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Frs2 fibroblast growth factor receptor substrate 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314850, updated on 9-Dec-2024

Summary

Official Symbol
Frs2provided by RGD
Official Full Name
fibroblast growth factor receptor substrate 2provided by RGD
Primary source
RGD:1308201
See related
EnsemblRapid:ENSRNOG00000005642 AllianceGenome:RGD:1308201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable fibroblast growth factor receptor binding activity; neurotrophin TRKA receptor binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in cellular response to fibroblast growth factor stimulus and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in adherens junction and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 84.8), Adrenal (RPKM 82.7) and 9 other tissues See more
Orthologs
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Genomic context

See Frs2 in Genome Data Viewer
Location:
7q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54597182..54678656, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52711255..52792738, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60128506..60210482, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing 10 Neighboring gene chaperonin containing TCP1 subunit 2 Neighboring gene uncharacterized LOC120093600 Neighboring gene mitochondrial ribosomal protein L47, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior axis specification, embryo  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cellular response to fibroblast growth factor stimulus PubMed 
involved_in fibroblast growth factor receptor signaling pathway  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway  
acts_upstream_of_or_within forebrain development  
acts_upstream_of_or_within gastrulation with mouth forming second  
acts_upstream_of_or_within lens development in camera-type eye  
acts_upstream_of_or_within lens fiber cell development  
acts_upstream_of_or_within lens placode formation involved in camera-type eye formation  
involved_in negative regulation of cardiac muscle cell differentiation  
acts_upstream_of_or_within neuroblast proliferation  
acts_upstream_of_or_within organ induction  
acts_upstream_of_or_within positive regulation of MAPK cascade  
involved_in positive regulation of vascular associated smooth muscle cell proliferation PubMed 
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade  
acts_upstream_of_or_within regulation of apoptotic process  
acts_upstream_of_or_within regulation of epithelial cell proliferation  
acts_upstream_of_or_within ventricular septum development  
Component Evidence Code Pubs
located_in adherens junction  
is_active_in cell-cell junction  
located_in cell-cell junction  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in plasma membrane  

General protein information

Preferred Names
fibroblast growth factor receptor substrate 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108097.4NP_001101567.2  fibroblast growth factor receptor substrate 2

    See identical proteins and their annotated locations for NP_001101567.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6A9E6, A6IGR5, D4A244
    Related
    ENSRNOP00000007472.4, ENSRNOT00000007472.8
    Conserved Domains (1) summary
    cd01202
    Location:15106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    54597182..54678656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079125.2XP_038935053.1  fibroblast growth factor receptor substrate 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9E6, A6IGR5, D4A244
    Conserved Domains (1) summary
    cd01202
    Location:15106
    PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
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