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    AKIRIN2 akirin 2 [ Homo sapiens (human) ]

    Gene ID: 55122, updated on 10-Dec-2024

    Summary

    Official Symbol
    AKIRIN2provided by HGNC
    Official Full Name
    akirin 2provided by HGNC
    Primary source
    HGNC:HGNC:21407
    See related
    Ensembl:ENSG00000135334 MIM:615165; AllianceGenome:HGNC:21407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBI1; C6orf166; dJ486L4.2
    Summary
    Enables enzyme binding activity; identical protein binding activity; and protein-macromolecule adaptor activity. Involved in proteasome localization and protein import into nucleus. Acts upstream of with a positive effect on nuclear protein quality control by the ubiquitin-proteasome system. Located in nucleoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 25.3), spleen (RPKM 21.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AKIRIN2 in Genome Data Viewer
    Location:
    6q15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (87674860..87702233, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (88883172..88910565, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (88384578..88411951, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member A1 Neighboring gene RNA, U6 small nuclear 444, pseudogene Neighboring gene arginyl-tRNA synthetase 2, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24797 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:88298835-88299796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:88301170-88301670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:88301671-88302171 Neighboring gene NANOG hESC enhancer GRCh37_chr6:88313800-88314301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:88323459-88323960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:88349062-88349578 Neighboring gene origin recognition complex subunit 3 Neighboring gene MPRA-validated peak5943 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr6:88408207-88408726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24802 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24805 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:88445010-88445674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24808 Neighboring gene uncharacterized LOC101928911 Neighboring gene FOXA motif-containing MPRA enhancer 167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:88505589-88506090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:88506091-88506590 Neighboring gene NANOG hESC enhancer GRCh37_chr6:88508442-88508943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24810 Neighboring gene RNA, 7SL, cytoplasmic 183, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • FLJ10342

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein-macromolecule adaptor activity PubMed 
    enables transcription coregulator activity  
    Process Evidence Code Pubs
    involved_in adaptive immune response  
    involved_in cerebral cortex development  
    involved_in defense response to bacterium  
    involved_in embryo development ending in birth or egg hatching  
    involved_in innate immune response  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_positive_effect nuclear protein quality control by the ubiquitin-proteasome system PubMed 
    involved_in positive regulation of B cell activation  
    involved_in positive regulation of adaptive immune response  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of innate immune response  
    involved_in positive regulation of innate immune response  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in proteasome localization PubMed 
    involved_in protein import into nucleus PubMed 
    involved_in regulation of muscle cell differentiation  
    involved_in response to lipopolysaccharide  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytoplasm  
    located_in membrane  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of transcription repressor complex  

    General protein information

    Preferred Names
    akirin-2
    Names
    fourteen-three-three beta interactant 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018064.4NP_060534.1  akirin-2

      See identical proteins and their annotated locations for NP_060534.1

      Status: VALIDATED

      Source sequence(s)
      AK001204, BC000764, BM996262
      Consensus CDS
      CCDS5013.1
      UniProtKB/Swiss-Prot
      Q53H80, Q9BQB1
      Related
      ENSP00000257787.5, ENST00000257787.6
      Conserved Domains (1) summary
      cd22244
      Location:2203
      akirin-2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      87674860..87702233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      88883172..88910565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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