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VEGFA vascular endothelial growth factor A [ Homo sapiens (human) ]

Gene ID: 7422, updated on 10-Dec-2024

Summary

Official Symbol
VEGFAprovided by HGNC
Official Full Name
vascular endothelial growth factor Aprovided by HGNC
Primary source
HGNC:HGNC:12680
See related
Ensembl:ENSG00000112715 MIM:192240; AllianceGenome:HGNC:12680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VPF; VEGF; MVCD1; L-VEGF
Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression
Broad expression in thyroid (RPKM 146.9), prostate (RPKM 69.5) and 21 other tissues See more
Orthologs
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Genomic context

See VEGFA in Genome Data Viewer
Location:
6p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43770211..43786487)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43599724..43616002)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43737948..43754224)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43670641-43671626 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:43674891-43675733 Neighboring gene EXOSC8 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24614 Neighboring gene Sharpr-MPRA regulatory region 12588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43726130-43726666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43728022-43728522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43728523-43729023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43732509-43733010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17241 Neighboring gene H3K27ac hESC enhancers GRCh37_chr6:43738373-43739138 and GRCh37_chr6:43739139-43739904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43739905-43740670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43740671-43741436 Neighboring gene Sharpr-MPRA regulatory region 8365 Neighboring gene uncharacterized LOC105375070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43766999-43767583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24618 Neighboring gene Sharpr-MPRA regulatory region 5169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24620 Neighboring gene uncharacterized LOC105375069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43818433-43819079 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43819080-43819726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43819727-43820373 Neighboring gene long intergenic non-protein coding RNA 2537

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Microvascular complications of diabetes, susceptibility to, 1
MedGen: C2676832 OMIM: 603933 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2023-08-23)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2023-08-23)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Items 1 - 10 of 13
Description
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
EBI GWAS Catalog
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
EBI GWAS Catalog
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.
EBI GWAS Catalog
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
EBI GWAS Catalog
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
EBI GWAS Catalog
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
EBI GWAS Catalog
Seven new loci associated with age-related macular degeneration.
EBI GWAS Catalog
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
EBI GWAS Catalog
Items 1 - 10 of 13

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
Nef nef HIV-1 Nef synergizes with IL-6 to enhance vascular tube formation, cell proliferation, VEGF expression, and phosphorylated AKT activation in human umbilical vein endothelial cells PubMed
nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
Tat tat HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A or FGF-2. PubMed
tat VEGF can compete with HIV-1 Tat chemotactic activity in Kaposi's sarcoma (KS) cells, indicating Tat may cooperate with VEGF in activation of VEGFR-2 on KS precursor spindle and endothelial cells and contribute to the aggressiveness of AIDS-KS lesions PubMed
tat HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells PubMed
tat HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells PubMed
tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
tat HIV-1 Tat enhances Kaposi's sarcoma-associated herpesvirus vIL-6-induced cell proliferation, cellular transformation, vascular tube formation, and VEGF production in tumor cells PubMed
tat HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF PubMed
tat The chemokine like region of HIV-1 Tat (amino acids 24-51) induces the release of angiogenic factors, including vascular endothelial growth factor (VEGF), an effect linked to Tat induced angiogenesis PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to upregulate expression of profibrogenic markers COL-1, PCT, SMA-1, VEGF, and MMP2, which is inhibited by MIF treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC70609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity  
enables chemoattractant activity PubMed 
enables chemoattractant activity  
enables cytokine activity PubMed 
enables cytokine activity  
enables extracellular matrix binding PubMed 
enables fibronectin binding PubMed 
enables growth factor activity  
enables growth factor activity PubMed 
enables growth factor activity  
enables heparin binding PubMed 
enables heparin binding PubMed 
enables identical protein binding PubMed 
enables neuropilin binding PubMed 
enables platelet-derived growth factor receptor binding PubMed 
enables protein binding PubMed 
enables protein homodimerization activity  
enables receptor ligand activity PubMed 
enables receptor ligand activity PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity PubMed 
enables vascular endothelial growth factor receptor 1 binding PubMed 
enables vascular endothelial growth factor receptor 2 binding PubMed 
enables vascular endothelial growth factor receptor binding  
enables vascular endothelial growth factor receptor binding PubMed 
Items 1 - 25 of 146
Process Evidence Code Pubs
involved_in VEGF-activated neuropilin signaling pathway PubMed 
involved_in VEGF-activated neuropilin signaling pathway  
involved_in angiogenesis PubMed 
involved_in apoptotic process  
involved_in artery morphogenesis  
involved_in basophil chemotaxis PubMed 
involved_in bone trabecula formation  
acts_upstream_of_or_within branching involved in blood vessel morphogenesis PubMed 
involved_in branching involved in blood vessel morphogenesis PubMed 
involved_in camera-type eye morphogenesis  
involved_in cardiac muscle cell development  
involved_in cardiac vascular smooth muscle cell development  
involved_in cell maturation  
involved_in cell migration involved in sprouting angiogenesis PubMed 
involved_in cell-cell adhesion  
acts_upstream_of_or_within cellular response to hypoxia PubMed 
involved_in cellular response to hypoxia PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus PubMed 
involved_in cellular stress response to acid chemical PubMed 
involved_in commissural neuron axon guidance  
involved_in coronary artery morphogenesis  
involved_in coronary vein morphogenesis  
involved_in dopaminergic neuron differentiation  
involved_in endothelial cell chemotaxis PubMed 
involved_in endothelial cell proliferation  
involved_in epithelial cell differentiation  
involved_in epithelial cell maturation  
involved_in eye photoreceptor cell development  
involved_in heart morphogenesis  
involved_in homeostasis of number of cells within a tissue  
involved_in in utero embryonic development  
involved_in induction of positive chemotaxis  
involved_in induction of positive chemotaxis PubMed 
involved_in induction of positive chemotaxis PubMed 
involved_in kidney development  
involved_in lactation  
involved_in lung development  
involved_in lung vasculature development  
involved_in lymph vessel morphogenesis  
involved_in lymphangiogenesis  
involved_in macrophage differentiation PubMed 
involved_in mammary gland alveolus development  
involved_in mesoderm development  
involved_in monocyte differentiation PubMed 
involved_in motor neuron migration  
involved_in negative regulation of adherens junction organization PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of blood-brain barrier permeability PubMed 
involved_in negative regulation of cell-cell adhesion mediated by cadherin PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity PubMed 
involved_in negative regulation of epithelial to mesenchymal transition  
involved_in negative regulation of establishment of endothelial barrier PubMed 
involved_in negative regulation of fat cell differentiation  
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of gene expression PubMed 
acts_upstream_of negative regulation of miRNA transcription PubMed 
involved_in negative regulation of transcription by RNA polymerase II PubMed 
involved_in nervous system development PubMed 
involved_in neuroblast proliferation  
involved_in outflow tract morphogenesis  
involved_in ovarian follicle development  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in positive chemotaxis PubMed 
involved_in positive chemotaxis  
involved_in positive chemotaxis  
involved_in positive regulation of DNA biosynthetic process PubMed 
involved_in positive regulation of DNA biosynthetic process PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of MAPK cascade PubMed 
involved_in positive regulation of angiogenesis PubMed 
involved_in positive regulation of angiogenesis PubMed 
involved_in positive regulation of axon extension involved in axon guidance  
involved_in positive regulation of blood vessel endothelial cell migration PubMed 
involved_in positive regulation of blood vessel endothelial cell migration PubMed 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis PubMed 
acts_upstream_of positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis PubMed 
involved_in positive regulation of branching involved in ureteric bud morphogenesis  
involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of cell adhesion PubMed 
involved_in positive regulation of cell division  
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway PubMed 
involved_in positive regulation of cold-induced thermogenesis PubMed 
involved_in positive regulation of endothelial cell chemotaxis PubMed 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway PubMed 
involved_in positive regulation of endothelial cell migration PubMed 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation PubMed 
involved_in positive regulation of endothelial cell proliferation PubMed 
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of epithelial cell proliferation  
involved_in positive regulation of epithelial tube formation PubMed 
involved_in positive regulation of focal adhesion assembly PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of leukocyte migration PubMed 
involved_in positive regulation of lymphangiogenesis  
involved_in positive regulation of mast cell chemotaxis  
involved_in positive regulation of mast cell chemotaxis PubMed 
involved_in positive regulation of neuroblast proliferation  
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of p38MAPK cascade PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in positive regulation of positive chemotaxis PubMed 
involved_in positive regulation of protein autophosphorylation PubMed 
involved_in positive regulation of protein localization to early endosome PubMed 
involved_in positive regulation of protein phosphorylation PubMed 
involved_in positive regulation of protein-containing complex assembly PubMed 
involved_in positive regulation of receptor internalization PubMed 
involved_in positive regulation of sprouting angiogenesis PubMed 
involved_in positive regulation of sprouting angiogenesis PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of trophoblast cell migration PubMed 
involved_in positive regulation of vascular endothelial growth factor signaling pathway PubMed 
involved_in positive regulation of vascular permeability PubMed 
involved_in post-embryonic camera-type eye development  
involved_in primitive erythrocyte differentiation  
involved_in regulation of cell shape PubMed 
involved_in regulation of hematopoietic progenitor cell differentiation  
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction PubMed 
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in response to hypoxia  
involved_in response to hypoxia PubMed 
involved_in retinal ganglion cell axon guidance  
involved_in sprouting angiogenesis  
involved_in surfactant homeostasis  
involved_in tube formation PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway  
involved_in vascular endothelial growth factor receptor signaling pathway PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway PubMed 
involved_in vascular endothelial growth factor receptor-2 signaling pathway PubMed 
involved_in vascular endothelial growth factor signaling pathway  
involved_in vascular endothelial growth factor signaling pathway PubMed 
involved_in vascular endothelial growth factor signaling pathway PubMed 
involved_in vascular endothelial growth factor signaling pathway PubMed 
involved_in vascular wound healing PubMed 
involved_in vasculogenesis PubMed 
involved_in vasodilation  
Items 1 - 25 of 146
Component Evidence Code Pubs
located_in Golgi apparatus  
part_of VEGF-A complex PubMed 
located_in adherens junction PubMed 
located_in cell surface PubMed 
located_in cytoplasm PubMed 
located_in endoplasmic reticulum  
located_in extracellular matrix PubMed 
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in membrane  
located_in nucleus  
located_in platelet alpha granule lumen  
located_in secretory granule PubMed 

General protein information

Preferred Names
vascular endothelial growth factor A, long form
Names
vascular endothelial growth factor A121
vascular endothelial growth factor A165
vascular permeability factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008732.1 RefSeqGene

    Range
    4996..21272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025366.3NP_001020537.2  vascular endothelial growth factor A, long form isoform a

    Status: REVIEWED

    Source sequence(s)
    AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, S85192
    Consensus CDS
    CCDS34457.1
    UniProtKB/TrEMBL
    J3KPA4
    Related
    ENSP00000361125.5, ENST00000372055.9
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:364412
    VEGF_C; VEGF heparin-binding domain
  2. NM_001025367.3NP_001020538.2  vascular endothelial growth factor A, long form isoform c

    Status: REVIEWED

    Source sequence(s)
    AF024710, AJ010438, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47433.1
    UniProtKB/TrEMBL
    A0A0A0MSI7
    Related
    ENSP00000389864.4, ENST00000413642.8
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:341389
    VEGF_C; VEGF heparin-binding domain
  3. NM_001025368.3NP_001020539.2  vascular endothelial growth factor A, long form isoform d

    Status: REVIEWED

    Source sequence(s)
    AB021221, AF024710, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS34458.1
    UniProtKB/TrEMBL
    H3BLW8
    Related
    ENSP00000361137.4, ENST00000372067.8
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:318371
    VEGF_C; VEGF heparin-binding domain
  4. NM_001025369.3NP_001020540.2  vascular endothelial growth factor A, long form isoform e

    See identical proteins and their annotated locations for NP_001020540.2

    Status: REVIEWED

    Source sequence(s)
    AF024710, AF091352, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47435.1
    UniProtKB/TrEMBL
    A0A0A0MSH7
    Related
    ENSP00000388663.3, ENST00000417285.7
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:318353
    VEGF_C; VEGF heparin-binding domain
  5. NM_001025370.3NP_001020541.2  vascular endothelial growth factor A, long form isoform f

    Status: REVIEWED

    Source sequence(s)
    AF024710, AF214570, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47434.1
    UniProtKB/TrEMBL
    A0A0A0MRQ4
    Related
    ENSP00000361134.5, ENST00000372064.9
    Conserved Domains (1) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  6. NM_001033756.3NP_001028928.1  vascular endothelial growth factor A, long form isoform g

    See identical proteins and their annotated locations for NP_001028928.1

    Status: REVIEWED

    Source sequence(s)
    AF024710, AF430806, BF700556, BM661679, BU153227, CN256173, DA237741
    Consensus CDS
    CCDS47432.1
    UniProtKB/TrEMBL
    A0A0A0MTB2
    Related
    ENSP00000421561.2, ENST00000482630.7
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:318365
    VEGF_C; VEGF heparin-binding domain
  7. NM_001171622.2NP_001165093.1  vascular endothelial growth factor A, long form isoform h

    Status: REVIEWED

    Source sequence(s)
    AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, DQ229900
    Consensus CDS
    CCDS55007.1
    UniProtKB/TrEMBL
    A0A0A0MR43
    Related
    ENSP00000317598.7, ENST00000324450.11
    Conserved Domains (1) summary
    smart00141
    Location:230311
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  8. NM_001171623.2NP_001165094.1  vascular endothelial growth factor A, long form isoform i precursor

    See identical proteins and their annotated locations for NP_001165094.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55010.1
    Related
    ENSP00000430479.1, ENST00000523873.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:184232
    VEGF_C; VEGF heparin-binding domain
  9. NM_001171624.2NP_001165095.1  vascular endothelial growth factor A, long form isoform j precursor

    See identical proteins and their annotated locations for NP_001165095.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55009.1
    Related
    ENSP00000428321.1, ENST00000520948.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:167215
    VEGF_C; VEGF heparin-binding domain
  10. NM_001171625.2NP_001165096.1  vascular endothelial growth factor A, long form isoform k precursor

    See identical proteins and their annotated locations for NP_001165096.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55008.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000430829.1, ENST00000518689.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:161209
    VEGF_C; VEGF heparin-binding domain
  11. NM_001171626.2NP_001165097.1  vascular endothelial growth factor A, long form isoform VEGF-A precursor

    See identical proteins and their annotated locations for NP_001165097.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55012.1
    UniProtKB/TrEMBL
    A0A0Y0IMM4
    Related
    ENSP00000429643.1, ENST00000523950.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:143191
    VEGF_C; VEGF heparin-binding domain
  12. NM_001171627.2NP_001165098.1  vascular endothelial growth factor A, long form isoform m precursor

    See identical proteins and their annotated locations for NP_001165098.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55011.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000429008.1, ENST00000523125.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:143173
    VEGF_C; VEGF heparin-binding domain
  13. NM_001171628.2NP_001165099.1  vascular endothelial growth factor A, long form isoform n precursor

    See identical proteins and their annotated locations for NP_001165099.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55014.1
    UniProtKB/TrEMBL
    A0A0Y0J542
    Related
    ENSP00000361148.4, ENST00000372077.8
    Conserved Domains (1) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  14. NM_001171629.2NP_001165100.1  vascular endothelial growth factor A, long form isoform o precursor

    See identical proteins and their annotated locations for NP_001165100.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55013.1
    UniProtKB/Swiss-Prot
    P15692
    Related
    ENSP00000430002.1, ENST00000518824.5
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:143185
    VEGF_C; VEGF heparin-binding domain
  15. NM_001171630.2NP_001165101.1  vascular endothelial growth factor A, long form isoform p precursor

    See identical proteins and their annotated locations for NP_001165101.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    Consensus CDS
    CCDS55015.1
    UniProtKB/TrEMBL
    A0A0Y0J542
    Related
    ENSP00000409911.2, ENST00000457104.6
    Conserved Domains (1) summary
    smart00141
    Location:50131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  16. NM_001204384.2NP_001191313.1  vascular endothelial growth factor A, long form isoform q precursor

    See identical proteins and their annotated locations for NP_001191313.1

    Status: REVIEWED

    Source sequence(s)
    AL136131
    UniProtKB/Swiss-Prot
    P15692
    Conserved Domains (1) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  17. NM_001204385.2NP_001191314.1  vascular endothelial growth factor A, long form isoform r

    Status: REVIEWED

    Source sequence(s)
    AL136131, BC065522, M27281
    UniProtKB/TrEMBL
    H0YBZ0
    Related
    ENSP00000430594.1, ENST00000519767.5
    Conserved Domains (1) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  18. NM_001287044.2NP_001273973.1  vascular endothelial growth factor A, long form isoform s

    See identical proteins and their annotated locations for NP_001273973.1

    Status: REVIEWED

    Source sequence(s)
    AL136131, BC058855, BC065522, BX442364, HY066915
    Consensus CDS
    CCDS69125.1
    UniProtKB/TrEMBL
    A2A2V4
    Related
    ENSP00000230480.6, ENST00000230480.10
    Conserved Domains (2) summary
    smart00141
    Location:22104
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:115163
    VEGF_C; VEGF heparin-binding domain
  19. NM_001317010.2NP_001303939.1  vascular endothelial growth factor A, long form isoform VEGF-Ax precursor

    Status: REVIEWED

    Source sequence(s)
    AL136131
    UniProtKB/Swiss-Prot
    P15692
    Conserved Domains (2) summary
    smart00141
    Location:50132
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:143191
    VEGF_C; VEGF heparin-binding domain
  20. NM_003376.6NP_003367.4  vascular endothelial growth factor A, long form isoform b

    See identical proteins and their annotated locations for NP_003367.4

    Status: REVIEWED

    Source sequence(s)
    AF024710, BF700556, BM661679, BU153227, CN256173, DA237741, M27281
    Consensus CDS
    CCDS4907.2
    UniProtKB/Swiss-Prot
    B5BU86, H0Y2S8, H0Y407, H0Y414, H0Y462, H0Y8N2, H3BLW7, O60720, O75875, P15692, Q074Z4, Q16889, Q5UB46, Q6P0P5, Q96KJ0, Q96L82, Q96NW5, Q9H1W8, Q9H1W9, Q9UH58, Q9UL23
    UniProtKB/TrEMBL
    A0A0A0MSI7
    Related
    ENSP00000500082.3, ENST00000672860.3
    Conserved Domains (2) summary
    smart00141
    Location:230312
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:347395
    VEGF_C; VEGF heparin-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43770211..43786487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43599724..43616002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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