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    Minpp1 multiple inositol polyphosphate histidine phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 17330, updated on 9-Dec-2024

    Summary

    Official Symbol
    Minpp1provided by MGI
    Official Full Name
    multiple inositol polyphosphate histidine phosphatase 1provided by MGI
    Primary source
    MGI:MGI:1336159
    See related
    Ensembl:ENSMUSG00000024896 AllianceGenome:MGI:1336159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables inositol phosphate phosphatase activity. Is active in endoplasmic reticulum lumen and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 47.9), duodenum adult (RPKM 37.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Minpp1 in Genome Data Viewer
    Location:
    19 C1; 19 27.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32463169..32492770)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32485769..32515370)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 6 Neighboring gene predicted gene, 46659 Neighboring gene STARR-seq mESC enhancer starr_45949 Neighboring gene predicted gene, 36419 Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene STARR-seq mESC enhancer starr_45950 Neighboring gene predicted gene, 36492

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phytase activity  
    enables 4-phytase activity  
    enables acid phosphatase activity  
    enables bisphosphoglycerate 3-phosphatase activity  
    enables bisphosphoglycerate 3-phosphatase activity  
    enables inositol bisphosphate phosphatase activity  
    enables inositol bisphosphate phosphatase activity  
    enables inositol pentakisphosphate phosphatase activity  
    enables inositol pentakisphosphate phosphatase activity  
    enables inositol phosphate phosphatase activity  
    enables inositol phosphate phosphatase activity PubMed 
    enables inositol phosphate phosphatase activity PubMed 
    enables inositol trisphosphate phosphatase activity  
    enables inositol trisphosphate phosphatase activity  
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity  
    enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity  
    enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity  
    enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity  
    enables inositol-hexakisphosphate phosphatase activity  
    enables inositol-hexakisphosphate phosphatase activity  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen PubMed 
    is_active_in extracellular space  
    is_active_in extracellular space  
    is_active_in plasma membrane PubMed 

    General protein information

    Preferred Names
    multiple inositol polyphosphate phosphatase 1
    Names
    2,3-BPG phosphatase
    2,3-bisphosphoglycerate 3-phosphatase
    inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
    ins(1,3,4,5)P(4) 3-phosphatase
    NP_034929.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010799.2NP_034929.1  multiple inositol polyphosphate phosphatase 1 precursor

      See identical proteins and their annotated locations for NP_034929.1

      Status: VALIDATED

      Source sequence(s)
      AC115752, AK151486, AV297692
      Consensus CDS
      CCDS29751.1
      UniProtKB/Swiss-Prot
      Q3UA76, Q8VDR0, Q9JJD5, Q9Z2L6
      Related
      ENSMUSP00000025827.9, ENSMUST00000025827.10
      Conserved Domains (1) summary
      cd07061
      Location:82429
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      32463169..32492770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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