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Csnk1e casein kinase 1, epsilon [ Mus musculus (house mouse) ]

Gene ID: 27373, updated on 9-Dec-2024

Summary

Official Symbol
Csnk1eprovided by MGI
Official Full Name
casein kinase 1, epsilonprovided by MGI
Primary source
MGI:MGI:1351660
See related
Ensembl:ENSMUSG00000022433 AllianceGenome:MGI:1351660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tau; CKIe; CK1epsilon; KC1epsilon
Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Expression
Broad expression in whole brain E14.5 (RPKM 28.8), CNS E14 (RPKM 28.1) and 25 other tissues See more
Orthologs
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Genomic context

See Csnk1e in Genome Data Viewer
Location:
15 37.71 cM; 15 E1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79302054..79339779, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79417852..79455579, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943 Neighboring gene STARR-seq mESC enhancer starr_39180 Neighboring gene STARR-seq mESC enhancer starr_39181 Neighboring gene predicted gene 16059 Neighboring gene STARR-seq mESC enhancer starr_39185 Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 30
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein binding PubMed 
enables protein kinase activity PubMed 
enables protein kinase activity PubMed 
enables protein kinase activity PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway  
involved_in cellular response to nerve growth factor stimulus  
involved_in chromatin remodeling  
involved_in circadian behavior  
involved_in circadian behavior  
involved_in circadian regulation of gene expression PubMed 
acts_upstream_of_or_within circadian rhythm PubMed 
involved_in endocytosis  
acts_upstream_of_or_within negative regulation of Wnt signaling pathway PubMed 
involved_in positive regulation of Wnt signaling pathway PubMed 
involved_in positive regulation of amyloid-beta formation  
involved_in positive regulation of amyloid-beta formation  
involved_in positive regulation of canonical Wnt signaling pathway  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway PubMed 
involved_in positive regulation of non-canonical Wnt signaling pathway PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
acts_upstream_of_or_within protein localization PubMed 
acts_upstream_of_or_within protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
involved_in regulation of circadian rhythm PubMed 
involved_in regulation of protein localization PubMed 
involved_in signal transduction  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in growth cone  
located_in growth cone  
located_in neuronal cell body  
located_in neuronal cell body  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
part_of ribonucleoprotein complex PubMed 

General protein information

Preferred Names
casein kinase I isoform epsilon; casein kinase I
Names
CKI-epsilon
KC1 epsilon
NP_001276827.1
NP_001276828.1
NP_001346791.1
NP_001346792.1
NP_001398803.1
NP_001398804.1
NP_001398805.1
NP_001398806.1
NP_001398807.1
NP_001398808.1
NP_001398809.1
NP_001398810.1
NP_038795.3
XP_006521106.1
XP_011243952.1
XP_011243953.1
XP_011243954.1
XP_011243955.1
XP_011243956.1
XP_017172146.1
XP_017172149.1
XP_030104453.1
XP_030104457.1
XP_036015339.1
XP_036015340.1
XP_036015341.1
XP_036015342.1
XP_036015343.1
XP_036015344.1
XP_036015345.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289898.3NP_001276827.1  casein kinase I isoform epsilon isoform a

    See identical proteins and their annotated locations for NP_001276827.1

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Related
    ENSMUSP00000113341.2, ENSMUST00000117786.9
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. NM_001289899.2NP_001276828.1  casein kinase I isoform epsilon isoform b

    See identical proteins and their annotated locations for NP_001276828.1

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS70646.1
    UniProtKB/TrEMBL
    Q3TYE1
    Related
    ENSMUSP00000113096.2, ENSMUST00000122044.8
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  3. NM_001359862.2NP_001346791.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  4. NM_001359863.2NP_001346792.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  5. NM_001411874.1NP_001398803.1  casein kinase I isoform epsilon isoform b

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/TrEMBL
    Q3TYE1
  6. NM_001411875.1NP_001398804.1  casein kinase I isoform epsilon isoform b

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/TrEMBL
    Q3TYE1
  7. NM_001411876.1NP_001398805.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
  8. NM_001411877.1NP_001398806.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
  9. NM_001411878.1NP_001398807.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
  10. NM_001411879.1NP_001398808.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
  11. NM_001411880.1NP_001398809.1  casein kinase I isoform epsilon isoform a

    Status: VALIDATED

    Source sequence(s)
    AC165278
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
  12. NM_001411881.1NP_001398810.1  casein kinase I isoform epsilon isoform c

    Status: VALIDATED

    Source sequence(s)
    AC165278
  13. NM_013767.8NP_038795.3  casein kinase I isoform epsilon isoform a

    See identical proteins and their annotated locations for NP_038795.3

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27640.1
    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Related
    ENSMUSP00000113975.2, ENSMUST00000120859.9
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79302054..79339779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245651.2XP_011243953.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243953.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. XM_036159448.1XP_036015341.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  3. XM_011245652.3XP_011243954.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243954.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  4. XM_011245653.4XP_011243955.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243955.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  5. XM_017316657.2XP_017172146.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  6. XM_006521043.4XP_006521106.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006521106.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  7. XM_036159446.1XP_036015339.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  8. XM_036159451.1XP_036015344.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  9. XM_011245650.4XP_011243952.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243952.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  10. XM_030248593.1XP_030104453.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  11. XM_036159447.1XP_036015340.1  casein kinase I isoform X1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  12. XM_011245654.4XP_011243956.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_011243956.1

    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  13. XM_036159450.1XP_036015343.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  14. XM_036159452.1XP_036015345.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  15. XM_036159449.1XP_036015342.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  16. XM_030248597.2XP_030104457.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q8R389, Q9JMK2
    UniProtKB/TrEMBL
    Q9QUI3
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  17. XM_017316660.2XP_017172149.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    Q3TYE1
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
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