U.S. flag

An official website of the United States government

SULF2 sulfatase 2 [ Homo sapiens (human) ]

Gene ID: 55959, updated on 10-Dec-2024

Summary

Official Symbol
SULF2provided by HGNC
Official Full Name
sulfatase 2provided by HGNC
Primary source
HGNC:HGNC:20392
See related
Ensembl:ENSG00000196562 MIM:610013; AllianceGenome:HGNC:20392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSULF-2
Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 36.6) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SULF2 in Genome Data Viewer
Location:
20q13.12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (47657406..47786627, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (49395801..49525734, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46286150..46415371, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr20.2047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12980 Neighboring gene RNA, U6 small nuclear 563, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46152763-46153530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46158187-46158687 Neighboring gene nuclear receptor coactivator 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:46190110-46190292 Neighboring gene MPRA-validated peak4234 silencer Neighboring gene ribosomal protein S3A pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46276897-46277614 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46277615-46278332 Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46293563-46294548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46294549-46295532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46303203-46304168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46307531-46308031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46316712-46317262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46317263-46317814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46326206-46326710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339340-46339840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339841-46340341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381087-46381588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381589-46382088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386138-46386895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386896-46387654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46387655-46388411 Neighboring gene NANOG hESC enhancer GRCh37_chr20:46390145-46390683 Neighboring gene Sharpr-MPRA regulatory region 8498 Neighboring gene uncharacterized LOC124904922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18007 Neighboring gene uncharacterized LOC124904920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18008 Neighboring gene uncharacterized LOC124904921 Neighboring gene uncharacterized LOC107985401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46428971-46429590 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46432238-46433192 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46433193-46434147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46437768-46438349 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46438350-46438930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46454838-46455538 Neighboring gene RNA, U7 small nuclear 173 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common variation in GPC5 is associated with acquired nephrotic syndrome.
EBI GWAS Catalog
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
EBI GWAS Catalog

Interactions

General gene information

Clone Names

  • FLJ44488, FLJ90554, KIAA1247, MGC126411, DKFZp313E091

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity  
enables N-acetylglucosamine-6-sulfatase activity PubMed 
enables N-acetylglucosamine-6-sulfatase activity PubMed 
enables arylsulfatase activity PubMed 
enables arylsulfatase activity PubMed 
enables calcium ion binding  
enables glycosaminoglycan binding  
Process Evidence Code Pubs
involved_in bone development  
involved_in cartilage development  
involved_in chondrocyte development  
involved_in embryonic skeletal system development  
involved_in esophagus smooth muscle contraction  
involved_in glial cell-derived neurotrophic factor receptor signaling pathway  
involved_in glomerular basement membrane development  
involved_in glomerular basement membrane development  
involved_in glomerular filtration  
involved_in heparan sulfate proteoglycan metabolic process  
involved_in heparan sulfate proteoglycan metabolic process PubMed 
involved_in heparan sulfate proteoglycan metabolic process PubMed 
involved_in innervation  
involved_in kidney development  
involved_in liver regeneration  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
involved_in positive regulation of Wnt signaling pathway  
involved_in positive regulation of Wnt signaling pathway PubMed 
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in positive regulation of endothelin production  
involved_in positive regulation of vascular endothelial growth factor production  
involved_in positive regulation of vascular endothelial growth factor production  
involved_in regulation of hepatocyte proliferation  
involved_in response to wounding  
Component Evidence Code Pubs
located_in Golgi stack  
is_active_in cell surface  
located_in cell surface PubMed 
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum PubMed 
located_in extracellular region PubMed 
located_in extracellular space PubMed 
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
extracellular sulfatase Sulf-2
Names
N-acetylglucosamine-6-sulfatase
arylsulfatase
NP_001155313.1
NP_001373977.1
NP_001373978.1
NP_001373979.1
NP_001373980.1
NP_001373981.1
NP_001373982.1
NP_001373983.1
NP_001373984.1
NP_061325.1
NP_940998.2
XP_047296251.1
XP_047296252.1
XP_047296253.1
XP_047296254.1
XP_047296255.1
XP_047296256.1
XP_047296257.1
XP_054179677.1
XP_054179678.1
XP_054179679.1
XP_054179680.1
XP_054179681.1
XP_054179682.1
XP_054179683.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161841.2NP_001155313.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001155313.1

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
    Related
    ENSP00000418290.1, ENST00000484875.5
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529661
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  2. NM_001387048.1NP_001373977.1  extracellular sulfatase Sulf-2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
    Related
    ENSP00000508753.1, ENST00000688720.1
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529661
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  3. NM_001387049.1NP_001373978.1  extracellular sulfatase Sulf-2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529661
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  4. NM_001387050.1NP_001373979.1  extracellular sulfatase Sulf-2 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  5. NM_001387051.1NP_001373980.1  extracellular sulfatase Sulf-2 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529661
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  6. NM_001387052.1NP_001373981.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  7. NM_001387053.1NP_001373982.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  8. NM_001387054.1NP_001373983.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  9. NM_001387055.1NP_001373984.1  extracellular sulfatase Sulf-2 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529662
    DUF3740; Sulfatase protein
    cl23718
    Location:750799
    ALP_like; alkaline phosphatases and sulfatases
  10. NM_018837.4NP_061325.1  extracellular sulfatase Sulf-2 isoform a precursor

    See identical proteins and their annotated locations for NP_061325.1

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13408.1
    UniProtKB/Swiss-Prot
    E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
    Related
    ENSP00000353007.4, ENST00000359930.8
    Conserved Domains (3) summary
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:529661
    DUF3740; Sulfatase protein
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases
  11. NM_198596.3NP_940998.2  extracellular sulfatase Sulf-2 isoform b precursor

    See identical proteins and their annotated locations for NP_940998.2

    Status: VALIDATED

    Source sequence(s)
    AL034418, AL121777, AL354813
    Consensus CDS
    CCDS13409.2
    UniProtKB/Swiss-Prot
    Q8IWU5
    Related
    ENSP00000418442.1, ENST00000467815.5
    Conserved Domains (4) summary
    COG3119
    Location:43395
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    pfam12548
    Location:535661
    DUF3740; Sulfatase protein
    cd16147
    Location:43385
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    cl23718
    Location:749798
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    47657406..47786627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440296.1XP_047296252.1  extracellular sulfatase Sulf-2 isoform X2

    UniProtKB/Swiss-Prot
    E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
  2. XM_047440295.1XP_047296251.1  extracellular sulfatase Sulf-2 isoform X1

  3. XM_047440297.1XP_047296253.1  extracellular sulfatase Sulf-2 isoform X3

  4. XM_047440300.1XP_047296256.1  extracellular sulfatase Sulf-2 isoform X4

  5. XM_047440298.1XP_047296254.1  extracellular sulfatase Sulf-2 isoform X3

  6. XM_047440299.1XP_047296255.1  extracellular sulfatase Sulf-2 isoform X4

  7. XM_047440301.1XP_047296257.1  extracellular sulfatase Sulf-2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    49395801..49525734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323703.1XP_054179678.1  extracellular sulfatase Sulf-2 isoform X6

    UniProtKB/Swiss-Prot
    E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
  2. XM_054323702.1XP_054179677.1  extracellular sulfatase Sulf-2 isoform X5

  3. XM_054323704.1XP_054179679.1  extracellular sulfatase Sulf-2 isoform X3

  4. XM_054323706.1XP_054179681.1  extracellular sulfatase Sulf-2 isoform X4

  5. XM_054323705.1XP_054179680.1  extracellular sulfatase Sulf-2 isoform X3

  6. XM_054323707.1XP_054179682.1  extracellular sulfatase Sulf-2 isoform X4

  7. XM_054323708.1XP_054179683.1  extracellular sulfatase Sulf-2 isoform X4

External link. Please review our privacy policy.