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Snx8 sorting nexin 8 [ Mus musculus (house mouse) ]

Gene ID: 231834, updated on 9-Dec-2024

Summary

Official Symbol
Snx8provided by MGI
Official Full Name
sorting nexin 8provided by MGI
Primary source
MGI:MGI:2443816
See related
Ensembl:ENSMUSG00000029560 AllianceGenome:MGI:2443816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B130023O14Rik
Summary
Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in early endosome to Golgi transport and intracellular protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Is expressed in cerebral cortex ventricular layer and small intestine. Orthologous to human SNX8 (sorting nexin 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 15.1), spleen adult (RPKM 10.6) and 28 other tissues See more
Orthologs
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Genomic context

See Snx8 in Genome Data Viewer
Location:
5 G2; 5 78.95 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140326048..140375063, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140340293..140389308, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene MAD1 mitotic arrest deficient 1-like 1 Neighboring gene predicted gene, 30492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140619500-140619609 Neighboring gene STARR-seq mESC enhancer starr_14706 Neighboring gene STARR-seq mESC enhancer starr_14707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140684659-140684995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140686457-140686707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140691391-140691751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140736675-140736858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140740159-140740368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140747294-140747554 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140758495-140758709 Neighboring gene STARR-positive B cell enhancer ABC_E6391 Neighboring gene STARR-seq mESC enhancer starr_14708 Neighboring gene nudix hydrolase 1 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E9018 Neighboring gene STARR-positive B cell enhancer ABC_E9267 Neighboring gene STARR-positive B cell enhancer ABC_E1696 Neighboring gene predicted gene, 30550 Neighboring gene microRNA 7038 Neighboring gene eukaryotic translation initiation factor 3, subunit B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding  
enables identical protein binding  
enables phosphatidylinositol binding  
enables phosphatidylinositol binding  
Process Evidence Code Pubs
involved_in early endosome to Golgi transport  
involved_in early endosome to Golgi transport  
involved_in early endosome to Golgi transport  
involved_in intracellular protein transport  
involved_in intracellular protein transport  
involved_in intracellular protein transport  
Component Evidence Code Pubs
located_in cytosol  
is_active_in early endosome membrane  
located_in early endosome membrane  
located_in early endosome membrane  
located_in intracellular membrane-bounded organelle  
part_of retromer complex  
part_of retromer complex  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172277.3NP_758481.1  sorting nexin-8

    See identical proteins and their annotated locations for NP_758481.1

    Status: VALIDATED

    Source sequence(s)
    AC131670, AK148429
    Consensus CDS
    CCDS39356.1
    UniProtKB/Swiss-Prot
    Q8BLI6, Q8BUQ7, Q8CFD4
    UniProtKB/TrEMBL
    Q3U0I9
    Related
    ENSMUSP00000031539.8, ENSMUST00000031539.12
    Conserved Domains (2) summary
    cd06866
    Location:70173
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cd07597
    Location:190434
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140326048..140375063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254436.2XP_030110296.1  sorting nexin-8 isoform X3

    UniProtKB/TrEMBL
    Q3U0I9
    Conserved Domains (2) summary
    cd06866
    Location:70173
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cd07597
    Location:176407
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
  2. XM_036165098.1XP_036020991.1  sorting nexin-8 isoform X6

    Conserved Domains (1) summary
    cd07597
    Location:1242
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
  3. XM_006504673.4XP_006504736.1  sorting nexin-8 isoform X2

    UniProtKB/TrEMBL
    Q3U0I9
    Conserved Domains (2) summary
    cd06866
    Location:71174
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cd07597
    Location:177408
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
  4. XM_006504672.2XP_006504735.1  sorting nexin-8 isoform X1

    UniProtKB/TrEMBL
    Q3U0I9
    Related
    ENSMUSP00000142556.2, ENSMUST00000196566.5
    Conserved Domains (2) summary
    cd06866
    Location:71174
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cd07597
    Location:191435
    BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
  5. XM_030254437.2XP_030110297.1  sorting nexin-8 isoform X5

    Conserved Domains (2) summary
    cd06866
    Location:70173
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cl12013
    Location:190300
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. XM_006504674.5XP_006504737.1  sorting nexin-8 isoform X4

    Conserved Domains (2) summary
    cd06866
    Location:71174
    PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
    cl12013
    Location:191301
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001784687.3 RNA Sequence

    Related
    ENSMUST00000197880.5
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