U.S. flag

An official website of the United States government

F2rl2 coagulation factor II thrombin receptor like 2 [ Mus musculus (house mouse) ]

Gene ID: 14064, updated on 9-Dec-2024

Summary

Official Symbol
F2rl2provided by MGI
Official Full Name
coagulation factor II thrombin receptor like 2provided by MGI
Primary source
MGI:MGI:1298208
See related
Ensembl:ENSMUSG00000021675 AllianceGenome:MGI:1298208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAR3; F730031A08
Summary
Enables proteinase-activated receptor activity and receptor ligand activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Located in apical plasma membrane. Is expressed in several structures, including central nervous system; liver; retina; skin; and spleen. Orthologous to human F2RL2 (coagulation factor II thrombin receptor like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in liver E14.5 (RPKM 6.6), spleen adult (RPKM 5.4) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See F2rl2 in Genome Data Viewer
Location:
13 D1; 13 50.38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95833428..95839276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95696920..95702768)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene predicted gene, 33074 Neighboring gene predicted gene, 48745 Neighboring gene predicted gene, 52062 Neighboring gene STARR-seq mESC enhancer starr_35329 Neighboring gene predicted gene, 32702

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
is_active_in plasma membrane  
part_of protein-containing complex  
part_of protein-containing complex  

General protein information

Preferred Names
proteinase-activated receptor 3
Names
PAR-3
Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
coagulation factor II receptor-like 2
protease-activated receptor 3
thrombin receptor-like 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010170.4NP_034300.3  proteinase-activated receptor 3 precursor

    See identical proteins and their annotated locations for NP_034300.3

    Status: VALIDATED

    Source sequence(s)
    AC171003
    Consensus CDS
    CCDS26702.1
    UniProtKB/Swiss-Prot
    B9EIT2, O08675, Q3UXV3
    UniProtKB/TrEMBL
    Q8BJB7
    Related
    ENSMUSP00000022182.5, ENSMUST00000022182.5
    Conserved Domains (2) summary
    pfam00001
    Location:112357
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:104312
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95833428..95839276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.