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Ance Angiotensin converting enzyme [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34805, updated on 9-Dec-2024

Summary

Official Symbol
Anceprovided by FlyBase
Official Full Name
Angiotensin converting enzymeprovided by FlyBase
Primary source
FLYBASE:FBgn0012037
Locus tag
Dmel_CG8827
See related
AllianceGenome:FB:FBgn0012037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACE; ance; AnCE; ANCE; anon-EST:fe3D10; BG:DS08220.3; CG8827; Dmel\CG8827; race; Race; RACE
Summary
Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including metamorphosis; peptide hormone processing; and response to symbiotic bacterium. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; epidermis; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Ance in Genome Data Viewer
Location:
34E2-34E2; 2-50 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13905645..13909212)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13905645..13909212)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Centaurin gamma 1A Neighboring gene long non-coding RNA:CR44848 Neighboring gene Smg5 nonsense mediated mRNA decay factor Neighboring gene Ance-2 Neighboring gene Acylphosphatase

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metallopeptidase activity  
enables metallopeptidase activity PubMed 
enables metallopeptidase activity  
enables peptidyl-dipeptidase activity PubMed 
enables peptidyl-dipeptidase activity  
Process Evidence Code Pubs
involved_in metamorphosis PubMed 
involved_in peptide hormone processing PubMed 
involved_in proteolysis PubMed 
involved_in proteolysis  
involved_in response to symbiotic bacterium PubMed 
involved_in sexual reproduction PubMed 
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in membrane  
is_active_in plasma membrane  

General protein information

Preferred Names
angiotensin converting enzyme
Names
Ance-PA
Ance-PB
Ance-PC
CG8827-PA
CG8827-PB
CG8827-PC
angiotensin I-converting enzyme
angiotensin-converting enzyme
anon-fast-evolving-3D10
race
related to angiotensin converting enzyme
NP_001285915.1
NP_477046.1
NP_723852.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13905645..13909212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057698.5 → NP_477046.1  angiotensin converting enzyme, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477046.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
    UniProtKB/TrEMBL
    X2J8C3
    Related
    FBpp0080129
    Conserved Domains (1) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme
  2. NM_001298986.1 → NP_001285915.1  angiotensin converting enzyme, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285915.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
    UniProtKB/TrEMBL
    X2J8C3
    Conserved Domains (1) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme
  3. NM_165070.3 → NP_723852.1  angiotensin converting enzyme, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0P3, Q10714, Q27572, Q9NKE4, Q9TX66, Q9VJV3
    UniProtKB/TrEMBL
    X2J8C3
    Related
    FBpp0080130
    Conserved Domains (1) summary
    pfam01401
    Location:19 → 606
    Peptidase_M2; Angiotensin-converting enzyme
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