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Csf3r colony stimulating factor 3 receptor [ Mus musculus (house mouse) ]

Gene ID: 12986, updated on 9-Dec-2024

Summary

Official Symbol
Csf3rprovided by MGI
Official Full Name
colony stimulating factor 3 receptorprovided by MGI
Primary source
MGI:MGI:1339755
See related
Ensembl:ENSMUSG00000028859 AllianceGenome:MGI:1339755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd114; Csfgr; G-CSFR; G-CSF-R
Summary
Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within neutrophil chemotaxis and regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including aorta-gonad-mesonephros; bone marrow; early conceptus; gut; and male reproductive gland or organ. Used to study hereditary neutrophilia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hereditary neutrophilia; and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in spleen adult (RPKM 12.5), lung adult (RPKM 7.8) and 12 other tissues See more
Orthologs
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Genomic context

See Csf3r in Genome Data Viewer
Location:
4 D2.2; 4 59.77 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125917241..125938233)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126023441..126044975)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40249 Neighboring gene RIKEN cDNA 2610028E06 gene Neighboring gene STARR-positive B cell enhancer ABC_E6216 Neighboring gene STARR-seq mESC enhancer starr_11388 Neighboring gene predicted gene, 32908 Neighboring gene STARR-positive B cell enhancer ABC_E2121 Neighboring gene STARR-positive B cell enhancer ABC_E3512 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene organic solute carrier partner 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC141472, MGC141473

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity  
enables cytokine receptor activity  
enables granulocyte colony-stimulating factor binding PubMed 
enables protein binding PubMed 
Component Evidence Code Pubs
located_in endocytic vesicle membrane  
is_active_in external side of plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
granulocyte colony-stimulating factor receptor
Names
G-CSF receptor
colony stimulating factor 3 receptor (granulocyte)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252651.2NP_001239580.1  granulocyte colony-stimulating factor receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239580.1

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/TrEMBL
    Q14BI3
    Conserved Domains (4) summary
    smart00060
    Location:422503
    FN3; Fibronectin type 3 domain
    cd00063
    Location:246318
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001420891.1NP_001407820.1  granulocyte colony-stimulating factor receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
  3. NM_001420892.1NP_001407821.1  granulocyte colony-stimulating factor receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
  4. NM_001420893.1NP_001407822.1  granulocyte colony-stimulating factor receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
  5. NM_001420894.1NP_001407823.1  granulocyte colony-stimulating factor receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
    Related
    ENSMUSP00000030673.7, ENSMUST00000030673.7
  6. NM_001420895.1NP_001407824.1  granulocyte colony-stimulating factor receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
  7. NM_001420896.1NP_001407825.1  granulocyte colony-stimulating factor receptor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/TrEMBL
    Q14AY3
  8. NM_007782.4NP_031808.2  granulocyte colony-stimulating factor receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_031808.2

    Status: VALIDATED

    Source sequence(s)
    AL627101
    Consensus CDS
    CCDS18640.1
    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
    Related
    ENSMUSP00000101768.2, ENSMUST00000106162.8
    Conserved Domains (4) summary
    smart00060
    Location:530611
    FN3; Fibronectin type 3 domain
    cd00063
    Location:354426
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_045561.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627101
  2. NR_185211.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627101
  3. NR_185212.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627101
  4. NR_185213.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627101
  5. NR_185214.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627101

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125917241..125938233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502709.3XP_006502772.1  granulocyte colony-stimulating factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006502772.1

    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
    Conserved Domains (4) summary
    smart00060
    Location:530611
    FN3; Fibronectin type 3 domain
    cd00063
    Location:354426
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_017319945.3XP_017175434.1  granulocyte colony-stimulating factor receptor isoform X5

    Conserved Domains (3) summary
    smart00060
    Location:223304
    FN3; Fibronectin type 3 domain
    cd00063
    Location:47119
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:126211
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_006502710.5XP_006502773.1  granulocyte colony-stimulating factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006502773.1

    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
    Conserved Domains (4) summary
    smart00060
    Location:530611
    FN3; Fibronectin type 3 domain
    cd00063
    Location:354426
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_036163628.1XP_036019521.1  granulocyte colony-stimulating factor receptor isoform X3

    UniProtKB/TrEMBL
    Q14AY3
    Conserved Domains (2) summary
    smart00060
    Location:397478
    FN3; Fibronectin type 3 domain
    cd00063
    Location:221293
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_006502711.5XP_006502774.1  granulocyte colony-stimulating factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006502774.1

    UniProtKB/Swiss-Prot
    A2A8Y3, P40223
    UniProtKB/TrEMBL
    Q14AY3
    Conserved Domains (4) summary
    smart00060
    Location:530611
    FN3; Fibronectin type 3 domain
    cd00063
    Location:354426
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. XM_011240423.4XP_011238725.1  granulocyte colony-stimulating factor receptor isoform X2

    See identical proteins and their annotated locations for XP_011238725.1

    UniProtKB/TrEMBL
    Q14BI3
    Conserved Domains (4) summary
    smart00060
    Location:422503
    FN3; Fibronectin type 3 domain
    cd00063
    Location:246318
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  7. XM_006502717.3XP_006502780.1  granulocyte colony-stimulating factor receptor isoform X3

    See identical proteins and their annotated locations for XP_006502780.1

    UniProtKB/TrEMBL
    Q14AY3
    Conserved Domains (2) summary
    smart00060
    Location:397478
    FN3; Fibronectin type 3 domain
    cd00063
    Location:221293
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  8. XM_006502719.3XP_006502782.1  granulocyte colony-stimulating factor receptor isoform X6

    Conserved Domains (2) summary
    smart00060
    Location:172253
    FN3; Fibronectin type 3 domain
    cl21522
    Location:75160
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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