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    Rhbdl2 rhomboid like 2 [ Mus musculus (house mouse) ]

    Gene ID: 230726, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rhbdl2provided by MGI
    Official Full Name
    rhomboid like 2provided by MGI
    Primary source
    MGI:MGI:3608413
    See related
    Ensembl:ENSMUSG00000043333 AllianceGenome:MGI:3608413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RRP2; 9130416B15
    Summary
    Enables serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Is expressed in several structures, including adipose tissue; bone; genitourinary system; liver; and spleen. Orthologous to human RHBDL2 (rhomboid like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 4.9), colon adult (RPKM 4.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rhbdl2 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123681642..123723993)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123787875..123830196)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6212 Neighboring gene predicted gene, 57730 Neighboring gene akirin 1 Neighboring gene STARR-positive B cell enhancer ABC_E1654 Neighboring gene STARR-seq mESC enhancer starr_11313 Neighboring gene STARR-seq mESC enhancer starr_11314 Neighboring gene eukaryotic translation initiation factor 2C, 2 pseudogene Neighboring gene RIKEN cDNA 1700121C08 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    rhomboid-related protein 2
    Names
    rhomboid, veinlet-like 2
    NP_001343374.1
    NP_898986.2
    XP_006503088.1
    XP_036019936.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356445.2NP_001343374.1  rhomboid-related protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683811
      Conserved Domains (1) summary
      pfam01694
      Location:51203
      Rhomboid; Rhomboid family
    2. NM_183163.3NP_898986.2  rhomboid-related protein 2 isoform 1

      See identical proteins and their annotated locations for NP_898986.2

      Status: VALIDATED

      Source sequence(s)
      AL683811
      Consensus CDS
      CCDS38873.1
      UniProtKB/Swiss-Prot
      A2AGA4
      Related
      ENSMUSP00000054546.6, ENSMUST00000053202.12
      Conserved Domains (1) summary
      pfam01694
      Location:115264
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      123681642..123723993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503025.5XP_006503088.1  rhomboid-related protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006503088.1

      UniProtKB/Swiss-Prot
      A2AGA4
      Related
      ENSMUSP00000101810.2, ENSMUST00000106204.2
      Conserved Domains (1) summary
      pfam01694
      Location:115264
      Rhomboid; Rhomboid family
    2. XM_036164043.1XP_036019936.1  rhomboid-related protein 2 isoform X2

      Conserved Domains (1) summary
      pfam01694
      Location:51203
      Rhomboid; Rhomboid family
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