seq mESC enhancer starr_27376 Neighboring gene STARR-positive B cell enhancer ABC_E9798 Neighboring gene STARR-seq mESC enhancer starr_27377 Neighboring gene thioredoxin reductase 1 Neighboring gene STARR-seq mESC enhancer starr_27378 Neighboring gene predicted gene, 38560

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA binding  
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor binding  
enables DNA-binding transcription factor binding  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables protein heterodimerization activity  
enables protein-containing complex binding  
enables sequence-specific DNA binding PubMed 
contributes_to transcription cis-regulatory region binding PubMed 
contributes_to transcription cis-regulatory region binding  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex  
part_of CCAAT-binding factor complex  
part_of RNA polymerase II transcription regulator complex  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus PubMed 
part_of protein-DNA complex  
part_of protein-DNA complex  
part_of transcription regulator complex PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit beta
Names
CAAT box DNA-binding protein subunit B
NF-YB
nuclear transcription factor Y subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428686.1NP_001415615.1  nuclear transcription factor Y subunit beta isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC155709
    UniProtKB/Swiss-Prot
    P22569, P63139, Q3UK54
    UniProtKB/TrEMBL
    Q9D056
  2. NM_001428687.1NP_001415616.1  nuclear transcription factor Y subunit beta isoform b

    Status: VALIDATED

    Source sequence(s)
    AC155709
  3. NM_010914.3NP_035044.1  nuclear transcription factor Y subunit beta isoform a

    See identical proteins and their annotated locations for NP_035044.1

    Status: VALIDATED

    Source sequence(s)
    AC155709
    Consensus CDS
    CCDS48654.1
    UniProtKB/Swiss-Prot
    P22569, P63139, Q3UK54
    UniProtKB/TrEMBL
    Q9D056
    Related
    ENSMUSP00000122403.2, ENSMUST00000130911.8
    Conserved Domains (1) summary
    pfam00808
    Location:57122
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    82584534..82599985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243380.3XP_011241682.1  nuclear transcription factor Y subunit beta isoform X2

    Conserved Domains (1) summary
    pfam00808
    Location:247
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  2. XM_011243379.4XP_011241681.1  nuclear transcription factor Y subunit beta isoform X1

    Conserved Domains (1) summary
    pfam00808
    Location:57122
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  3. XM_011243381.4XP_011241683.1  nuclear transcription factor Y subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011241683.1

    Conserved Domains (1) summary
    pfam00808
    Location:247
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
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