U.S. flag

An official website of the United States government

Trdn triadin [ Mus musculus (house mouse) ]

Gene ID: 76757, updated on 9-Dec-2024

Summary

Official Symbol
Trdnprovided by MGI
Official Full Name
triadinprovided by MGI
Primary source
MGI:MGI:1924007
See related
Ensembl:ENSMUSG00000019787 AllianceGenome:MGI:1924007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TDN; EG432451; 2310045H21Rik
Summary
Predicted to enable protein-macromolecule adaptor activity. Involved in heart contraction. Acts upstream of or within establishment of localization in cell; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and response to bacterium. Predicted to be located in cytosol; nucleoplasm; and sarcoplasmic reticulum. Predicted to be part of calcium channel complex and junctional membrane complex. Predicted to be active in junctional sarcoplasmic reticulum membrane and plasma membrane. Is expressed in embryo and heart. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia and catecholaminergic polymorphic ventricular tachycardia 5. Orthologous to human TRDN (triadin). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in heart adult (RPKM 10.6), mammary gland adult (RPKM 3.0) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Trdn in Genome Data Viewer
Location:
10 A4; 10 18.37 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (32959479..33352705)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (33083483..33476709)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Na+/K+ transporting ATPase interacting 2 Neighboring gene STARR-seq mESC enhancer starr_26223 Neighboring gene STARR-seq mESC enhancer starr_26224 Neighboring gene STARR-seq mESC enhancer starr_26225 Neighboring gene Braf transforming gene pseudogene Neighboring gene STARR-seq mESC enhancer starr_26226 Neighboring gene STARR-seq mESC enhancer starr_26227 Neighboring gene Smad nuclear interacting protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26228 Neighboring gene STARR-seq mESC enhancer starr_26229 Neighboring gene STARR-seq mESC enhancer starr_26230 Neighboring gene STARR-seq mESC enhancer starr_26231 Neighboring gene STARR-seq mESC enhancer starr_26233 Neighboring gene STARR-seq mESC enhancer starr_26234 Neighboring gene STARR-seq mESC enhancer starr_26235 Neighboring gene STARR-seq mESC enhancer starr_26236 Neighboring gene STARR-seq mESC enhancer starr_26237 Neighboring gene STARR-seq mESC enhancer starr_26238 Neighboring gene STARR-seq mESC enhancer starr_26239 Neighboring gene RIKEN cDNA D830005E20 gene Neighboring gene STARR-seq mESC enhancer starr_26243 Neighboring gene STARR-seq mESC enhancer starr_26245 Neighboring gene STARR-seq mESC enhancer starr_26246 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26247 Neighboring gene STARR-seq mESC enhancer starr_26248 Neighboring gene lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog Neighboring gene predicted gene, 20304 Neighboring gene STARR-seq mESC enhancer starr_26250 Neighboring gene clavesin 2 Neighboring gene STARR-seq mESC enhancer starr_26251 Neighboring gene STARR-seq mESC enhancer starr_26252 Neighboring gene predicted gene 15939 Neighboring gene sulfotransferase family 3A, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding PubMed 
enables protein-macromolecule adaptor activity  
enables signaling receptor binding  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization  
involved_in endoplasmic reticulum membrane organization  
acts_upstream_of_or_within establishment of localization in cell PubMed 
involved_in heart contraction  
acts_upstream_of_or_within heart contraction PubMed 
involved_in heart contraction PubMed 
involved_in heart contraction  
involved_in intracellular calcium ion homeostasis  
involved_in negative regulation of release of sequestered calcium ion into cytosol  
involved_in positive regulation of release of sequestered calcium ion into cytosol  
involved_in regulation of cardiac muscle cell membrane potential  
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum PubMed 
acts_upstream_of_or_within response to bacterium PubMed 
Component Evidence Code Pubs
part_of calcium channel complex  
located_in cytosol  
located_in cytosol  
part_of junctional membrane complex  
is_active_in junctional sarcoplasmic reticulum membrane  
located_in junctional sarcoplasmic reticulum membrane  
located_in membrane PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in sarcoplasmic reticulum  
located_in sarcoplasmic reticulum membrane  

General protein information

Preferred Names
triadin
Names
cardiac triadin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364696.1NP_001351625.1  triadin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153965, AC157017
    Consensus CDS
    CCDS87986.1
    UniProtKB/TrEMBL
    A0A1W2P8G7
    Related
    ENSMUSP00000152042.2, ENSMUST00000219982.2
    Conserved Domains (1) summary
    pfam05279
    Location:5073
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  2. NM_001364697.1NP_001351626.1  triadin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153965, AC157017
    Consensus CDS
    CCDS87985.1
    UniProtKB/TrEMBL
    A0A1W2P8G7
    Related
    ENSMUSP00000151583.2, ENSMUST00000217779.2
    Conserved Domains (1) summary
    pfam05279
    Location:5073
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
  3. NM_029726.2NP_084002.2  triadin isoform 1

    See identical proteins and their annotated locations for NP_084002.2

    Status: VALIDATED

    Source sequence(s)
    AC109214, AC153966, AC157017, AI642378, AK009816, AK036470, BB658668
    Consensus CDS
    CCDS48532.1
    UniProtKB/Swiss-Prot
    E9Q9K5, Q8VIN7, Q8VIN8, Q8VIN9, Q9CV36
    Related
    ENSMUSP00000093436.5, ENSMUST00000095762.5
    Conserved Domains (2) summary
    PTZ00121
    Location:383646
    PTZ00121; MAEBL; Provisional
    pfam05279
    Location:4574
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    32959479..33352705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.