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    Fbxl4 F box and leucine-rich-repeat gene 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32378, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl4provided by FlyBase
    Official Full Name
    F box and leucine-rich-repeat gene 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0030555
    Locus tag
    Dmel_CG1839
    See related
    AllianceGenome:FB:FBgn0030555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1839; dFbxl4; Dmel\CG1839; fbxl4; FBXL4
    Summary
    Involved in several processes, including negative regulation of cell communication; negative regulation of circadian sleep/wake cycle, sleep; and protein polyubiquitination. Located in neuron projection and neuronal cell body. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Fbxl4 in Genome Data Viewer
    Location:
    12E5-12E5; 1-48 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14234413..14237923, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14128446..14131956, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene uncharacterized protein Neighboring gene Dihydrouridine synthase 2 Neighboring gene mRNA-capping-enzyme

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    part_of SCF ubiquitin ligase complex  
    located_in neuron projection PubMed 
    located_in neuronal cell body PubMed 

    General protein information

    Preferred Names
    F box and leucine-rich-repeat gene 4
    Names
    CG1839-PA
    Fbxl4-PA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14234413..14237923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132723.3 → NP_572951.1  F box and leucine-rich-repeat gene 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0S4, Q9VY46
      Related
      FBpp0073740
      Conserved Domains (4) summary
      cd09293
      Location:552 → 660
      AMN1; Antagonist of mitotic exit network protein 1
      cd00116
      Location:437 → 641
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:449 → 474
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:326 → 372
      F-box-like; F-box-like
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