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Bmp2k BMP2 inducible kinase [ Mus musculus (house mouse) ]

Gene ID: 140780, updated on 9-Dec-2024

Summary

Official Symbol
Bmp2kprovided by MGI
Official Full Name
BMP2 inducible kinaseprovided by MGI
Primary source
MGI:MGI:2155456
See related
Ensembl:ENSMUSG00000034663 AllianceGenome:MGI:2155456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIKE; 4933417M22Rik
Summary
Enables phosphatase regulator activity and protein kinase activity. Acts upstream of or within regulation of bone mineralization. Located in nucleus. Is expressed in early conceptus and secondary oocyte. Orthologous to human BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 8.0), spleen adult (RPKM 7.8) and 28 other tissues See more
Orthologs
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Genomic context

See Bmp2k in Genome Data Viewer
Location:
5 E3; 5 47.29 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (97143588..97239809)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96997672..97091048)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33370 Neighboring gene predicted gene 8013 Neighboring gene predicted gene, 46916 Neighboring gene STARR-positive B cell enhancer ABC_E11294 Neighboring gene STARR-seq mESC enhancer starr_13683 Neighboring gene STARR-positive B cell enhancer ABC_E1303 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:97425959-97426223 Neighboring gene predicted gene 9484 Neighboring gene STARR-positive B cell enhancer ABC_E3589 Neighboring gene STARR-seq mESC enhancer starr_13685 Neighboring gene STARR-seq mESC enhancer starr_13686 Neighboring gene progestin and adipoQ receptor family member III Neighboring gene STARR-positive B cell enhancer mm9_chr5:97540551-97540852 Neighboring gene predicted gene, 33609 Neighboring gene STARR-seq mESC enhancer starr_13687 Neighboring gene predicted gene 2861

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 27
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables AP-2 adaptor complex binding  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables phosphatase regulator activity  
enables phosphatase regulator activity PubMed 
enables protein kinase activity PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 27
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in nuclear speck  
located_in nuclear speck  
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
BMP-2-inducible protein kinase
NP_001406725.1
NP_001406726.1
NP_542439.1
XP_006534851.1
XP_006534852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419796.1NP_001406725.1  BMP-2-inducible protein kinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121887, AC125229
  2. NM_001419797.1NP_001406726.1  BMP-2-inducible protein kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121887, AC125229
    Related
    ENSMUSP00000108598.2, ENSMUST00000112974.6
  3. NM_080708.2NP_542439.1  BMP-2-inducible protein kinase isoform 1

    See identical proteins and their annotated locations for NP_542439.1

    Status: VALIDATED

    Source sequence(s)
    AC121887, AC125229
    Consensus CDS
    CCDS39175.1
    UniProtKB/Swiss-Prot
    Q8C8L7, Q91Z96
    Related
    ENSMUSP00000037970.8, ENSMUST00000035635.10
    Conserved Domains (3) summary
    smart00220
    Location:49308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14037
    Location:44317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam15282
    Location:8731138
    BMP2K_C; BMP-2-inducible protein kinase C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    97143588..97239809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534788.5XP_006534851.1  BMP-2-inducible protein kinase isoform X2

    Conserved Domains (2) summary
    cd14037
    Location:44317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam12144
    Location:501582
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
  2. XM_006534789.5XP_006534852.1  BMP-2-inducible protein kinase isoform X3

    Conserved Domains (2) summary
    cd14037
    Location:44317
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    pfam12144
    Location:501582
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
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