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    Fndc4 fibronectin type III domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 64339, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fndc4provided by MGI
    Official Full Name
    fibronectin type III domain containing 4provided by MGI
    Primary source
    MGI:MGI:1917195
    See related
    Ensembl:ENSMUSG00000038552 AllianceGenome:MGI:1917195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FRCP1; Fnmp1; 2810430J06Rik; 6330410H20Rik
    Summary
    Involved in negative regulation of inflammatory response. Located in endoplasmic reticulum; extracellular space; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FNDC4 (fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 37.1), CNS E18 (RPKM 36.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Fndc4 in Genome Data Viewer
    Location:
    5 B1; 5 17.27 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31449589..31453279, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31292242..31295935, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene keratinocyte associated protein 3 Neighboring gene intraflagellar transport 172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31593577-31593686 Neighboring gene glucokinase regulatory protein Neighboring gene STARR-seq mESC enhancer starr_12769 Neighboring gene predicted gene, 19457

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in endoplasmic reticulum PubMed 
    is_active_in extracellular region  
    located_in extracellular space PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    fibronectin type III domain-containing protein 4
    Names
    fibronectin type III repeat containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356945.2NP_001343874.1  fibronectin type III domain-containing protein 4 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC114619
      Conserved Domains (1) summary
      cd00063
      Location:43133
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_001356946.2NP_001343875.1  fibronectin type III domain-containing protein 4 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC114619
      Consensus CDS
      CCDS19181.1
      UniProtKB/Swiss-Prot
      Q3TR08, Q810E5, Q9CYY4
      UniProtKB/TrEMBL
      A0A0J9YUI2, B9EI95
      Related
      ENSMUSP00000047185.8, ENSMUST00000041266.11
      Conserved Domains (1) summary
      cd00063
      Location:43133
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. NM_001378890.1NP_001365819.1  fibronectin type III domain-containing protein 4 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC114619
      Conserved Domains (1) summary
      cd00063
      Location:43133
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. NM_022424.7NP_071869.2  fibronectin type III domain-containing protein 4 isoform b precursor

      See identical proteins and their annotated locations for NP_071869.2

      Status: VALIDATED

      Source sequence(s)
      AC114619
      Consensus CDS
      CCDS19181.1
      UniProtKB/Swiss-Prot
      Q3TR08, Q810E5, Q9CYY4
      UniProtKB/TrEMBL
      A0A0J9YUI2, B9EI95
      Related
      ENSMUSP00000127404.2, ENSMUST00000172435.8
      Conserved Domains (1) summary
      cd00063
      Location:43133
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31449589..31453279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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