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Ccnf cyclin F [ Mus musculus (house mouse) ]

Gene ID: 12449, updated on 9-Dec-2024

Summary

Official Symbol
Ccnfprovided by MGI
Official Full Name
cyclin Fprovided by MGI
Primary source
MGI:MGI:102551
See related
Ensembl:ENSMUSG00000072082 AllianceGenome:MGI:102551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CycF; Fbxo1
Summary
Predicted to enable anaphase-promoting complex binding activity and cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within negative regulation of centrosome duplication; placenta development; and re-entry into mitotic cell cycle. Predicted to be located in cell junction; centriole; and centrosome. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in liver lobe; midbrain ventricular layer; and telencephalon. Orthologous to human CCNF (cyclin F). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in liver E14.5 (RPKM 29.9), thymus adult (RPKM 27.8) and 18 other tissues See more
Orthologs
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Genomic context

See Ccnf in Genome Data Viewer
Location:
17 A3.3; 17 12.32 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24441518..24470333, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24223230..24251409, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene STARR-seq mESC enhancer starr_42081 Neighboring gene microRNA 5134 Neighboring gene STARR-seq mESC enhancer starr_42082 Neighboring gene microRNA 6965 Neighboring gene ATP-binding cassette, sub-family A member 17 Neighboring gene STARR-seq mESC enhancer starr_42083 Neighboring gene STARR-positive B cell enhancer ABC_E9436 Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene predicted gene, 25618

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex  
part_of SCF ubiquitin ligase complex  
located_in cell junction  
located_in cell junction  
located_in centriole  
located_in centriole  
located_in centrosome  
located_in centrosome  
part_of cyclin-dependent protein kinase holoenzyme complex  
is_active_in cytoplasm  
is_active_in microtubule organizing center  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  
located_in perinuclear region of cytoplasm  

General protein information

Preferred Names
cyclin-F
Names
G2/mitotic-specific cyclin-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409800.1NP_001396729.1  cyclin-F isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117577
  2. NM_001409801.1NP_001396730.1  cyclin-F isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117577
  3. NM_001409803.1NP_001396732.1  cyclin-F isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117577
  4. NM_001409804.1NP_001396733.1  cyclin-F isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC117577
  5. NM_001409805.1NP_001396734.1  cyclin-F isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC117577
  6. NM_001409806.1NP_001396735.1  cyclin-F isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC117577
  7. NM_001409807.1NP_001396736.1  cyclin-F isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC117577
  8. NM_001409808.1NP_001396737.1  cyclin-F isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC117577
  9. NM_001409809.1NP_001396738.1  cyclin-F isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117577
  10. NM_001409832.1NP_001396761.1  cyclin-F isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC117577
  11. NM_007634.5NP_031660.3  cyclin-F isoform 4

    See identical proteins and their annotated locations for NP_031660.3

    Status: VALIDATED

    Source sequence(s)
    AC117577
    Consensus CDS
    CCDS37484.1
    UniProtKB/Swiss-Prot
    P51944, Q3TF73, Q60797, Q60799, Q8BSX9, Q8C4D9, Q8CI26
    Related
    ENSMUSP00000111048.4, ENSMUST00000115390.5
    Conserved Domains (3) summary
    smart00256
    Location:3573
    FBOX; A Receptor for Ubiquitination Targets
    pfam00134
    Location:281406
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:425531
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24441518..24470333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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