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Prodh proline dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 19125, updated on 9-Dec-2024

Summary

Official Symbol
Prodhprovided by MGI
Official Full Name
proline dehydrogenaseprovided by MGI
Primary source
MGI:MGI:97770
See related
Ensembl:ENSMUSG00000003526 AllianceGenome:MGI:97770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pro1; Pro-1; Ym24d07
Summary
Predicted to enable FAD binding activity; amino acid binding activity; and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate and regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Located in mitochondrion. Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; forelimb bud; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in liver adult (RPKM 99.9), kidney adult (RPKM 99.6) and 17 other tissues See more
Orthologs
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Genomic context

See Prodh in Genome Data Viewer
Location:
16 A3; 16 11.19 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17889593..17907147, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18071726..18089283, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 49580 Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18075403-18075586 Neighboring gene predicted gene, 52241 Neighboring gene reticulon 4 receptor Neighboring gene predicted gene, 53937

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Spontaneous (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC159030

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding  
enables FAD binding  
enables FAD binding  
enables amino acid binding  
enables amino acid binding  
enables proline dehydrogenase activity  
enables proline dehydrogenase activity  
enables proline dehydrogenase activity PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle  
located_in mitochondrial inner membrane PubMed 
located_in mitochondrial matrix  
located_in mitochondrion PubMed 
is_active_in mitochondrion  
located_in mitochondrion PubMed 
located_in mitochondrion  
located_in nucleoplasm  

General protein information

Preferred Names
proline dehydrogenase 1, mitochondrial
Names
proline dehydrogenase, mitochondrial
proline oxidase
NP_035302.2
XP_006521926.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011172.3NP_035302.2  proline dehydrogenase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_035302.2

    Status: VALIDATED

    Source sequence(s)
    AC087064
    Consensus CDS
    CCDS37278.1
    UniProtKB/Swiss-Prot
    A0JLW6, Q3UNR4, Q9QX61, Q9WU79
    UniProtKB/TrEMBL
    A0A0R4J1T9
    Related
    ENSMUSP00000003620.6, ENSMUST00000003620.13
    Conserved Domains (2) summary
    PLN02681
    Location:47594
    PLN02681; proline dehydrogenase
    pfam01619
    Location:343570
    Pro_dh; Proline dehydrogenase

RNA

  1. NR_189733.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087064

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17889593..17907147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521863.2XP_006521926.1  proline dehydrogenase 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006521926.1

    Conserved Domains (1) summary
    cl33545
    Location:88516
    PutA_N; Proline utilization A N-terminal domain

RNA

  1. XR_001781795.1 RNA Sequence

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