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    TFAM mitochondrial transcription factor A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42433, updated on 17-Dec-2024

    Summary

    Official Symbol
    TFAMprovided by FlyBase
    Official Full Name
    mitochondrial transcription factor Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038805
    Locus tag
    Dmel_CG4217
    See related
    AllianceGenome:FB:FBgn0038805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4217; d-mttfa; D-mtTFA; d-tfam; d-TFAM; Dmel\CG4217; DmtTFA; mttfa; mtTFA; MTTFA; tfam; Tfam
    Summary
    Predicted to enable mitochondrial promoter sequence-specific DNA binding activity and mitochondrial transcription factor activity. Involved in response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See TFAM in Genome Data Viewer
    Location:
    92F2-92F2; 3-69 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20575245..20577010, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16400967..16402732, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Elongin B

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding, bending  
    enables mitochondrial promoter sequence-specific DNA binding  
    enables mitochondrial transcription factor activity  
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    mitochondrial transcription factor A
    Names
    CG4217-PA
    CG4217-PB
    TFAM-PA
    TFAM-PB
    mitochondiral transcription fctor a
    mitochondrial transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20575245..20577010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169906.2 → NP_732527.1  mitochondrial transcription factor A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BR8
      Related
      FBpp0083356
      Conserved Domains (1) summary
      cd01390
      Location:78 → 142
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    2. NM_079691.3 → NP_524415.1  mitochondrial transcription factor A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDL2
      Related
      FBpp0083355
      Conserved Domains (1) summary
      cd01390
      Location:51 → 115
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
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