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npp-18 Nucleoporin SEH1 [ Caenorhabditis elegans ]

Gene ID: 176748, updated on 9-Dec-2024

Summary

Official Symbol
npp-18
Official Full Name
Nucleoporin SEH1
Primary source
WormBase:WBGene00003804
Locus tag
CELE_Y43F4B.4
See related
AllianceGenome:WB:WBGene00003804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable structural molecule activity. Predicted to be involved in cellular response to amino acid starvation and positive regulation of TORC1 signaling. Predicted to be located in lysosomal membrane and nuclear envelope. Predicted to be part of Seh1-associated complex and nuclear pore outer ring. Is expressed in intestine; nervous system; pharynx; and rectal gland cell. Orthologous to human SEH1L (SEH1 like nucleoporin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See npp-18 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (13296853..13298993)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase set-25 Neighboring gene NR LBD domain-containing protein Neighboring gene ncRNA Neighboring gene PGM_PMM_I domain-containing protein;Phosphoglucomutase-2 Neighboring gene ncRNA Neighboring gene Kinesin-like protein klp-19

Genomic regions, transcripts, and products

Genomic Sequence:
NC_003281.10

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Seh1-associated complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore outer ring IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Nucleoporin SEH1
NP_499740.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13296853..13298993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067339.6NP_499740.1  Nucleoporin SEH1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499740.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45933
    Conserved Domains (3) summary
    COG2319
    Location:11338
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2160
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:5250
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...